Classical trigeminal neuralgia is associated with gephyrin and sodium voltage-gated channel alpha subunit 8
Trigeminal neuralgia is highly debilitating, and its etiology is still undefined. The goal of this work was to define associations between well-characterized trigeminal neuralgia cases and common genetic variants in the population. two hundred and fifty-seven individuals diagnosed with classical tri...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-01-01
|
| Series: | Frontiers in Dental Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fdmed.2022.988094/full |
| _version_ | 1811175409562157056 |
|---|---|
| author | Alexandre R. Vieira Raymond F. Sekula Kathleen Deeley |
| author_facet | Alexandre R. Vieira Raymond F. Sekula Kathleen Deeley |
| author_sort | Alexandre R. Vieira |
| collection | DOAJ |
| description | Trigeminal neuralgia is highly debilitating, and its etiology is still undefined. The goal of this work was to define associations between well-characterized trigeminal neuralgia cases and common genetic variants in the population. two hundred and fifty-seven individuals diagnosed with classical trigeminal neuralgia were compared to 865 individuals without classical trigeminal neuralgia and with an assessment for lower or higher pain threshold based on the amount of anesthetic required for routine dental treatment. Genotypes of 24 variants marking genes in the VGSC (voltage-gated sodium channels) or GABA (gamma-aminobutyric acid) pathways were obtained using TaqMan chemistry end end-point analysis. Chi-square was used for all comparisons with an alpha of 0.002. An association between classical trigeminal neuralgia and individuals requiring less or more anesthetic for routine dental treatments showed associations with SCN8A rs1601012 and GPHN rs723432 (p = 0.0009 and p = 0.0002, respectively). In conclusion, classical trigeminal neuralgia is associated with SCN8A and GPHN and markers rs1601012 rs723432 may be useful to determine individual risks for the condition. |
| first_indexed | 2024-04-10T19:36:44Z |
| format | Article |
| id | doaj.art-8c57c27192fa487498a781d0ffdc8796 |
| institution | Directory Open Access Journal |
| issn | 2673-4915 |
| language | English |
| last_indexed | 2024-04-10T19:36:44Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Dental Medicine |
| spelling | doaj.art-8c57c27192fa487498a781d0ffdc87962023-01-30T05:22:05ZengFrontiers Media S.A.Frontiers in Dental Medicine2673-49152023-01-01310.3389/fdmed.2022.988094988094Classical trigeminal neuralgia is associated with gephyrin and sodium voltage-gated channel alpha subunit 8Alexandre R. VieiraRaymond F. SekulaKathleen DeeleyTrigeminal neuralgia is highly debilitating, and its etiology is still undefined. The goal of this work was to define associations between well-characterized trigeminal neuralgia cases and common genetic variants in the population. two hundred and fifty-seven individuals diagnosed with classical trigeminal neuralgia were compared to 865 individuals without classical trigeminal neuralgia and with an assessment for lower or higher pain threshold based on the amount of anesthetic required for routine dental treatment. Genotypes of 24 variants marking genes in the VGSC (voltage-gated sodium channels) or GABA (gamma-aminobutyric acid) pathways were obtained using TaqMan chemistry end end-point analysis. Chi-square was used for all comparisons with an alpha of 0.002. An association between classical trigeminal neuralgia and individuals requiring less or more anesthetic for routine dental treatments showed associations with SCN8A rs1601012 and GPHN rs723432 (p = 0.0009 and p = 0.0002, respectively). In conclusion, classical trigeminal neuralgia is associated with SCN8A and GPHN and markers rs1601012 rs723432 may be useful to determine individual risks for the condition.https://www.frontiersin.org/articles/10.3389/fdmed.2022.988094/fullpainorofacial paintrigeminal nervetrigeminal neuralgiaodontogenic painGABA |
| spellingShingle | Alexandre R. Vieira Raymond F. Sekula Kathleen Deeley Classical trigeminal neuralgia is associated with gephyrin and sodium voltage-gated channel alpha subunit 8 Frontiers in Dental Medicine pain orofacial pain trigeminal nerve trigeminal neuralgia odontogenic pain GABA |
| title | Classical trigeminal neuralgia is associated with gephyrin and sodium voltage-gated channel alpha subunit 8 |
| title_full | Classical trigeminal neuralgia is associated with gephyrin and sodium voltage-gated channel alpha subunit 8 |
| title_fullStr | Classical trigeminal neuralgia is associated with gephyrin and sodium voltage-gated channel alpha subunit 8 |
| title_full_unstemmed | Classical trigeminal neuralgia is associated with gephyrin and sodium voltage-gated channel alpha subunit 8 |
| title_short | Classical trigeminal neuralgia is associated with gephyrin and sodium voltage-gated channel alpha subunit 8 |
| title_sort | classical trigeminal neuralgia is associated with gephyrin and sodium voltage gated channel alpha subunit 8 |
| topic | pain orofacial pain trigeminal nerve trigeminal neuralgia odontogenic pain GABA |
| url | https://www.frontiersin.org/articles/10.3389/fdmed.2022.988094/full |
| work_keys_str_mv | AT alexandrervieira classicaltrigeminalneuralgiaisassociatedwithgephyrinandsodiumvoltagegatedchannelalphasubunit8 AT raymondfsekula classicaltrigeminalneuralgiaisassociatedwithgephyrinandsodiumvoltagegatedchannelalphasubunit8 AT kathleendeeley classicaltrigeminalneuralgiaisassociatedwithgephyrinandsodiumvoltagegatedchannelalphasubunit8 |