Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy
Abstract Polychlorinated biphenyls (PCBs) are human carcinogens, based on sufficient evidence for melanoma and limited evidence for non-Hodgkin lymphoma and breast cancer. Few data are available for liver cancer, although PCBs cause it in rats and determined liver damage in poisoned people. We inves...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-02-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-82657-8 |
| _version_ | 1818692379856601088 |
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| author | Francesco Donato Marco Moneda Nazario Portolani Angelo Rossini Sarah Molfino Silvia Ministrini Giovanni Battista Contessi Silvia Pesenti Giuseppe De Palma Alice Gaia Elena Zanardini Claudio Vito Sileo Michele Magoni |
| author_facet | Francesco Donato Marco Moneda Nazario Portolani Angelo Rossini Sarah Molfino Silvia Ministrini Giovanni Battista Contessi Silvia Pesenti Giuseppe De Palma Alice Gaia Elena Zanardini Claudio Vito Sileo Michele Magoni |
| author_sort | Francesco Donato |
| collection | DOAJ |
| description | Abstract Polychlorinated biphenyls (PCBs) are human carcinogens, based on sufficient evidence for melanoma and limited evidence for non-Hodgkin lymphoma and breast cancer. Few data are available for liver cancer, although PCBs cause it in rats and determined liver damage in poisoned people. We investigated the association between PCB serum levels and hepatocellular carcinoma (HCC) with a case–control study in a PCB-polluted area in North Italy. We enrolled prospectively 102 HCC incident cases and 102 age and gender-matched hospital controls. Serum concentrations of 33 PCB congeners were determined by a gas chromatograph coupled to mass spectrometry. Of 102 HCC cases, 62 who had lost < 3 kg of body weight in past 3 years were included in the analysis (67.7% males, mean age 68 years). The odds ratio (OR) for HCC for 3rd compared to 1st tertile of PCB distribution was 1.76 (95% confidence interval 0.62–5.03) for total PCB, adjusting for socio-demographic variables and risk factors for HCC by logistic regression. For most PCB congeners, ORs > 1.5 or 2 were found, although the 95% CIs included the null value for almost all of them. This preliminary study suggests that PCBs might play a role in HCC development. |
| first_indexed | 2024-12-17T12:56:52Z |
| format | Article |
| id | doaj.art-8c61dfe805924fbd95fa80ee94bbfe21 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-17T12:56:52Z |
| publishDate | 2021-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8c61dfe805924fbd95fa80ee94bbfe212022-12-21T21:47:28ZengNature PortfolioScientific Reports2045-23222021-02-011111910.1038/s41598-021-82657-8Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in ItalyFrancesco Donato0Marco Moneda1Nazario Portolani2Angelo Rossini3Sarah Molfino4Silvia Ministrini5Giovanni Battista Contessi6Silvia Pesenti7Giuseppe De Palma8Alice Gaia9Elena Zanardini10Claudio Vito Sileo11Michele Magoni12Unit of Hygiene, Epidemiology and Public Health, University of BresciaPost-Graduate School of Public Health, University of BresciaDepartment of Clinical and Experimental Sciences, Surgical Clinic, University of BresciaHepatology Unit, Spedali Civili General Hospital, ASST (Territorial Socio-Sanitary Agency) Spedali Civili Di BresciaDepartment of Clinical and Experimental Sciences, Surgical Clinic, University of BresciaDepartment of Clinical and Experimental Sciences, Surgical Clinic, University of BresciaHepatology Unit, Spedali Civili General Hospital, ASST (Territorial Socio-Sanitary Agency) Spedali Civili Di BresciaHepatology Unit, Spedali Civili General Hospital, ASST (Territorial Socio-Sanitary Agency) Spedali Civili Di BresciaUnit of Occupational Health and Industrial Hygiene, University of BresciaUnit of Occupational Health, Hygiene, Toxicology and Prevention, ASST (Territorial Socio-Sanitary Agency) Spedali Civili Di BresciaPost-Graduate School of Public Health, University of BresciaATS Brescia (Brescia Health Protection Agency)ATS Brescia (Brescia Health Protection Agency)Abstract Polychlorinated biphenyls (PCBs) are human carcinogens, based on sufficient evidence for melanoma and limited evidence for non-Hodgkin lymphoma and breast cancer. Few data are available for liver cancer, although PCBs cause it in rats and determined liver damage in poisoned people. We investigated the association between PCB serum levels and hepatocellular carcinoma (HCC) with a case–control study in a PCB-polluted area in North Italy. We enrolled prospectively 102 HCC incident cases and 102 age and gender-matched hospital controls. Serum concentrations of 33 PCB congeners were determined by a gas chromatograph coupled to mass spectrometry. Of 102 HCC cases, 62 who had lost < 3 kg of body weight in past 3 years were included in the analysis (67.7% males, mean age 68 years). The odds ratio (OR) for HCC for 3rd compared to 1st tertile of PCB distribution was 1.76 (95% confidence interval 0.62–5.03) for total PCB, adjusting for socio-demographic variables and risk factors for HCC by logistic regression. For most PCB congeners, ORs > 1.5 or 2 were found, although the 95% CIs included the null value for almost all of them. This preliminary study suggests that PCBs might play a role in HCC development.https://doi.org/10.1038/s41598-021-82657-8 |
| spellingShingle | Francesco Donato Marco Moneda Nazario Portolani Angelo Rossini Sarah Molfino Silvia Ministrini Giovanni Battista Contessi Silvia Pesenti Giuseppe De Palma Alice Gaia Elena Zanardini Claudio Vito Sileo Michele Magoni Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy Scientific Reports |
| title | Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy |
| title_full | Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy |
| title_fullStr | Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy |
| title_full_unstemmed | Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy |
| title_short | Polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in Italy |
| title_sort | polychlorinated biphenyls and risk of hepatocellular carcinoma in the population living in a highly polluted area in italy |
| url | https://doi.org/10.1038/s41598-021-82657-8 |
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