Multiorgan neutrophilic inflammation in a Border Collie with “trapped” neutrophil syndrome
Abstract Trapped neutrophil syndrome is a rare congenital disease recognized in Border Collies and is characterized by persistent neutropenia with myeloid hyperplasia. The mechanism of neutropenia has not been described. We document the case of a young Border Collie diagnosed with trapped neutrophil...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2022-11-01
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| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.16567 |
| _version_ | 1797976867063463936 |
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| author | Alyssa Zoto Chelsea Stecklein Michael A. Scott Thomas R. Bauer Jr. Cynthia Lucidi Harry Cridge |
| author_facet | Alyssa Zoto Chelsea Stecklein Michael A. Scott Thomas R. Bauer Jr. Cynthia Lucidi Harry Cridge |
| author_sort | Alyssa Zoto |
| collection | DOAJ |
| description | Abstract Trapped neutrophil syndrome is a rare congenital disease recognized in Border Collies and is characterized by persistent neutropenia with myeloid hyperplasia. The mechanism of neutropenia has not been described. We document the case of a young Border Collie diagnosed with trapped neutrophil syndrome based on clinical features, blood and bone marrow evaluation, and presence of the associated homozygous mutation. Results from flow cytometric and storage studies suggested lower neutrophil survival time. The dog had substantial neutrophilic inflammation in multiple organs, indicating that neutrophils could leave the marrow and enter tissues, making the term “trapped” neutrophil syndrome a misnomer. |
| first_indexed | 2024-04-11T04:57:48Z |
| format | Article |
| id | doaj.art-8c753085808b43699a0e21176720e377 |
| institution | Directory Open Access Journal |
| issn | 0891-6640 1939-1676 |
| language | English |
| last_indexed | 2024-04-11T04:57:48Z |
| publishDate | 2022-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj.art-8c753085808b43699a0e21176720e3772022-12-26T07:32:23ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762022-11-013662170217610.1111/jvim.16567Multiorgan neutrophilic inflammation in a Border Collie with “trapped” neutrophil syndromeAlyssa Zoto0Chelsea Stecklein1Michael A. Scott2Thomas R. Bauer Jr.3Cynthia Lucidi4Harry Cridge5Department of Small Animal Clinical Sciences, College of Veterinary Medicine Michigan State University East Lansing Michigan USADepartment of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine Michigan State University East Lansing Michigan USADepartment of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine Michigan State University East Lansing Michigan USAImmune Deficiency—Cellular Therapy Program, National Cancer Institute National Institutes of Health Bethesda Maryland USAVeterinary Diagnostic Laboratory, College of Veterinary Medicine Michigan State University Lansing Michigan USADepartment of Small Animal Clinical Sciences, College of Veterinary Medicine Michigan State University East Lansing Michigan USAAbstract Trapped neutrophil syndrome is a rare congenital disease recognized in Border Collies and is characterized by persistent neutropenia with myeloid hyperplasia. The mechanism of neutropenia has not been described. We document the case of a young Border Collie diagnosed with trapped neutrophil syndrome based on clinical features, blood and bone marrow evaluation, and presence of the associated homozygous mutation. Results from flow cytometric and storage studies suggested lower neutrophil survival time. The dog had substantial neutrophilic inflammation in multiple organs, indicating that neutrophils could leave the marrow and enter tissues, making the term “trapped” neutrophil syndrome a misnomer.https://doi.org/10.1111/jvim.16567bone marrowCohen syndromeineffective myelopoiesisneutropeniaVPS13B |
| spellingShingle | Alyssa Zoto Chelsea Stecklein Michael A. Scott Thomas R. Bauer Jr. Cynthia Lucidi Harry Cridge Multiorgan neutrophilic inflammation in a Border Collie with “trapped” neutrophil syndrome Journal of Veterinary Internal Medicine bone marrow Cohen syndrome ineffective myelopoiesis neutropenia VPS13B |
| title | Multiorgan neutrophilic inflammation in a Border Collie with “trapped” neutrophil syndrome |
| title_full | Multiorgan neutrophilic inflammation in a Border Collie with “trapped” neutrophil syndrome |
| title_fullStr | Multiorgan neutrophilic inflammation in a Border Collie with “trapped” neutrophil syndrome |
| title_full_unstemmed | Multiorgan neutrophilic inflammation in a Border Collie with “trapped” neutrophil syndrome |
| title_short | Multiorgan neutrophilic inflammation in a Border Collie with “trapped” neutrophil syndrome |
| title_sort | multiorgan neutrophilic inflammation in a border collie with trapped neutrophil syndrome |
| topic | bone marrow Cohen syndrome ineffective myelopoiesis neutropenia VPS13B |
| url | https://doi.org/10.1111/jvim.16567 |
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