Flow chemistry in the multi-step synthesis of natural products
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the large environmental footprint. In the past two decades, performing chemical transformations in conti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2022-08-01
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| Series: | Green Synthesis and Catalysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666554922000795 |
| _version_ | 1811183357095051264 |
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| author | Li Wan Gaopan Kong Minjie Liu Meifen Jiang Dang Cheng Fener Chen |
| author_facet | Li Wan Gaopan Kong Minjie Liu Meifen Jiang Dang Cheng Fener Chen |
| author_sort | Li Wan |
| collection | DOAJ |
| description | The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the large environmental footprint. In the past two decades, performing chemical transformations in continuous flow using various types of microreactors and in-line auxiliary technologies have been demonstrated effectively in respects of enhanced reaction yield and selectivity, excellent reproducibility and easy scale-up, safe proceeding hazardous reaction. And the rapid synthesis of natural products, which has been enabled in continuous flow based upon the significant improvement of overall yield within a short residence time via processing intensification and systematic automation, is essential to furnish sufficient quantity for the bioactivity investigation of structural diversity modification, structure-activity relationship during drug discovery and the increasing consumption of medical treatment. In this review, the multi-step continuous flow synthesis of natural products is highlighted to provide a comprehensive recognization on the intrinsic merits of flow chemistry for organic chemists to purposefully develop the flow synthetic approaches of natural products in the future. |
| first_indexed | 2024-04-11T09:46:33Z |
| format | Article |
| id | doaj.art-8c5dceccaf154f8d8328c8f79016f19e |
| institution | Directory Open Access Journal |
| issn | 2666-5549 |
| language | English |
| last_indexed | 2024-04-11T09:46:33Z |
| publishDate | 2022-08-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Green Synthesis and Catalysis |
| spelling | doaj.art-8c5dceccaf154f8d8328c8f79016f19e2022-12-22T04:30:57ZengKeAi Communications Co. Ltd.Green Synthesis and Catalysis2666-55492022-08-0133243258Flow chemistry in the multi-step synthesis of natural productsLi Wan0Gaopan Kong1Minjie Liu2Meifen Jiang3Dang Cheng4Fener Chen5Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, ChinaEnvironmental and Industrial Fluid Dynamics Group, Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Rd, Cambridge CB3 0WA, United KingdomEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, ChinaEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, ChinaEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, ChinaEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China; Shanghai Engineering Center of Industrial Asymmetric Catalysis for Chiral Drugs, Shanghai 200433, China; Corresponding author. Engineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the large environmental footprint. In the past two decades, performing chemical transformations in continuous flow using various types of microreactors and in-line auxiliary technologies have been demonstrated effectively in respects of enhanced reaction yield and selectivity, excellent reproducibility and easy scale-up, safe proceeding hazardous reaction. And the rapid synthesis of natural products, which has been enabled in continuous flow based upon the significant improvement of overall yield within a short residence time via processing intensification and systematic automation, is essential to furnish sufficient quantity for the bioactivity investigation of structural diversity modification, structure-activity relationship during drug discovery and the increasing consumption of medical treatment. In this review, the multi-step continuous flow synthesis of natural products is highlighted to provide a comprehensive recognization on the intrinsic merits of flow chemistry for organic chemists to purposefully develop the flow synthetic approaches of natural products in the future.http://www.sciencedirect.com/science/article/pii/S2666554922000795Flow chemistryMulti-step synthesisNatural productsMicroreactorIn-line separation |
| spellingShingle | Li Wan Gaopan Kong Minjie Liu Meifen Jiang Dang Cheng Fener Chen Flow chemistry in the multi-step synthesis of natural products Green Synthesis and Catalysis Flow chemistry Multi-step synthesis Natural products Microreactor In-line separation |
| title | Flow chemistry in the multi-step synthesis of natural products |
| title_full | Flow chemistry in the multi-step synthesis of natural products |
| title_fullStr | Flow chemistry in the multi-step synthesis of natural products |
| title_full_unstemmed | Flow chemistry in the multi-step synthesis of natural products |
| title_short | Flow chemistry in the multi-step synthesis of natural products |
| title_sort | flow chemistry in the multi step synthesis of natural products |
| topic | Flow chemistry Multi-step synthesis Natural products Microreactor In-line separation |
| url | http://www.sciencedirect.com/science/article/pii/S2666554922000795 |
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