MOLECULAR-GENETIC AND SERUM DISORDERS MARKERS OF FOLATE METABOLISM IN PATIENTS PROLIFERATIVE DISEASE AND BREAST CANCER
Aim: to study the relationship between homocysteine, cysteine and glutathione in blood serum and various single nucleotide polymorphisms (SNPs) of genes involved in folate metabolism in patients with proliferative breast disease and breast cancer. Material and methods. The study included 112 patient...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2017-06-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/519 |
| _version_ | 1797875873347534848 |
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| author | A. V. Markovsky N. N. Strambovskaya P. P. Tereshkov |
| author_facet | A. V. Markovsky N. N. Strambovskaya P. P. Tereshkov |
| author_sort | A. V. Markovsky |
| collection | DOAJ |
| description | Aim: to study the relationship between homocysteine, cysteine and glutathione in blood serum and various single nucleotide polymorphisms (SNPs) of genes involved in folate metabolism in patients with proliferative breast disease and breast cancer. Material and methods. The study included 112 patients with proliferative breast lesions and breast cancer in Transbaikalia. The control group consisted of 144 women having no breast cancer. Blood levels of homocysteine, cysteine and glutathione were evaluated by HPLC (high performance liquid chromatography). Genotyping was performed by polymerase chain reaction with the detection of amplification product in real-time. Results. Molecular-genetic testing revealed no association between breast disease and genetic polymorphisms of MTHFR(C677T), MTHFR(A1298C), MTR(A2756G), MTRR(A66G) in women with proliferative breast lesions and breast cancer, however, in contrast to the control group, the concentrations of homocysteine and glutathione were increased. |
| first_indexed | 2024-04-10T01:53:27Z |
| format | Article |
| id | doaj.art-8c5dc17b993b44b6959d128b47e8a794 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2024-04-10T01:53:27Z |
| publishDate | 2017-06-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-8c5dc17b993b44b6959d128b47e8a7942023-03-13T09:05:50ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682017-06-01162505510.21294/1814-4861-2017-16-2-50-55434MOLECULAR-GENETIC AND SERUM DISORDERS MARKERS OF FOLATE METABOLISM IN PATIENTS PROLIFERATIVE DISEASE AND BREAST CANCERA. V. Markovsky0N. N. Strambovskaya1P. P. Tereshkov2ФГБОУ ВО «Читинская государственная медицинская академия»ФГБОУ ВО «Читинская государственная медицинская академия»ФГБОУ ВО «Читинская государственная медицинская академия»Aim: to study the relationship between homocysteine, cysteine and glutathione in blood serum and various single nucleotide polymorphisms (SNPs) of genes involved in folate metabolism in patients with proliferative breast disease and breast cancer. Material and methods. The study included 112 patients with proliferative breast lesions and breast cancer in Transbaikalia. The control group consisted of 144 women having no breast cancer. Blood levels of homocysteine, cysteine and glutathione were evaluated by HPLC (high performance liquid chromatography). Genotyping was performed by polymerase chain reaction with the detection of amplification product in real-time. Results. Molecular-genetic testing revealed no association between breast disease and genetic polymorphisms of MTHFR(C677T), MTHFR(A1298C), MTR(A2756G), MTRR(A66G) in women with proliferative breast lesions and breast cancer, however, in contrast to the control group, the concentrations of homocysteine and glutathione were increased.https://www.siboncoj.ru/jour/article/view/519пролиферативные заболевания и рак молочной железыгенетический полиморфизмпредрасположенностьконцентрация тиолов |
| spellingShingle | A. V. Markovsky N. N. Strambovskaya P. P. Tereshkov MOLECULAR-GENETIC AND SERUM DISORDERS MARKERS OF FOLATE METABOLISM IN PATIENTS PROLIFERATIVE DISEASE AND BREAST CANCER Сибирский онкологический журнал пролиферативные заболевания и рак молочной железы генетический полиморфизм предрасположенность концентрация тиолов |
| title | MOLECULAR-GENETIC AND SERUM DISORDERS MARKERS OF FOLATE METABOLISM IN PATIENTS PROLIFERATIVE DISEASE AND BREAST CANCER |
| title_full | MOLECULAR-GENETIC AND SERUM DISORDERS MARKERS OF FOLATE METABOLISM IN PATIENTS PROLIFERATIVE DISEASE AND BREAST CANCER |
| title_fullStr | MOLECULAR-GENETIC AND SERUM DISORDERS MARKERS OF FOLATE METABOLISM IN PATIENTS PROLIFERATIVE DISEASE AND BREAST CANCER |
| title_full_unstemmed | MOLECULAR-GENETIC AND SERUM DISORDERS MARKERS OF FOLATE METABOLISM IN PATIENTS PROLIFERATIVE DISEASE AND BREAST CANCER |
| title_short | MOLECULAR-GENETIC AND SERUM DISORDERS MARKERS OF FOLATE METABOLISM IN PATIENTS PROLIFERATIVE DISEASE AND BREAST CANCER |
| title_sort | molecular genetic and serum disorders markers of folate metabolism in patients proliferative disease and breast cancer |
| topic | пролиферативные заболевания и рак молочной железы генетический полиморфизм предрасположенность концентрация тиолов |
| url | https://www.siboncoj.ru/jour/article/view/519 |
| work_keys_str_mv | AT avmarkovsky moleculargeneticandserumdisordersmarkersoffolatemetabolisminpatientsproliferativediseaseandbreastcancer AT nnstrambovskaya moleculargeneticandserumdisordersmarkersoffolatemetabolisminpatientsproliferativediseaseandbreastcancer AT pptereshkov moleculargeneticandserumdisordersmarkersoffolatemetabolisminpatientsproliferativediseaseandbreastcancer |