Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch

Folding behavior of a T-shaped, ribosome-binding translation enhancer implicated in a wide-spread conformational switch

Turnip crinkle virus contains a T-shaped, ribosome-binding, translation enhancer (TSS) in its 3’UTR that serves as a hub for interactions throughout the region. The viral RNA-dependent RNA polymerase (RdRp) causes the TSS/surrounding region to undergo a conformational shift postulated to inhibit tra...

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Bibliographic Details
Main Authors: My-Tra Le, Wojciech K Kasprzak, Taejin Kim, Feng Gao, Megan YL Young, Xuefeng Yuan, Bruce A Shapiro, Joonil Seog, Anne E Simon
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-02-01
Series:eLife
Subjects:
optical tweezers
RNA structure
Turnip crinkle virus
molecular dynamics
RNA virus
Online Access:https://elifesciences.org/articles/22883

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