EXPRESSION PROFILE OF MICRORNAS IN SQUAMOUS CELL HEAD AND NECK CARCINOMA
Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with long asymptomatic course. New molecular prognostic markers are urgently needed to identify patients at high risk for developing lymph node metastasis. MicroRNAs (miRNAs) are a recently discovered class of small non-cod...
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/199 |
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| author | Yu. A. Veryaskina G. V. Kakurina E. S. Zhuravlev S. E. Titov I. V. Kondakova O. V. Cheremisina D. A. Shishkin I. F. Zhimulev E. L. Choynzonov N. N. Kolesnikov |
| author_facet | Yu. A. Veryaskina G. V. Kakurina E. S. Zhuravlev S. E. Titov I. V. Kondakova O. V. Cheremisina D. A. Shishkin I. F. Zhimulev E. L. Choynzonov N. N. Kolesnikov |
| author_sort | Yu. A. Veryaskina |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with long asymptomatic course. New molecular prognostic markers are urgently needed to identify patients at high risk for developing lymph node metastasis. MicroRNAs (miRNAs) are a recently discovered class of small non-coding RNAs. Based on literature and our data, we have chosen 12 miRNAs (miRNA-21, -221, -222, -155, -205, -20a, -125b, -146b, -181b, -200a, -126, -451), involved in HNSCC carcinogenesis. Using real-time quantitative polymerase chain reaction analysis, we have shown a change in the expression miRNA in tumor tissue compared to unmodified tissue. Significant upregulation of five miRNAs: miRNA-21, -155, -181b, -126, -451 (p<0.05) has been shown in tumors. MiRNA-126 has been found to be highly expressed in metastasis tissue (p<0.05), and can be an important factor in understanding the processes of metastasis and development of a new prognostic marker. |
| first_indexed | 2024-04-10T01:54:24Z |
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| id | doaj.art-8c5fc23e3ccb4296adf72ff1a3554539 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2025-03-14T10:09:48Z |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-8c5fc23e3ccb4296adf72ff1a35545392025-03-02T11:16:05ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-01063338199EXPRESSION PROFILE OF MICRORNAS IN SQUAMOUS CELL HEAD AND NECK CARCINOMAYu. A. Veryaskina0G. V. Kakurina1E. S. Zhuravlev2S. E. Titov3I. V. Kondakova4O. V. Cheremisina5D. A. Shishkin6I. F. Zhimulev7E. L. Choynzonov8N. N. Kolesnikov9Institute of Molecular and Cellular Biology SB RAS, NovosibirskTomsk Cancer Research InstituteInstitute of Molecular and Cellular Biology SB RAS, NovosibirskInstitute of Molecular and Cellular Biology SB RAS, Novosibirsk; Vector-Best Ltd, NovosibirskTomsk Cancer Research InstituteTomsk Cancer Research InstituteTomsk Cancer Research InstituteInstitute of Molecular and Cellular Biology SB RAS, NovosibirskTomsk Cancer Research Institute; Siberian State Medical University, TomskInstitute of Molecular and Cellular Biology SB RAS, NovosibirskHead and neck squamous cell carcinoma (HNSCC) is a highly aggressive disease with long asymptomatic course. New molecular prognostic markers are urgently needed to identify patients at high risk for developing lymph node metastasis. MicroRNAs (miRNAs) are a recently discovered class of small non-coding RNAs. Based on literature and our data, we have chosen 12 miRNAs (miRNA-21, -221, -222, -155, -205, -20a, -125b, -146b, -181b, -200a, -126, -451), involved in HNSCC carcinogenesis. Using real-time quantitative polymerase chain reaction analysis, we have shown a change in the expression miRNA in tumor tissue compared to unmodified tissue. Significant upregulation of five miRNAs: miRNA-21, -155, -181b, -126, -451 (p<0.05) has been shown in tumors. MiRNA-126 has been found to be highly expressed in metastasis tissue (p<0.05), and can be an important factor in understanding the processes of metastasis and development of a new prognostic marker.https://www.siboncoj.ru/jour/article/view/199head and neck tumors, mirna, metastasis |
| spellingShingle | Yu. A. Veryaskina G. V. Kakurina E. S. Zhuravlev S. E. Titov I. V. Kondakova O. V. Cheremisina D. A. Shishkin I. F. Zhimulev E. L. Choynzonov N. N. Kolesnikov EXPRESSION PROFILE OF MICRORNAS IN SQUAMOUS CELL HEAD AND NECK CARCINOMA Сибирский онкологический журнал head and neck tumors, mirna, metastasis |
| title | EXPRESSION PROFILE OF MICRORNAS IN SQUAMOUS CELL HEAD AND NECK CARCINOMA |
| title_full | EXPRESSION PROFILE OF MICRORNAS IN SQUAMOUS CELL HEAD AND NECK CARCINOMA |
| title_fullStr | EXPRESSION PROFILE OF MICRORNAS IN SQUAMOUS CELL HEAD AND NECK CARCINOMA |
| title_full_unstemmed | EXPRESSION PROFILE OF MICRORNAS IN SQUAMOUS CELL HEAD AND NECK CARCINOMA |
| title_short | EXPRESSION PROFILE OF MICRORNAS IN SQUAMOUS CELL HEAD AND NECK CARCINOMA |
| title_sort | expression profile of micrornas in squamous cell head and neck carcinoma |
| topic | head and neck tumors, mirna, metastasis |
| url | https://www.siboncoj.ru/jour/article/view/199 |
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