Inherited Sensory and Autonomic Neuropathy in a Border Collie, Interest of Oclacitinib for the Control of Self-Mutilation
Sensory and autonomic neuropathy was diagnosed in a five-month-old Border Collie puppy, who presented with progressive self-mutilation, proprioceptive ataxia and urinary incontinence. In the Border Collie, sensory neuropathy is different from what is observed in acral mutilation syndrome, as the gen...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/9/3/127 |
| _version_ | 1797441092739661824 |
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| author | Caroline Leonard Iris Van Soens Jacques Fontaine |
| author_facet | Caroline Leonard Iris Van Soens Jacques Fontaine |
| author_sort | Caroline Leonard |
| collection | DOAJ |
| description | Sensory and autonomic neuropathy was diagnosed in a five-month-old Border Collie puppy, who presented with progressive self-mutilation, proprioceptive ataxia and urinary incontinence. In the Border Collie, sensory neuropathy is different from what is observed in acral mutilation syndrome, as the genetic mutation is linked to an inversion disrupting the <i>FAM134B</i> gene. Diagnosis was based on history, clinical signs and genetic testing. The prognosis of sensory neuropathies is poor and no curative treatment is available. In the present case, oclacitinib was started for symptomatic treatment of the self-mutilation. A good control of the self-mutilation was quickly observed with an improvement in quality of life for five months. Unfortunately, progression of neurological signs with severe proprioceptive deficits, ataxia, muscular atrophy and urinary/fecal incontinence was observed. Five months after diagnosis, the owner elected for euthanasia. |
| first_indexed | 2024-03-09T12:18:04Z |
| format | Article |
| id | doaj.art-8c62cba174ef441cadf487dbe289d7cf |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-09T12:18:04Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-8c62cba174ef441cadf487dbe289d7cf2023-11-30T22:44:32ZengMDPI AGVeterinary Sciences2306-73812022-03-019312710.3390/vetsci9030127Inherited Sensory and Autonomic Neuropathy in a Border Collie, Interest of Oclacitinib for the Control of Self-MutilationCaroline Leonard0Iris Van Soens1Jacques Fontaine2Department for Clinical Sciences, Faculté de Médecine Vétérinaire, University of Liege, Quartier Vallée 2, Avenue de Cureghem 3, Sart-Tilman, 4000 Liege, BelgiumDepartment for Clinical Sciences, Faculté de Médecine Vétérinaire, University of Liege, Quartier Vallée 2, Avenue de Cureghem 3, Sart-Tilman, 4000 Liege, BelgiumDepartment for Clinical Sciences, Faculté de Médecine Vétérinaire, University of Liege, Quartier Vallée 2, Avenue de Cureghem 3, Sart-Tilman, 4000 Liege, BelgiumSensory and autonomic neuropathy was diagnosed in a five-month-old Border Collie puppy, who presented with progressive self-mutilation, proprioceptive ataxia and urinary incontinence. In the Border Collie, sensory neuropathy is different from what is observed in acral mutilation syndrome, as the genetic mutation is linked to an inversion disrupting the <i>FAM134B</i> gene. Diagnosis was based on history, clinical signs and genetic testing. The prognosis of sensory neuropathies is poor and no curative treatment is available. In the present case, oclacitinib was started for symptomatic treatment of the self-mutilation. A good control of the self-mutilation was quickly observed with an improvement in quality of life for five months. Unfortunately, progression of neurological signs with severe proprioceptive deficits, ataxia, muscular atrophy and urinary/fecal incontinence was observed. Five months after diagnosis, the owner elected for euthanasia.https://www.mdpi.com/2306-7381/9/3/127canine<i>FAM134B</i> geneneuropathiesgenetictreatment |
| spellingShingle | Caroline Leonard Iris Van Soens Jacques Fontaine Inherited Sensory and Autonomic Neuropathy in a Border Collie, Interest of Oclacitinib for the Control of Self-Mutilation Veterinary Sciences canine <i>FAM134B</i> gene neuropathies genetic treatment |
| title | Inherited Sensory and Autonomic Neuropathy in a Border Collie, Interest of Oclacitinib for the Control of Self-Mutilation |
| title_full | Inherited Sensory and Autonomic Neuropathy in a Border Collie, Interest of Oclacitinib for the Control of Self-Mutilation |
| title_fullStr | Inherited Sensory and Autonomic Neuropathy in a Border Collie, Interest of Oclacitinib for the Control of Self-Mutilation |
| title_full_unstemmed | Inherited Sensory and Autonomic Neuropathy in a Border Collie, Interest of Oclacitinib for the Control of Self-Mutilation |
| title_short | Inherited Sensory and Autonomic Neuropathy in a Border Collie, Interest of Oclacitinib for the Control of Self-Mutilation |
| title_sort | inherited sensory and autonomic neuropathy in a border collie interest of oclacitinib for the control of self mutilation |
| topic | canine <i>FAM134B</i> gene neuropathies genetic treatment |
| url | https://www.mdpi.com/2306-7381/9/3/127 |
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