<i>Candida auris</i> Bloodstream Infections in Russia
<i>Candida auris</i>—a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases of <i>C. auris</i> bloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Antibiotics |
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| Online Access: | https://www.mdpi.com/2079-6382/9/9/557 |
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| author | Natalia E. Barantsevich Antonina V. Vetokhina Natalia I. Ayushinova Olga E. Orlova Elena P. Barantsevich |
| author_facet | Natalia E. Barantsevich Antonina V. Vetokhina Natalia I. Ayushinova Olga E. Orlova Elena P. Barantsevich |
| author_sort | Natalia E. Barantsevich |
| collection | DOAJ |
| description | <i>Candida auris</i>—a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases of <i>C. auris</i> bloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering predisposing factors, antifungal susceptibility of isolates, treatment, and outcomes. Interhospital transfers of patients and labor migration contributed to the spread of <i>C. auris</i>. The South Asian lineage of the studied strains was indicated by K143R substitution in <i>ERG11</i> gene and phylogenetic analysis of internal transcribed spacer and D1-D2 domain. All isolates from <i>C. auris</i> candidemia cases were susceptible to echinocandins. High-level resistance to fluconazole and resistance to amphotericin B were present in the majority of strains. The overall all-cause mortality rate in <i>C. auris</i> bloodstream infections was 55.3% and the 30-day all-cause mortality rate 39.5%. The attributable mortality was 0%. Eradication of <i>C. auris</i> from blood was associated with the favourable outcomes in patients. It was achieved irrespective of whether antifungal preparations within or outside the susceptibility range were administered. Further international surveillance and studies providing consensus guidelines for the management of <i>C. auris</i> infections are needed. |
| first_indexed | 2024-03-10T16:43:02Z |
| format | Article |
| id | doaj.art-8c73b302c9c14eeebc6f2886920ef449 |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T16:43:02Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-8c73b302c9c14eeebc6f2886920ef4492023-11-20T11:52:58ZengMDPI AGAntibiotics2079-63822020-08-019955710.3390/antibiotics9090557<i>Candida auris</i> Bloodstream Infections in RussiaNatalia E. Barantsevich0Antonina V. Vetokhina1Natalia I. Ayushinova2Olga E. Orlova3Elena P. Barantsevich4Almazov National Medical Research Centre, 2 Akkuratova str., 197341 St. Petersburg, RussiaAlmazov National Medical Research Centre, 2 Akkuratova str., 197341 St. Petersburg, RussiaAlmazov National Medical Research Centre, 2 Akkuratova str., 197341 St. Petersburg, RussiaAlmazov National Medical Research Centre, 2 Akkuratova str., 197341 St. Petersburg, RussiaAlmazov National Medical Research Centre, 2 Akkuratova str., 197341 St. Petersburg, Russia<i>Candida auris</i>—a fungus (yeast) that can cause hospital outbreaks was first recognized in 2009. The authors report data on 38 cases of <i>C. auris</i> bloodstream infections in multidisciplinary hospitals situated in two distantly located regions of Russia, considering predisposing factors, antifungal susceptibility of isolates, treatment, and outcomes. Interhospital transfers of patients and labor migration contributed to the spread of <i>C. auris</i>. The South Asian lineage of the studied strains was indicated by K143R substitution in <i>ERG11</i> gene and phylogenetic analysis of internal transcribed spacer and D1-D2 domain. All isolates from <i>C. auris</i> candidemia cases were susceptible to echinocandins. High-level resistance to fluconazole and resistance to amphotericin B were present in the majority of strains. The overall all-cause mortality rate in <i>C. auris</i> bloodstream infections was 55.3% and the 30-day all-cause mortality rate 39.5%. The attributable mortality was 0%. Eradication of <i>C. auris</i> from blood was associated with the favourable outcomes in patients. It was achieved irrespective of whether antifungal preparations within or outside the susceptibility range were administered. Further international surveillance and studies providing consensus guidelines for the management of <i>C. auris</i> infections are needed.https://www.mdpi.com/2079-6382/9/9/557treatmentechinocandinsazolessusceptibilityamphotericin Bmortality |
| spellingShingle | Natalia E. Barantsevich Antonina V. Vetokhina Natalia I. Ayushinova Olga E. Orlova Elena P. Barantsevich <i>Candida auris</i> Bloodstream Infections in Russia Antibiotics treatment echinocandins azoles susceptibility amphotericin B mortality |
| title | <i>Candida auris</i> Bloodstream Infections in Russia |
| title_full | <i>Candida auris</i> Bloodstream Infections in Russia |
| title_fullStr | <i>Candida auris</i> Bloodstream Infections in Russia |
| title_full_unstemmed | <i>Candida auris</i> Bloodstream Infections in Russia |
| title_short | <i>Candida auris</i> Bloodstream Infections in Russia |
| title_sort | i candida auris i bloodstream infections in russia |
| topic | treatment echinocandins azoles susceptibility amphotericin B mortality |
| url | https://www.mdpi.com/2079-6382/9/9/557 |
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