Tumor Copy Number Alteration Burden as a Predictor for Resistance to Immune Checkpoint Blockade across Different Cancer Types

Tumor Copy Number Alteration Burden as a Predictor for Resistance to Immune Checkpoint Blockade across Different Cancer Types

Immune checkpoint blockade (ICB) benefits only a subset of advanced cancer patients, and predictive biomarkers for immunotherapy response are needed. Recently, copy number alteration (CNA) burden has been proposed to predict ICB resistance. We assessed this finding using the publicly accessible data...

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Bibliographic Details
Main Authors: Karama Asleh, Rodney J. Ouellette
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Cancers
Subjects:
copy number alteration burden
tumor mutational burden
immune checkpoint blockade
next-generation sequencing
MSK-IMPACT assay
predictive biomarkers
Online Access:https://www.mdpi.com/2072-6694/16/4/732

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