Detection of a G-Quadruplex as a Regulatory Element in <i>Thymidylate synthase</i> for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins

Detection of a G-Quadruplex as a Regulatory Element in <i>Thymidylate synthase</i> for Gene Silencing Using Polypurine Reverse Hoogsteen Hairpins

Thymidylate synthase (TYMS) enzyme is an anti-cancer target given its role in DNA biosynthesis. TYMS inhibitors (e.g., 5-Fluorouracil) can lead to drug resistance through an autoregulatory mechanism of TYMS that causes its overexpression. Since G-quadruplexes (G4) can modulate gene expression, we se...

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Bibliographic Details
Main Authors: Eva Aubets, Alex J. Félix, Miguel Garavís, Laura Reyes, Anna Aviñó, Ramón Eritja, Carlos J. Ciudad, Véronique Noé
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplex
PPRH
thymidylate synthase
anti-tumor therapy
5-fluorouracil
gene silencing
Online Access:https://www.mdpi.com/1422-0067/21/14/5028

Internet

https://www.mdpi.com/1422-0067/21/14/5028

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