Racial Disparities in Surgical Management For Early‐Stage Laryngeal Squamous Cell Carcinoma and Recurrent Dysplasia
Abstract Objective The aim of this study is to evaluate the association between race and the treatment of laryngeal dysplasia and early‐stage laryngeal squamous cell carcinoma (LSCC). Study design Retrospective Cohort Study. Setting Large multispecialty academic medical center. Methods Patients were...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | OTO Open |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/oto2.119 |
| _version_ | 1797223041844903936 |
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| author | Thomas F. Cyberski Alexander Z. Wang Brandon J. Baird |
| author_facet | Thomas F. Cyberski Alexander Z. Wang Brandon J. Baird |
| author_sort | Thomas F. Cyberski |
| collection | DOAJ |
| description | Abstract Objective The aim of this study is to evaluate the association between race and the treatment of laryngeal dysplasia and early‐stage laryngeal squamous cell carcinoma (LSCC). Study design Retrospective Cohort Study. Setting Large multispecialty academic medical center. Methods Patients were treated for laryngeal dysplasia or LSCC between September 2019 and September 2022. A retrospective chart review was conducted to collect demographic and clinical information. Two‐sample t tests, chi‐square tests, and linear regression models were used to compare characteristics (α = 0.05). Analyses were performed in STATA 17. Results Sixty‐five patients were identified that underwent potassium titanyl phosphate (KTP) transoral laser microsurgery for management of early‐stage LSCC (n = 29) or dysplasia (n = 36). The cohort consisted of 23 Black and 42 White patients. No significant difference was found in age, alcohol or tobacco use, rate of adjuvant radiotherapy, stage of disease, nor insurance status between the 2 groups. White patients underwent more procedures to address initial disease and subsequent recurrent dysplasia on average than Black patients (2.52 vs 1.52, P = .02). This remained true after adjusting for demographic and clinical characteristics and insurance status in a linear regression model. While Black patients were more likely to be lost to follow‐up than White patients (30.4% vs 9.5%, P = .03), the average number of procedures between the groups still differed significantly (2.63 vs 1.56, P = .04) when controlling for those lost to follow‐up. Conclusion The findings presented here highlight potential inequities that exist for racial minorities at early stages of treatment and in addressing premalignant conditions, which may contribute to the known downstream disparities in laryngeal cancer outcomes. |
| first_indexed | 2024-04-24T13:30:55Z |
| format | Article |
| id | doaj.art-8c6024315549402c8748e3486d14d428 |
| institution | Directory Open Access Journal |
| issn | 2473-974X |
| language | English |
| last_indexed | 2024-04-24T13:30:55Z |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | OTO Open |
| spelling | doaj.art-8c6024315549402c8748e3486d14d4282024-04-04T09:30:28ZengWileyOTO Open2473-974X2024-01-0181n/an/a10.1002/oto2.119Racial Disparities in Surgical Management For Early‐Stage Laryngeal Squamous Cell Carcinoma and Recurrent DysplasiaThomas F. Cyberski0Alexander Z. Wang1Brandon J. Baird2Pritzker School of Medicine The University of Chicago Chicago Illinois USAPritzker School of Medicine The University of Chicago Chicago Illinois USASection of Otolaryngology–Head and Neck Surgery, Department of Surgery The University of Chicago Medicine Chicago Illinois USAAbstract Objective The aim of this study is to evaluate the association between race and the treatment of laryngeal dysplasia and early‐stage laryngeal squamous cell carcinoma (LSCC). Study design Retrospective Cohort Study. Setting Large multispecialty academic medical center. Methods Patients were treated for laryngeal dysplasia or LSCC between September 2019 and September 2022. A retrospective chart review was conducted to collect demographic and clinical information. Two‐sample t tests, chi‐square tests, and linear regression models were used to compare characteristics (α = 0.05). Analyses were performed in STATA 17. Results Sixty‐five patients were identified that underwent potassium titanyl phosphate (KTP) transoral laser microsurgery for management of early‐stage LSCC (n = 29) or dysplasia (n = 36). The cohort consisted of 23 Black and 42 White patients. No significant difference was found in age, alcohol or tobacco use, rate of adjuvant radiotherapy, stage of disease, nor insurance status between the 2 groups. White patients underwent more procedures to address initial disease and subsequent recurrent dysplasia on average than Black patients (2.52 vs 1.52, P = .02). This remained true after adjusting for demographic and clinical characteristics and insurance status in a linear regression model. While Black patients were more likely to be lost to follow‐up than White patients (30.4% vs 9.5%, P = .03), the average number of procedures between the groups still differed significantly (2.63 vs 1.56, P = .04) when controlling for those lost to follow‐up. Conclusion The findings presented here highlight potential inequities that exist for racial minorities at early stages of treatment and in addressing premalignant conditions, which may contribute to the known downstream disparities in laryngeal cancer outcomes.https://doi.org/10.1002/oto2.119cancerdisparitiesdysplasialarynxrace |
| spellingShingle | Thomas F. Cyberski Alexander Z. Wang Brandon J. Baird Racial Disparities in Surgical Management For Early‐Stage Laryngeal Squamous Cell Carcinoma and Recurrent Dysplasia OTO Open cancer disparities dysplasia larynx race |
| title | Racial Disparities in Surgical Management For Early‐Stage Laryngeal Squamous Cell Carcinoma and Recurrent Dysplasia |
| title_full | Racial Disparities in Surgical Management For Early‐Stage Laryngeal Squamous Cell Carcinoma and Recurrent Dysplasia |
| title_fullStr | Racial Disparities in Surgical Management For Early‐Stage Laryngeal Squamous Cell Carcinoma and Recurrent Dysplasia |
| title_full_unstemmed | Racial Disparities in Surgical Management For Early‐Stage Laryngeal Squamous Cell Carcinoma and Recurrent Dysplasia |
| title_short | Racial Disparities in Surgical Management For Early‐Stage Laryngeal Squamous Cell Carcinoma and Recurrent Dysplasia |
| title_sort | racial disparities in surgical management for early stage laryngeal squamous cell carcinoma and recurrent dysplasia |
| topic | cancer disparities dysplasia larynx race |
| url | https://doi.org/10.1002/oto2.119 |
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