Salivary creatinine and urea are higher in an experimental model of acute but not chronic renal disease.
Plasma creatinine and urea are commonly used markers of kidney function in both acute and chronic renal failure. The needed repeated blood collection is associated with pain, stress and might lead to infections. Saliva has the potential to be a non-invasive alternative diagnostic fluid. The use of s...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC6034877?pdf=render |
| _version_ | 1828301663685836800 |
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| author | Alexandra Kovalčíková Katarína Janšáková Marianna Gyurászová Ľudmila Podracká Katarína Šebeková Peter Celec Ľubomíra Tóthová |
| author_facet | Alexandra Kovalčíková Katarína Janšáková Marianna Gyurászová Ľudmila Podracká Katarína Šebeková Peter Celec Ľubomíra Tóthová |
| author_sort | Alexandra Kovalčíková |
| collection | DOAJ |
| description | Plasma creatinine and urea are commonly used markers of kidney function in both acute and chronic renal failure. The needed repeated blood collection is associated with pain, stress and might lead to infections. Saliva has the potential to be a non-invasive alternative diagnostic fluid. The use of saliva in clinical practice is limited, since many factors affect the concentration of salivary biomarkers. The aim of our study was to analyze salivary creatinine and urea in the animal models of acute and chronic renal disease. Bilateral nephrectomy and adenine nephropathy were induced in adult male mice. Both, plasma creatinine and urea were higher in animals with renal failure compared to controls. Salivary creatinine was higher by 81% and salivary urea by 43% in comparison to the control group, but only in animals with bilateral nephrectomy and not in adenine nephropathy. Our results indicate that the increase of salivary creatinine and urea depends on the experimental model of renal failure and its severity. Further studies are needed to monitor the dynamics of salivary markers of renal function and to reveal determinants of their variability. |
| first_indexed | 2024-04-13T13:26:19Z |
| format | Article |
| id | doaj.art-8c65ca5a43da44dfb63ce2fcce432cee |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T13:26:19Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8c65ca5a43da44dfb63ce2fcce432cee2022-12-22T02:45:07ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01137e020039110.1371/journal.pone.0200391Salivary creatinine and urea are higher in an experimental model of acute but not chronic renal disease.Alexandra KovalčíkováKatarína JanšákováMarianna GyurászováĽudmila PodrackáKatarína ŠebekováPeter CelecĽubomíra TóthováPlasma creatinine and urea are commonly used markers of kidney function in both acute and chronic renal failure. The needed repeated blood collection is associated with pain, stress and might lead to infections. Saliva has the potential to be a non-invasive alternative diagnostic fluid. The use of saliva in clinical practice is limited, since many factors affect the concentration of salivary biomarkers. The aim of our study was to analyze salivary creatinine and urea in the animal models of acute and chronic renal disease. Bilateral nephrectomy and adenine nephropathy were induced in adult male mice. Both, plasma creatinine and urea were higher in animals with renal failure compared to controls. Salivary creatinine was higher by 81% and salivary urea by 43% in comparison to the control group, but only in animals with bilateral nephrectomy and not in adenine nephropathy. Our results indicate that the increase of salivary creatinine and urea depends on the experimental model of renal failure and its severity. Further studies are needed to monitor the dynamics of salivary markers of renal function and to reveal determinants of their variability.http://europepmc.org/articles/PMC6034877?pdf=render |
| spellingShingle | Alexandra Kovalčíková Katarína Janšáková Marianna Gyurászová Ľudmila Podracká Katarína Šebeková Peter Celec Ľubomíra Tóthová Salivary creatinine and urea are higher in an experimental model of acute but not chronic renal disease. PLoS ONE |
| title | Salivary creatinine and urea are higher in an experimental model of acute but not chronic renal disease. |
| title_full | Salivary creatinine and urea are higher in an experimental model of acute but not chronic renal disease. |
| title_fullStr | Salivary creatinine and urea are higher in an experimental model of acute but not chronic renal disease. |
| title_full_unstemmed | Salivary creatinine and urea are higher in an experimental model of acute but not chronic renal disease. |
| title_short | Salivary creatinine and urea are higher in an experimental model of acute but not chronic renal disease. |
| title_sort | salivary creatinine and urea are higher in an experimental model of acute but not chronic renal disease |
| url | http://europepmc.org/articles/PMC6034877?pdf=render |
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