Reinfection rate in a cohort of healthcare workers over 2 years of the COVID-19 pandemic
Abstract In this large cohort of healthcare workers, we aimed to estimate the rate of reinfections by SARS-CoV-2 over 2 years of the COVID-19 pandemic. We investigated the proportion of reinfections among all the cases of SARS-CoV-2 infection from March 10, 2020 until March 10, 2022. Reinfection was...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-25908-6 |
| _version_ | 1797952560496115712 |
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| author | Ana Rubia Guedes Maura S. Oliveira Bruno M. Tavares Alessandra Luna-Muschi Carolina dos Santos Lazari Amanda C. Montal Elizabeth de Faria Fernando Liebhart Maia Antonio dos Santos Barboza Mariana Deckers Leme Francis M. Tomazini Silvia Figueiredo Costa Anna S. Levin |
| author_facet | Ana Rubia Guedes Maura S. Oliveira Bruno M. Tavares Alessandra Luna-Muschi Carolina dos Santos Lazari Amanda C. Montal Elizabeth de Faria Fernando Liebhart Maia Antonio dos Santos Barboza Mariana Deckers Leme Francis M. Tomazini Silvia Figueiredo Costa Anna S. Levin |
| author_sort | Ana Rubia Guedes |
| collection | DOAJ |
| description | Abstract In this large cohort of healthcare workers, we aimed to estimate the rate of reinfections by SARS-CoV-2 over 2 years of the COVID-19 pandemic. We investigated the proportion of reinfections among all the cases of SARS-CoV-2 infection from March 10, 2020 until March 10, 2022. Reinfection was defined as the appearance of new symptoms that on medical evaluation were suggestive of COVID-19 and confirmed by a positive RT-PCR. Symptoms had to occur more than 90 days after the previous infection. These 2 years were divided into time periods based on the different variants of concern (VOC) in the city of São Paulo. There were 37,729 medical consultations due to COVID-19 at the hospital’s Health Workers Services; and 25,750 RT-PCR assays were performed, of which 23% (n = 5865) were positive. Reinfection by SARS-CoV-2 was identified in 5% (n = 284) of symptomatic cases. Most cases of reinfection occurred during the Omicron period (n = 251; 88%), representing a significant increase on the SARS-CoV-2 reinfection rate before and during the Omicron variant period (0.8% vs. 4.3%; p < 0.001). The mean interval between SARS-CoV-2 infections was 429 days (ranged from 122 to 674). The Omicron variant spread faster than Gamma and Delta variant. All SARS-CoV-2 reinfections were mild cases. |
| first_indexed | 2024-04-10T22:48:19Z |
| format | Article |
| id | doaj.art-8c715096edda4ef09812dbcc8f77b28e |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-10T22:48:19Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-8c715096edda4ef09812dbcc8f77b28e2023-01-15T12:11:09ZengNature PortfolioScientific Reports2045-23222023-01-011311510.1038/s41598-022-25908-6Reinfection rate in a cohort of healthcare workers over 2 years of the COVID-19 pandemicAna Rubia Guedes0Maura S. Oliveira1Bruno M. Tavares2Alessandra Luna-Muschi3Carolina dos Santos Lazari4Amanda C. Montal5Elizabeth de Faria6Fernando Liebhart Maia7Antonio dos Santos Barboza8Mariana Deckers Leme9Francis M. Tomazini10Silvia Figueiredo Costa11Anna S. Levin12Infection Control Department, Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloInfection Control Department, Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloInfection Control Department, Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloInstituto de Medicina Tropical, Faculdade de Medicina, Universidade de São PauloCentral Laboratory Division, Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloCentral Administration of Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloCentral Administration of Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloHealthcare Worker Health Services, Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloHealthcare Worker Health Services, Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloHealthcare Worker Health Services, Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloCentral Administration of Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloInstituto de Medicina Tropical, Faculdade de Medicina, Universidade de São PauloInfection Control Department, Hospital das Clinicas, Faculdade de Medicina, Universidade de São PauloAbstract In this large cohort of healthcare workers, we aimed to estimate the rate of reinfections by SARS-CoV-2 over 2 years of the COVID-19 pandemic. We investigated the proportion of reinfections among all the cases of SARS-CoV-2 infection from March 10, 2020 until March 10, 2022. Reinfection was defined as the appearance of new symptoms that on medical evaluation were suggestive of COVID-19 and confirmed by a positive RT-PCR. Symptoms had to occur more than 90 days after the previous infection. These 2 years were divided into time periods based on the different variants of concern (VOC) in the city of São Paulo. There were 37,729 medical consultations due to COVID-19 at the hospital’s Health Workers Services; and 25,750 RT-PCR assays were performed, of which 23% (n = 5865) were positive. Reinfection by SARS-CoV-2 was identified in 5% (n = 284) of symptomatic cases. Most cases of reinfection occurred during the Omicron period (n = 251; 88%), representing a significant increase on the SARS-CoV-2 reinfection rate before and during the Omicron variant period (0.8% vs. 4.3%; p < 0.001). The mean interval between SARS-CoV-2 infections was 429 days (ranged from 122 to 674). The Omicron variant spread faster than Gamma and Delta variant. All SARS-CoV-2 reinfections were mild cases.https://doi.org/10.1038/s41598-022-25908-6 |
| spellingShingle | Ana Rubia Guedes Maura S. Oliveira Bruno M. Tavares Alessandra Luna-Muschi Carolina dos Santos Lazari Amanda C. Montal Elizabeth de Faria Fernando Liebhart Maia Antonio dos Santos Barboza Mariana Deckers Leme Francis M. Tomazini Silvia Figueiredo Costa Anna S. Levin Reinfection rate in a cohort of healthcare workers over 2 years of the COVID-19 pandemic Scientific Reports |
| title | Reinfection rate in a cohort of healthcare workers over 2 years of the COVID-19 pandemic |
| title_full | Reinfection rate in a cohort of healthcare workers over 2 years of the COVID-19 pandemic |
| title_fullStr | Reinfection rate in a cohort of healthcare workers over 2 years of the COVID-19 pandemic |
| title_full_unstemmed | Reinfection rate in a cohort of healthcare workers over 2 years of the COVID-19 pandemic |
| title_short | Reinfection rate in a cohort of healthcare workers over 2 years of the COVID-19 pandemic |
| title_sort | reinfection rate in a cohort of healthcare workers over 2 years of the covid 19 pandemic |
| url | https://doi.org/10.1038/s41598-022-25908-6 |
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