Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats
Objective(s): The Ischemia/reperfusion (I/R) phenomenon has a critical role in brain injuries induced by some kinds of stroke. The current study investigates the effects of Coenzyme Q10 (Q10) on global cerebral I/R in rats. Materials and Methods: Fifty male Wistar rats were used in this study. The g...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2022-01-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_19479_633a23e10bdc1197b280a50703e94750.pdf |
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| author | Iman Fatemi Pooya Saeed Askari Elham Hakimizadeh Ayat Kaeidi Sogand Esmaeil-Moghaddam Mohammad Pak-Hashemi Mohammad Allahtavakoli |
| author_facet | Iman Fatemi Pooya Saeed Askari Elham Hakimizadeh Ayat Kaeidi Sogand Esmaeil-Moghaddam Mohammad Pak-Hashemi Mohammad Allahtavakoli |
| author_sort | Iman Fatemi |
| collection | DOAJ |
| description | Objective(s): The Ischemia/reperfusion (I/R) phenomenon has a critical role in brain injuries induced by some kinds of stroke. The current study investigates the effects of Coenzyme Q10 (Q10) on global cerebral I/R in rats. Materials and Methods: Fifty male Wistar rats were used in this study. The global cerebral I/R was induced by obstructing both common carotid arteries for 20 min and the animals were treated with Q10 (200 mg/kg; PO.) for 6 weeks. Depressive and anxiety-like behaviors were assessed using the elevated plus-maze and forced swimming test, respectively. Working and spatial learning and memory were assessed by the Y-maze continuous alternation task and Morris water maze. The brain tissues were evaluated for brain edema, brain-derived neurotrophic factor (BDNF) levels, and superoxide dismutase (SOD) activities. Results: Our results indicated that global cerebral I/R increased anxiety and depression-like behavior as well as reduced cognitive performance. Moreover, the levels of BDNF and activities of SOD are reduced in stroke animals. Chronic post-stroke treatment with Q10 decreased brain edema. Furthermore, Q10 administration reduced anxiety and depressive-like behavior as well as cognitive impairments in stroke animals. Q10 also increased the SOD activities and BDNF levels in the brain tissues of stroke animals. Conclusion: Finally, we can conclude that using Q10 supplementation may be beneficial against the global cerebral I/R complications. |
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| format | Article |
| id | doaj.art-8c6c50e5554b4adfb79d9283c568dbb4 |
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| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-12-23T06:11:45Z |
| publishDate | 2022-01-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-8c6c50e5554b4adfb79d9283c568dbb42022-12-21T17:57:26ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742022-01-01251394510.22038/ijbms.2022.57630.1286519479Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in ratsIman Fatemi0Pooya Saeed Askari1Elham Hakimizadeh2Ayat Kaeidi3Sogand Esmaeil-Moghaddam4Mohammad Pak-Hashemi5Mohammad Allahtavakoli6Research Center of Tropical and Infectious Diseases, Kerman University of Medical Sciences, Kerman, IranStudent Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, IranPhysiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, IranPhysiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, IranStudent Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, IranStudent Research Committee, Rafsanjan University of Medical Sciences, Rafsanjan, IranPhysiology-Pharmacology Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, IranObjective(s): The Ischemia/reperfusion (I/R) phenomenon has a critical role in brain injuries induced by some kinds of stroke. The current study investigates the effects of Coenzyme Q10 (Q10) on global cerebral I/R in rats. Materials and Methods: Fifty male Wistar rats were used in this study. The global cerebral I/R was induced by obstructing both common carotid arteries for 20 min and the animals were treated with Q10 (200 mg/kg; PO.) for 6 weeks. Depressive and anxiety-like behaviors were assessed using the elevated plus-maze and forced swimming test, respectively. Working and spatial learning and memory were assessed by the Y-maze continuous alternation task and Morris water maze. The brain tissues were evaluated for brain edema, brain-derived neurotrophic factor (BDNF) levels, and superoxide dismutase (SOD) activities. Results: Our results indicated that global cerebral I/R increased anxiety and depression-like behavior as well as reduced cognitive performance. Moreover, the levels of BDNF and activities of SOD are reduced in stroke animals. Chronic post-stroke treatment with Q10 decreased brain edema. Furthermore, Q10 administration reduced anxiety and depressive-like behavior as well as cognitive impairments in stroke animals. Q10 also increased the SOD activities and BDNF levels in the brain tissues of stroke animals. Conclusion: Finally, we can conclude that using Q10 supplementation may be beneficial against the global cerebral I/R complications.https://ijbms.mums.ac.ir/article_19479_633a23e10bdc1197b280a50703e94750.pdfbrain injuriesfree radicalsischemia/reperfusionq10rat |
| spellingShingle | Iman Fatemi Pooya Saeed Askari Elham Hakimizadeh Ayat Kaeidi Sogand Esmaeil-Moghaddam Mohammad Pak-Hashemi Mohammad Allahtavakoli Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats Iranian Journal of Basic Medical Sciences brain injuries free radicals ischemia/reperfusion q10 rat |
| title | Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats |
| title_full | Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats |
| title_fullStr | Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats |
| title_full_unstemmed | Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats |
| title_short | Chronic treatment with coenzyme Q10 mitigates the behavioral dysfunction of global cerebral ischemia/reperfusion injury in rats |
| title_sort | chronic treatment with coenzyme q10 mitigates the behavioral dysfunction of global cerebral ischemia reperfusion injury in rats |
| topic | brain injuries free radicals ischemia/reperfusion q10 rat |
| url | https://ijbms.mums.ac.ir/article_19479_633a23e10bdc1197b280a50703e94750.pdf |
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