New ST623 of Cryptococcus neoformans isolated from a patient with non-Hodgkin’s lymphoma in the Brazilian Amazon
Abstract Background Cryptococcosis is a disease of wide geographic distribution. It is most critical when it affects immunocompromised patients, with AIDS, tuberculosis or other diseases that require prolonged hospitalization. Methods This study described a case report, molecular epidemiology, the p...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2020-05-01
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| Series: | Annals of Clinical Microbiology and Antimicrobials |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12941-020-00361-3 |
| _version_ | 1818852489754050560 |
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| author | Lucyane Mendes Silva William Antunes Ferreira Roberto Alexandre Alves Barbosa Filho Marcus Vinícius Guimarães Lacerda Guilherme Motta Antunes Ferreira Maria de Nazaré Saunier Marielle Machado Macedo Denise de Almeida Cristo Marla Jalene Alves Ani Beatriz Jackisch-Matsuura Cristina Motta Ferreira |
| author_facet | Lucyane Mendes Silva William Antunes Ferreira Roberto Alexandre Alves Barbosa Filho Marcus Vinícius Guimarães Lacerda Guilherme Motta Antunes Ferreira Maria de Nazaré Saunier Marielle Machado Macedo Denise de Almeida Cristo Marla Jalene Alves Ani Beatriz Jackisch-Matsuura Cristina Motta Ferreira |
| author_sort | Lucyane Mendes Silva |
| collection | DOAJ |
| description | Abstract Background Cryptococcosis is a disease of wide geographic distribution. It is most critical when it affects immunocompromised patients, with AIDS, tuberculosis or other diseases that require prolonged hospitalization. Methods This study described a case report, molecular epidemiology, the phylogenetic relationship, along with antifungal susceptibility test of a new ST 623 of C. neoformans isolated in a patient with non-Hodgkin’s Lymphoma, from Manaus, Brazil. Results The new C. neoformans was susceptible to all antifungal drugs tested. Our results showed that ST623 new clone has no evident evolutionary proximity to any other ST of the VNI subtype group identified in Brazil. Conclusions In the context of phylogenetic analysis, this new genotype belongs to VNI subtype, and subsequencing complete genome studies are necessary to better understand the phylogenetic relationships amongst STs in this group. |
| first_indexed | 2024-12-19T07:21:44Z |
| format | Article |
| id | doaj.art-8c7412830fd645b6b276ba106f462528 |
| institution | Directory Open Access Journal |
| issn | 1476-0711 |
| language | English |
| last_indexed | 2024-12-19T07:21:44Z |
| publishDate | 2020-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Annals of Clinical Microbiology and Antimicrobials |
| spelling | doaj.art-8c7412830fd645b6b276ba106f4625282022-12-21T20:30:55ZengBMCAnnals of Clinical Microbiology and Antimicrobials1476-07112020-05-011911510.1186/s12941-020-00361-3New ST623 of Cryptococcus neoformans isolated from a patient with non-Hodgkin’s lymphoma in the Brazilian AmazonLucyane Mendes Silva0William Antunes Ferreira1Roberto Alexandre Alves Barbosa Filho2Marcus Vinícius Guimarães Lacerda3Guilherme Motta Antunes Ferreira4Maria de Nazaré Saunier5Marielle Machado Macedo6Denise de Almeida Cristo7Marla Jalene Alves8Ani Beatriz Jackisch-Matsuura9Cristina Motta Ferreira10Fundação Hospitalar de Hematologia e Hemoterapia do Amazonas–HEMOAMUniversidade do Estado do Amazonas-UEAUniversidade Federal do Amazonas-UFAMFundação de Medicina Tropical Dr. Heitor Vieira DouradoFundação Hospitalar de Hematologia e Hemoterapia do Amazonas–HEMOAMFundação Hospitalar de Hematologia e Hemoterapia do Amazonas–HEMOAMFundação Hospitalar de Hematologia e Hemoterapia do Amazonas–HEMOAMFundação Hospitalar de Hematologia e Hemoterapia do Amazonas–HEMOAMInstituto Leônidas e Maria-Deane, FIOCRUZInstituto Leônidas e Maria-Deane, FIOCRUZFundação Hospitalar de Hematologia e Hemoterapia do Amazonas–HEMOAMAbstract Background Cryptococcosis is a disease of wide geographic distribution. It is most critical when it affects immunocompromised patients, with AIDS, tuberculosis or other diseases that require prolonged hospitalization. Methods This study described a case report, molecular epidemiology, the phylogenetic relationship, along with antifungal susceptibility test of a new ST 623 of C. neoformans isolated in a patient with non-Hodgkin’s Lymphoma, from Manaus, Brazil. Results The new C. neoformans was susceptible to all antifungal drugs tested. Our results showed that ST623 new clone has no evident evolutionary proximity to any other ST of the VNI subtype group identified in Brazil. Conclusions In the context of phylogenetic analysis, this new genotype belongs to VNI subtype, and subsequencing complete genome studies are necessary to better understand the phylogenetic relationships amongst STs in this group.http://link.springer.com/article/10.1186/s12941-020-00361-3PhylogenyC. neorformansMLSTNon-Hodgkin diseaseST623 |
| spellingShingle | Lucyane Mendes Silva William Antunes Ferreira Roberto Alexandre Alves Barbosa Filho Marcus Vinícius Guimarães Lacerda Guilherme Motta Antunes Ferreira Maria de Nazaré Saunier Marielle Machado Macedo Denise de Almeida Cristo Marla Jalene Alves Ani Beatriz Jackisch-Matsuura Cristina Motta Ferreira New ST623 of Cryptococcus neoformans isolated from a patient with non-Hodgkin’s lymphoma in the Brazilian Amazon Annals of Clinical Microbiology and Antimicrobials Phylogeny C. neorformans MLST Non-Hodgkin disease ST623 |
| title | New ST623 of Cryptococcus neoformans isolated from a patient with non-Hodgkin’s lymphoma in the Brazilian Amazon |
| title_full | New ST623 of Cryptococcus neoformans isolated from a patient with non-Hodgkin’s lymphoma in the Brazilian Amazon |
| title_fullStr | New ST623 of Cryptococcus neoformans isolated from a patient with non-Hodgkin’s lymphoma in the Brazilian Amazon |
| title_full_unstemmed | New ST623 of Cryptococcus neoformans isolated from a patient with non-Hodgkin’s lymphoma in the Brazilian Amazon |
| title_short | New ST623 of Cryptococcus neoformans isolated from a patient with non-Hodgkin’s lymphoma in the Brazilian Amazon |
| title_sort | new st623 of cryptococcus neoformans isolated from a patient with non hodgkin s lymphoma in the brazilian amazon |
| topic | Phylogeny C. neorformans MLST Non-Hodgkin disease ST623 |
| url | http://link.springer.com/article/10.1186/s12941-020-00361-3 |
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