What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits?
Information exchange is a critical process in all communication systems, including biological ones. Retroactivity describes the load that downstream modules apply to their upstream systems in biological circuits. The motivation behind this work is that of integrating retroactivity, a concept proper...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/27/10/3130 |
| _version_ | 1827667578620739584 |
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| author | Francesca Ratti Maurizio Magarini Domitilla Del Vecchio |
| author_facet | Francesca Ratti Maurizio Magarini Domitilla Del Vecchio |
| author_sort | Francesca Ratti |
| collection | DOAJ |
| description | Information exchange is a critical process in all communication systems, including biological ones. Retroactivity describes the load that downstream modules apply to their upstream systems in biological circuits. The motivation behind this work is that of integrating retroactivity, a concept proper of biochemical circuits, with the metrics defined in Information Theory and Digital Communications. This paper focuses on studying the impact of retroactivity on different biological signaling system models, which present analogies with well-known telecommunication systems. The mathematical analysis is performed both in the high and low molecular counts regime, by mean of the Chemical Master Equation and the Linear Noise Approximation, respectively. The main goal of this work is to provide analytical tools to maximize the reliable information exchange across different biomolecular circuit models. Results highlight how, in general, retroactivity harms communication performance. This negative effect can be mitigated by adding to the signaling circuit an independent upstream system that connects with the same pool of downstream circuits. |
| first_indexed | 2024-03-10T03:20:17Z |
| format | Article |
| id | doaj.art-8c6ac597b27b4fffb5c5b3921f798b68 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T03:20:17Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8c6ac597b27b4fffb5c5b3921f798b682023-11-23T12:21:30ZengMDPI AGMolecules1420-30492022-05-012710313010.3390/molecules27103130What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits?Francesca Ratti0Maurizio Magarini1Domitilla Del Vecchio2Mechanical Engineering Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USADepartment of Information, Electronics, and Bioengineering, Politecnico di Milano, 20133 Milan, ItalyMechanical Engineering Department, Massachusetts Institute of Technology, Cambridge, MA 02139, USAInformation exchange is a critical process in all communication systems, including biological ones. Retroactivity describes the load that downstream modules apply to their upstream systems in biological circuits. The motivation behind this work is that of integrating retroactivity, a concept proper of biochemical circuits, with the metrics defined in Information Theory and Digital Communications. This paper focuses on studying the impact of retroactivity on different biological signaling system models, which present analogies with well-known telecommunication systems. The mathematical analysis is performed both in the high and low molecular counts regime, by mean of the Chemical Master Equation and the Linear Noise Approximation, respectively. The main goal of this work is to provide analytical tools to maximize the reliable information exchange across different biomolecular circuit models. Results highlight how, in general, retroactivity harms communication performance. This negative effect can be mitigated by adding to the signaling circuit an independent upstream system that connects with the same pool of downstream circuits.https://www.mdpi.com/1420-3049/27/10/3130molecular communicationmutual informationsystems biologysynthetic biologycommunication systemsretroactivity |
| spellingShingle | Francesca Ratti Maurizio Magarini Domitilla Del Vecchio What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits? Molecules molecular communication mutual information systems biology synthetic biology communication systems retroactivity |
| title | What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits? |
| title_full | What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits? |
| title_fullStr | What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits? |
| title_full_unstemmed | What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits? |
| title_short | What Is the Trait d’Union between Retroactivity and Molecular Communication Performance Limits? |
| title_sort | what is the trait d union between retroactivity and molecular communication performance limits |
| topic | molecular communication mutual information systems biology synthetic biology communication systems retroactivity |
| url | https://www.mdpi.com/1420-3049/27/10/3130 |
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