Changes in lysophospholipids and liver status after weight loss: the RESMENA study
Abstract Background Obesity and comorbidities such as non-alcoholic fatty liver disease (NAFLD) are major public health burdens. Alterations in lipid metabolism are involved in hepatic diseases. The objective of this study was to assess the influence of weight loss on lysophospholipid (LP) metabolis...
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| Format: | Article |
| Language: | English |
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BMC
2018-07-01
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| Series: | Nutrition & Metabolism |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12986-018-0288-5 |
| _version_ | 1819014349859061760 |
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| author | Irene Cantero Itziar Abete Josep Maria del Bas Antoni Caimari Lluís Arola M. Angeles Zulet J. Alfredo Martinez |
| author_facet | Irene Cantero Itziar Abete Josep Maria del Bas Antoni Caimari Lluís Arola M. Angeles Zulet J. Alfredo Martinez |
| author_sort | Irene Cantero |
| collection | DOAJ |
| description | Abstract Background Obesity and comorbidities such as non-alcoholic fatty liver disease (NAFLD) are major public health burdens. Alterations in lipid metabolism are involved in hepatic diseases. The objective of this study was to assess the influence of weight loss on lysophospholipid (LP) metabolism and liver status in obese subjects as well as to provide new evidence regarding the interaction of LP metabolism as a key factor in the onset and management of obesity-related diseases such as liver damage. Methods Thirty-three subjects from the RESMENA (Reduction of Metabolic Syndrome in Navarra, NCT01087086) study were selected based on their Fatty Liver Index (FLI). Plasma lipid species (lysophosphatidilcholine: LPC, lysophosphatidilethanolamines: LPE and lysophosphatidylinositols: LPI specifically) were determined by LC-MS, while waist circumference (WC) and other non-invasive liver markers such as, FLI and BAAT scores as well as dietary records, anthropometrical measurements, body composition by DXA and other metabolic determinants were analyzed before and after a six-month hypocaloric nutritional intervention. Results Computed Z-scores of total LP (LPC, LPE, and LPI) were significantly decreased after 6-months of following a hypocaloric diet. Specifically, LPC14:0, LPC15:0, LPC16:1, LPC18:4, LPC20:4, showed clear relationships with weight loss. Changes in FLI score, WC and BAAT score revealed associations with general changes in LPC score. Interestingly the BAAT score was statistically associated with the LPC score after adjustment for weight loss. Conclusion The lipidomic LPC profile analysis revealed a generalized decrease in circulating lysophospholipids after weight loss. The involvement of particular LP in liver metabolism and obesity merit further attention, as some of these specific non-invasive liver markers were reduced independently of weight loss. Trial registration NCT01087086. Registered 15 March 2010, retrospectively registry. |
| first_indexed | 2024-12-21T02:14:26Z |
| format | Article |
| id | doaj.art-8c5c43e8930b4330b889cfa3e38ddc45 |
| institution | Directory Open Access Journal |
| issn | 1743-7075 |
| language | English |
| last_indexed | 2024-12-21T02:14:26Z |
| publishDate | 2018-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Nutrition & Metabolism |
| spelling | doaj.art-8c5c43e8930b4330b889cfa3e38ddc452022-12-21T19:19:17ZengBMCNutrition & Metabolism1743-70752018-07-0115111110.1186/s12986-018-0288-5Changes in lysophospholipids and liver status after weight loss: the RESMENA studyIrene Cantero0Itziar Abete1Josep Maria del Bas2Antoni Caimari3Lluís Arola4M. Angeles Zulet5J. Alfredo Martinez6Department of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of NavarraDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of NavarraTechnological Unit of Nutrition and Health, EURECAT-Technological Center of CataloniaTechnological Unit of Nutrition and Health, EURECAT-Technological Center of CataloniaTechnological Unit of Nutrition and Health, EURECAT-Technological Center of CataloniaDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of NavarraDepartment of Nutrition, Food Science and Physiology, Faculty of Pharmacy and Nutrition, University of NavarraAbstract Background Obesity and comorbidities such as non-alcoholic fatty liver disease (NAFLD) are major public health burdens. Alterations in lipid metabolism are involved in hepatic diseases. The objective of this study was to assess the influence of weight loss on lysophospholipid (LP) metabolism and liver status in obese subjects as well as to provide new evidence regarding the interaction of LP metabolism as a key factor in the onset and management of obesity-related diseases such as liver damage. Methods Thirty-three subjects from the RESMENA (Reduction of Metabolic Syndrome in Navarra, NCT01087086) study were selected based on their Fatty Liver Index (FLI). Plasma lipid species (lysophosphatidilcholine: LPC, lysophosphatidilethanolamines: LPE and lysophosphatidylinositols: LPI specifically) were determined by LC-MS, while waist circumference (WC) and other non-invasive liver markers such as, FLI and BAAT scores as well as dietary records, anthropometrical measurements, body composition by DXA and other metabolic determinants were analyzed before and after a six-month hypocaloric nutritional intervention. Results Computed Z-scores of total LP (LPC, LPE, and LPI) were significantly decreased after 6-months of following a hypocaloric diet. Specifically, LPC14:0, LPC15:0, LPC16:1, LPC18:4, LPC20:4, showed clear relationships with weight loss. Changes in FLI score, WC and BAAT score revealed associations with general changes in LPC score. Interestingly the BAAT score was statistically associated with the LPC score after adjustment for weight loss. Conclusion The lipidomic LPC profile analysis revealed a generalized decrease in circulating lysophospholipids after weight loss. The involvement of particular LP in liver metabolism and obesity merit further attention, as some of these specific non-invasive liver markers were reduced independently of weight loss. Trial registration NCT01087086. Registered 15 March 2010, retrospectively registry.http://link.springer.com/article/10.1186/s12986-018-0288-5LysophospholipidsObesityMetabolic syndromeLiverHypocaloric diet |
| spellingShingle | Irene Cantero Itziar Abete Josep Maria del Bas Antoni Caimari Lluís Arola M. Angeles Zulet J. Alfredo Martinez Changes in lysophospholipids and liver status after weight loss: the RESMENA study Nutrition & Metabolism Lysophospholipids Obesity Metabolic syndrome Liver Hypocaloric diet |
| title | Changes in lysophospholipids and liver status after weight loss: the RESMENA study |
| title_full | Changes in lysophospholipids and liver status after weight loss: the RESMENA study |
| title_fullStr | Changes in lysophospholipids and liver status after weight loss: the RESMENA study |
| title_full_unstemmed | Changes in lysophospholipids and liver status after weight loss: the RESMENA study |
| title_short | Changes in lysophospholipids and liver status after weight loss: the RESMENA study |
| title_sort | changes in lysophospholipids and liver status after weight loss the resmena study |
| topic | Lysophospholipids Obesity Metabolic syndrome Liver Hypocaloric diet |
| url | http://link.springer.com/article/10.1186/s12986-018-0288-5 |
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