Perinatal Management of Pregnancy Complicated by Autosomal Dominant Emery–Dreifuss Muscular Dystrophy
Abstract Introduction Autosomal dominant Emery–Dreifuss muscular dystrophy (AD-EDMD) is rare compared with other forms of muscular dystrophy and is characterized by cardiac conduction defects. Here, we present the case of a patient diagnosed with AD-EDMD during the first trimester of pr...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Thieme Medical Publishers, Inc.
2016-03-01
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| Series: | American Journal of Perinatology Reports |
| Subjects: | |
| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1581058 |
| _version_ | 1818851216277372928 |
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| author | Megumi Sato Hiromitsu Shirasawa Kenichi Makino Hiroshi Miura Wataru Sato Dai Shimizu Naoki Sato Jin Kumagai Akira Sato Yukihiro Terada |
| author_facet | Megumi Sato Hiromitsu Shirasawa Kenichi Makino Hiroshi Miura Wataru Sato Dai Shimizu Naoki Sato Jin Kumagai Akira Sato Yukihiro Terada |
| author_sort | Megumi Sato |
| collection | DOAJ |
| description | Abstract
Introduction Autosomal dominant Emery–Dreifuss muscular dystrophy (AD-EDMD) is rare compared with other forms of muscular dystrophy and is characterized by cardiac conduction defects. Here, we present the case of a patient diagnosed with AD-EDMD during the first trimester of pregnancy who developed acute preeclampsia and subsequently, congestive heart failure (CHF) following cesarean section.
Case A 36-year-old, gravida 0 para 0 woman was diagnosed with AD-EDMD by genetic testing during the first trimester of pregnancy, and she suddenly developed preeclampsia and partial HELLP (hemolytic anemia, elevated liver enzymes, and low platelets) syndrome at 33 weeks of gestation. The patient subsequently developed CHF following cesarean section.
Conclusion CHF can occur as a direct result of the cardiac defects arising due to EDMD, and therefore, careful prenatal and postpartum management is recommended for such cases. |
| first_indexed | 2024-12-19T07:01:30Z |
| format | Article |
| id | doaj.art-8c685abe9d24439dba51087c330f2b0e |
| institution | Directory Open Access Journal |
| issn | 2157-6998 2157-7005 |
| language | English |
| last_indexed | 2024-12-19T07:01:30Z |
| publishDate | 2016-03-01 |
| publisher | Thieme Medical Publishers, Inc. |
| record_format | Article |
| series | American Journal of Perinatology Reports |
| spelling | doaj.art-8c685abe9d24439dba51087c330f2b0e2022-12-21T20:31:24ZengThieme Medical Publishers, Inc.American Journal of Perinatology Reports2157-69982157-70052016-03-010601e145e14710.1055/s-0036-1581058Perinatal Management of Pregnancy Complicated by Autosomal Dominant Emery–Dreifuss Muscular DystrophyMegumi Sato0Hiromitsu Shirasawa1Kenichi Makino2Hiroshi Miura3Wataru Sato4Dai Shimizu5Naoki Sato6Jin Kumagai7Akira Sato8Yukihiro Terada9Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, JapanDepartment of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, JapanDepartment of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, JapanDepartment of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, JapanDepartment of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, JapanDepartment of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, JapanDepartment of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, JapanDepartment of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, JapanDepartment of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, JapanDepartment of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, JapanAbstract Introduction Autosomal dominant Emery–Dreifuss muscular dystrophy (AD-EDMD) is rare compared with other forms of muscular dystrophy and is characterized by cardiac conduction defects. Here, we present the case of a patient diagnosed with AD-EDMD during the first trimester of pregnancy who developed acute preeclampsia and subsequently, congestive heart failure (CHF) following cesarean section. Case A 36-year-old, gravida 0 para 0 woman was diagnosed with AD-EDMD by genetic testing during the first trimester of pregnancy, and she suddenly developed preeclampsia and partial HELLP (hemolytic anemia, elevated liver enzymes, and low platelets) syndrome at 33 weeks of gestation. The patient subsequently developed CHF following cesarean section. Conclusion CHF can occur as a direct result of the cardiac defects arising due to EDMD, and therefore, careful prenatal and postpartum management is recommended for such cases.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1581058emeri–dreifuss muscular dystrophypreeclampsiacongestive heart failurehellp syndrome |
| spellingShingle | Megumi Sato Hiromitsu Shirasawa Kenichi Makino Hiroshi Miura Wataru Sato Dai Shimizu Naoki Sato Jin Kumagai Akira Sato Yukihiro Terada Perinatal Management of Pregnancy Complicated by Autosomal Dominant Emery–Dreifuss Muscular Dystrophy American Journal of Perinatology Reports emeri–dreifuss muscular dystrophy preeclampsia congestive heart failure hellp syndrome |
| title | Perinatal Management of Pregnancy Complicated by Autosomal Dominant Emery–Dreifuss Muscular Dystrophy |
| title_full | Perinatal Management of Pregnancy Complicated by Autosomal Dominant Emery–Dreifuss Muscular Dystrophy |
| title_fullStr | Perinatal Management of Pregnancy Complicated by Autosomal Dominant Emery–Dreifuss Muscular Dystrophy |
| title_full_unstemmed | Perinatal Management of Pregnancy Complicated by Autosomal Dominant Emery–Dreifuss Muscular Dystrophy |
| title_short | Perinatal Management of Pregnancy Complicated by Autosomal Dominant Emery–Dreifuss Muscular Dystrophy |
| title_sort | perinatal management of pregnancy complicated by autosomal dominant emery dreifuss muscular dystrophy |
| topic | emeri–dreifuss muscular dystrophy preeclampsia congestive heart failure hellp syndrome |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0036-1581058 |
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