Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer Effects
Colorectal cancer is the third most common cancer in the world. Due to the side effects of common treatments such as chemotherapy and radiotherapy, the use of herbal medicines has received much attention. Artemether (ARM) is an herbal medicine derived from artemisinin, which has many anti-tumor prop...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/11/2713 |
| _version_ | 1827647159256743936 |
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| author | Zeynab Pirali-Hamedani Ardeshir Abbasi Zuhair Mohammad Hassan |
| author_facet | Zeynab Pirali-Hamedani Ardeshir Abbasi Zuhair Mohammad Hassan |
| author_sort | Zeynab Pirali-Hamedani |
| collection | DOAJ |
| description | Colorectal cancer is the third most common cancer in the world. Due to the side effects of common treatments such as chemotherapy and radiotherapy, the use of herbal medicines has received much attention. Artemether (ARM) is an herbal medicine derived from artemisinin, which has many anti-tumor properties. However, factors such as low solubility and short half-life have limited the use of artemether in clinical practice. In this study, we aimed to reduce these limitations by encapsulating artemether in human serum albumin (HSA). The hydrodynamic diameter and the zeta potential value of ARM-ALB nanoparticles (NPs) were 171.3 ± 5.88 nm and −19.1 ± 0.82 mV, respectively. Comparison of the effect of free and encapsulated artemether on CT 26 cell line showed that the use of artemether in capsulated form can reduce the effective concentration of the drug. Additionally, in vivo studies have also shown that albumin–artemether nanoparticles can control tumor growth by increasing the production of cytokine IFN-γ and decreasing the production of IL4. Therefore, ARM-ALB nanoparticles have greater anti-tumor effects than free artemether. |
| first_indexed | 2024-03-09T19:15:17Z |
| format | Article |
| id | doaj.art-8c646ee2528644d88c565ca4a0461fcf |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T19:15:17Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-8c646ee2528644d88c565ca4a0461fcf2023-11-24T03:49:27ZengMDPI AGBiomedicines2227-90592022-10-011011271310.3390/biomedicines10112713Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer EffectsZeynab Pirali-Hamedani0Ardeshir Abbasi1Zuhair Mohammad Hassan2Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 1411713116, IranDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 1411713116, IranDepartment of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 1411713116, IranColorectal cancer is the third most common cancer in the world. Due to the side effects of common treatments such as chemotherapy and radiotherapy, the use of herbal medicines has received much attention. Artemether (ARM) is an herbal medicine derived from artemisinin, which has many anti-tumor properties. However, factors such as low solubility and short half-life have limited the use of artemether in clinical practice. In this study, we aimed to reduce these limitations by encapsulating artemether in human serum albumin (HSA). The hydrodynamic diameter and the zeta potential value of ARM-ALB nanoparticles (NPs) were 171.3 ± 5.88 nm and −19.1 ± 0.82 mV, respectively. Comparison of the effect of free and encapsulated artemether on CT 26 cell line showed that the use of artemether in capsulated form can reduce the effective concentration of the drug. Additionally, in vivo studies have also shown that albumin–artemether nanoparticles can control tumor growth by increasing the production of cytokine IFN-γ and decreasing the production of IL4. Therefore, ARM-ALB nanoparticles have greater anti-tumor effects than free artemether.https://www.mdpi.com/2227-9059/10/11/2713colorectal cancerartemetheralbumin–artemether nanoparticles |
| spellingShingle | Zeynab Pirali-Hamedani Ardeshir Abbasi Zuhair Mohammad Hassan Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer Effects Biomedicines colorectal cancer artemether albumin–artemether nanoparticles |
| title | Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer Effects |
| title_full | Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer Effects |
| title_fullStr | Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer Effects |
| title_full_unstemmed | Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer Effects |
| title_short | Synthesis of Artemether-Loaded Albumin Nanoparticles and Measurement of Their Anti-Cancer Effects |
| title_sort | synthesis of artemether loaded albumin nanoparticles and measurement of their anti cancer effects |
| topic | colorectal cancer artemether albumin–artemether nanoparticles |
| url | https://www.mdpi.com/2227-9059/10/11/2713 |
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