Inflammasome lights up in systemic sclerosis
Abstract Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement dependent on the NLRP3 inflammasome. This links epigenetic events with inflammasome sig...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | Arthritis Research & Therapy |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13075-017-1420-z |
| _version_ | 1811221348275453952 |
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| author | John Henderson Steven O’Reilly |
| author_facet | John Henderson Steven O’Reilly |
| author_sort | John Henderson |
| collection | DOAJ |
| description | Abstract Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement dependent on the NLRP3 inflammasome. This links epigenetic events with inflammasome signalling in SSc and opens the door to new therapeutic strategies for the treatment of SSc. |
| first_indexed | 2024-04-12T07:57:50Z |
| format | Article |
| id | doaj.art-8c6cbfa68175400ba4212d7006963286 |
| institution | Directory Open Access Journal |
| issn | 1478-6362 |
| language | English |
| last_indexed | 2024-04-12T07:57:50Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Arthritis Research & Therapy |
| spelling | doaj.art-8c6cbfa68175400ba4212d70069632862022-12-22T03:41:25ZengBMCArthritis Research & Therapy1478-63622017-09-011911210.1186/s13075-017-1420-zInflammasome lights up in systemic sclerosisJohn Henderson0Steven O’Reilly1Immunology group, Faculty of Health and Life Sciences, Northumbria UniversityImmunology group, Faculty of Health and Life Sciences, Northumbria UniversityAbstract Systemic sclerosis (SSc) is a pro-fibrotic condition with a poorly understood aetiology. Evidence presented by Artlett et al. in this issue suggests that the microRNA miR-155 is key, with its involvement dependent on the NLRP3 inflammasome. This links epigenetic events with inflammasome signalling in SSc and opens the door to new therapeutic strategies for the treatment of SSc.http://link.springer.com/article/10.1186/s13075-017-1420-zSclerosisFibrosisInflammasomemicroRNAEpigeneticsInterleukin-1 |
| spellingShingle | John Henderson Steven O’Reilly Inflammasome lights up in systemic sclerosis Arthritis Research & Therapy Sclerosis Fibrosis Inflammasome microRNA Epigenetics Interleukin-1 |
| title | Inflammasome lights up in systemic sclerosis |
| title_full | Inflammasome lights up in systemic sclerosis |
| title_fullStr | Inflammasome lights up in systemic sclerosis |
| title_full_unstemmed | Inflammasome lights up in systemic sclerosis |
| title_short | Inflammasome lights up in systemic sclerosis |
| title_sort | inflammasome lights up in systemic sclerosis |
| topic | Sclerosis Fibrosis Inflammasome microRNA Epigenetics Interleukin-1 |
| url | http://link.springer.com/article/10.1186/s13075-017-1420-z |
| work_keys_str_mv | AT johnhenderson inflammasomelightsupinsystemicsclerosis AT stevenoreilly inflammasomelightsupinsystemicsclerosis |