Effect of β-cyclodextrin on the hemocompatibility of heparin-modified PMP hollow fibrous membrane for Extracorporeal Membrane Oxygenation (ECMO)
In this paper, modified membranes containing β-cyclodextrin (β-CD) and heparin coatings were prepared on the surface of poly-4-methyl-1-pentene (PMP) hollow fibrous membrane using the high strength adhesion of polydopamine (PDA). In this paper, β-CD was added to increase the hemocompatibility of the...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Medicine in Novel Technology and Devices |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590093523000243 |
| _version_ | 1797790841050234880 |
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| author | Xingrui Zhong Ting He Zhaohui Wang Yawei Wang Linhao Li Zhaoliang Cui |
| author_facet | Xingrui Zhong Ting He Zhaohui Wang Yawei Wang Linhao Li Zhaoliang Cui |
| author_sort | Xingrui Zhong |
| collection | DOAJ |
| description | In this paper, modified membranes containing β-cyclodextrin (β-CD) and heparin coatings were prepared on the surface of poly-4-methyl-1-pentene (PMP) hollow fibrous membrane using the high strength adhesion of polydopamine (PDA). In this paper, β-CD was added to increase the hemocompatibility of the PMP hollow fibrous membranes and the stability of the heparin coating. The uniformity of the heparin coating with β-CD addition was better than that of the groups without β-CD. After seven days of saline rinsing, the surface of the modified membranes with β-CD addition still had a large amount of heparin present, which was more stable compared to the control group. After surface modification, the modified membrane changed from hydrophobic to hydrophilic. Importantly, the protein adsorption, platelet adhesion, and hemolysis rates of the modified membranes were significantly reduced compared with the pristine membranes. The APTT values were also significantly increased. The results showed that the modified membranes with the addition of β-CD had better hydrophilicity, can maintain the stability of heparin coating for a long time, and finally showed good hemocompatibility. |
| first_indexed | 2024-03-13T02:10:15Z |
| format | Article |
| id | doaj.art-8c68080eedd64b2aa676b2325a767037 |
| institution | Directory Open Access Journal |
| issn | 2590-0935 |
| language | English |
| last_indexed | 2024-03-13T02:10:15Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Medicine in Novel Technology and Devices |
| spelling | doaj.art-8c68080eedd64b2aa676b2325a7670372023-07-01T04:35:35ZengElsevierMedicine in Novel Technology and Devices2590-09352023-06-0118100229Effect of β-cyclodextrin on the hemocompatibility of heparin-modified PMP hollow fibrous membrane for Extracorporeal Membrane Oxygenation (ECMO)Xingrui Zhong0Ting He1Zhaohui Wang2Yawei Wang3Linhao Li4Zhaoliang Cui5State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing, 210009, China; National Engineering Research Center for Special Separation Membrane, Nanjing Tech University, Nanjing, 210009, ChinaState Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing, 210009, China; National Engineering Research Center for Special Separation Membrane, Nanjing Tech University, Nanjing, 210009, ChinaState Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing, 210009, China; National Engineering Research Center for Special Separation Membrane, Nanjing Tech University, Nanjing, 210009, China; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, 210009, ChinaBeijing Aerospace Changfeng Co., Ltd., Beijing, 100854, ChinaKey Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, 100083, China; Corresponding author.State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing, 210009, China; National Engineering Research Center for Special Separation Membrane, Nanjing Tech University, Nanjing, 210009, China; Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University, Nanjing, 210009, China; Corresponding author. Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Centre for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, ChinaIn this paper, modified membranes containing β-cyclodextrin (β-CD) and heparin coatings were prepared on the surface of poly-4-methyl-1-pentene (PMP) hollow fibrous membrane using the high strength adhesion of polydopamine (PDA). In this paper, β-CD was added to increase the hemocompatibility of the PMP hollow fibrous membranes and the stability of the heparin coating. The uniformity of the heparin coating with β-CD addition was better than that of the groups without β-CD. After seven days of saline rinsing, the surface of the modified membranes with β-CD addition still had a large amount of heparin present, which was more stable compared to the control group. After surface modification, the modified membrane changed from hydrophobic to hydrophilic. Importantly, the protein adsorption, platelet adhesion, and hemolysis rates of the modified membranes were significantly reduced compared with the pristine membranes. The APTT values were also significantly increased. The results showed that the modified membranes with the addition of β-CD had better hydrophilicity, can maintain the stability of heparin coating for a long time, and finally showed good hemocompatibility.http://www.sciencedirect.com/science/article/pii/S2590093523000243β-cyclodextrinHeparinDopamineHemocompatibility |
| spellingShingle | Xingrui Zhong Ting He Zhaohui Wang Yawei Wang Linhao Li Zhaoliang Cui Effect of β-cyclodextrin on the hemocompatibility of heparin-modified PMP hollow fibrous membrane for Extracorporeal Membrane Oxygenation (ECMO) Medicine in Novel Technology and Devices β-cyclodextrin Heparin Dopamine Hemocompatibility |
| title | Effect of β-cyclodextrin on the hemocompatibility of heparin-modified PMP hollow fibrous membrane for Extracorporeal Membrane Oxygenation (ECMO) |
| title_full | Effect of β-cyclodextrin on the hemocompatibility of heparin-modified PMP hollow fibrous membrane for Extracorporeal Membrane Oxygenation (ECMO) |
| title_fullStr | Effect of β-cyclodextrin on the hemocompatibility of heparin-modified PMP hollow fibrous membrane for Extracorporeal Membrane Oxygenation (ECMO) |
| title_full_unstemmed | Effect of β-cyclodextrin on the hemocompatibility of heparin-modified PMP hollow fibrous membrane for Extracorporeal Membrane Oxygenation (ECMO) |
| title_short | Effect of β-cyclodextrin on the hemocompatibility of heparin-modified PMP hollow fibrous membrane for Extracorporeal Membrane Oxygenation (ECMO) |
| title_sort | effect of β cyclodextrin on the hemocompatibility of heparin modified pmp hollow fibrous membrane for extracorporeal membrane oxygenation ecmo |
| topic | β-cyclodextrin Heparin Dopamine Hemocompatibility |
| url | http://www.sciencedirect.com/science/article/pii/S2590093523000243 |
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