Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7

Respiratory dysfunction in a mouse model of spinocerebellar ataxia type 7

Spinocerebellar ataxia type 7 (SCA7) is an autosomal-dominant neurodegenerative disorder caused by a CAG repeat expansion in the coding region of the ataxin-7 gene. Infantile-onset SCA7 patients display extremely large repeat expansions (>200 CAGs) and exhibit progressive ataxia, dysarthria, dysp...

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Bibliographic Details
Main Authors: Anna F. Fusco, Logan A. Pucci, Pawel M. Switonski, Debolina D. Biswas, Angela L. McCall, Amanda F. Kahn, Justin S. Dhindsa, Laura M. Strickland, Albert R. La Spada, Mai K. ElMallah
Format: Article
Language:English
Published: The Company of Biologists 2021-07-01
Series:Disease Models & Mechanisms
Subjects:
sca7
spinocerebellar ataxia type 7
respiratory
phrenic
hypoglossal
Online Access:http://dmm.biologists.org/content/14/7/dmm048893

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