Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma
Abstract Background Oral squamous cell carcinoma causes a significant proportion of global cancer morbidity and mortality. The aim of this study is to investigate whether the exhaled breath test can be a new, non-invasive, and effective method for diagnosing oral squamous cell carcinoma. Methods A c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-07-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-022-02301-3 |
| _version_ | 1818234284189679616 |
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| author | Ik-Jae Kwon Tae-Young Jung Youjeong Son Bongju Kim Soung-Min Kim Jong-Ho Lee |
| author_facet | Ik-Jae Kwon Tae-Young Jung Youjeong Son Bongju Kim Soung-Min Kim Jong-Ho Lee |
| author_sort | Ik-Jae Kwon |
| collection | DOAJ |
| description | Abstract Background Oral squamous cell carcinoma causes a significant proportion of global cancer morbidity and mortality. The aim of this study is to investigate whether the exhaled breath test can be a new, non-invasive, and effective method for diagnosing oral squamous cell carcinoma. Methods A comparative analysis of exhaled breath between patients with oral squamous cell carcinoma (OSCC) and healthy controls (HC) was performed with the Twin Breasor II™, a simple gas chromatography system. Results Both hydrogen sulfide (H2S) and methyl mercaptan (Ch3SH) were significantly higher in the OSCC group than in the HC group. The total sulfur concentration was also higher in the OSCC group, but there was no significant difference in the ratio of Ch3SH to H2S between the two groups. Using logistic regression, we constructed a new variable with an area under the curve (AUC) of 0.740, 68.0% sensitivity, and 72.0% specificity. Conclusions Exhaled gas analysis via simple gas chromatography can potentially serve as an accessory non-invasive method for OSCC diagnosis. |
| first_indexed | 2024-12-12T11:35:38Z |
| format | Article |
| id | doaj.art-8c5b56c9f0394430b4301edc5f864633 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-12-12T11:35:38Z |
| publishDate | 2022-07-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-8c5b56c9f0394430b4301edc5f8646332022-12-22T00:25:40ZengBMCBMC Oral Health1472-68312022-07-012211810.1186/s12903-022-02301-3Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinomaIk-Jae Kwon0Tae-Young Jung1Youjeong Son2Bongju Kim3Soung-Min Kim4Jong-Ho Lee5Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National UniversityDepartment of Oral and Maxillofacial Surgery, Busan Paik Hospital, Inje UniversityDental Life Science Research Institute/Innovation Research & Support Center for Dental Science, Seoul National University Dental HospitalDental Life Science Research Institute/Innovation Research & Support Center for Dental Science, Seoul National University Dental HospitalDepartment of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National UniversityDepartment of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National UniversityAbstract Background Oral squamous cell carcinoma causes a significant proportion of global cancer morbidity and mortality. The aim of this study is to investigate whether the exhaled breath test can be a new, non-invasive, and effective method for diagnosing oral squamous cell carcinoma. Methods A comparative analysis of exhaled breath between patients with oral squamous cell carcinoma (OSCC) and healthy controls (HC) was performed with the Twin Breasor II™, a simple gas chromatography system. Results Both hydrogen sulfide (H2S) and methyl mercaptan (Ch3SH) were significantly higher in the OSCC group than in the HC group. The total sulfur concentration was also higher in the OSCC group, but there was no significant difference in the ratio of Ch3SH to H2S between the two groups. Using logistic regression, we constructed a new variable with an area under the curve (AUC) of 0.740, 68.0% sensitivity, and 72.0% specificity. Conclusions Exhaled gas analysis via simple gas chromatography can potentially serve as an accessory non-invasive method for OSCC diagnosis.https://doi.org/10.1186/s12903-022-02301-3Volatile sulfur compoundsExhaled breathOral squamous cell carcinomaHalitosisGas chromatography |
| spellingShingle | Ik-Jae Kwon Tae-Young Jung Youjeong Son Bongju Kim Soung-Min Kim Jong-Ho Lee Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma BMC Oral Health Volatile sulfur compounds Exhaled breath Oral squamous cell carcinoma Halitosis Gas chromatography |
| title | Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma |
| title_full | Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma |
| title_fullStr | Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma |
| title_full_unstemmed | Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma |
| title_short | Detection of volatile sulfur compounds (VSCs) in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma |
| title_sort | detection of volatile sulfur compounds vscs in exhaled breath as a potential diagnostic method for oral squamous cell carcinoma |
| topic | Volatile sulfur compounds Exhaled breath Oral squamous cell carcinoma Halitosis Gas chromatography |
| url | https://doi.org/10.1186/s12903-022-02301-3 |
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