Use of Cytopoint in the Allergic Dog
Allergic dermatitis is the most common type of skin disease in dogs. Of all dogs, 20 to 30% present with some type of allergic dermatitis. Pruritus is one of the most important signs of allergic dermatitis and is often the most challenging to control. Interleukin-31 (IL-31) has been found to be one...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2022.909776/full |
| _version_ | 1811218646628827136 |
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| author | Margaret Gober Andrew Hillier Manuel A. Vasquez-Hidalgo Manuel A. Vasquez-Hidalgo Deborah Amodie Martha A. Mellencamp |
| author_facet | Margaret Gober Andrew Hillier Manuel A. Vasquez-Hidalgo Manuel A. Vasquez-Hidalgo Deborah Amodie Martha A. Mellencamp |
| author_sort | Margaret Gober |
| collection | DOAJ |
| description | Allergic dermatitis is the most common type of skin disease in dogs. Of all dogs, 20 to 30% present with some type of allergic dermatitis. Pruritus is one of the most important signs of allergic dermatitis and is often the most challenging to control. Interleukin-31 (IL-31) has been found to be one of the main initiators of pruritus in dogs with allergic dermatitis. Cytopoint®, a caninized monoclonal anti-IL-31 antibody, has been shown to be effective for the treatment of dogs against allergic dermatitis and atopic dermatitis. US label indication. A recent retrospective study reported that Cytopoint achieved treatment success in 87.8% of the cases with allergic dermatitis. No prospective cohort studies have been performed investigating the effects of Cytopoint in dogs with allergic dermatitis using the dosing protocol prescribed on the product label in the United States. In this study, our objectives were to assess the efficacy of Cytopoint for treatment of canine allergic dermatitis of variable etiologies and management of the associated pruritus, and add to the body of evidence available to the veterinarian as they make treatment recommendations. Dogs included in this study had moderate to severe pruritus according to the Pruritus Visual Analog Scale (PVAS; ≥ 50 mm) and a history of likely continuation of pruritus at the time of presentation. On day 0, investigators recorded the initial body weight and every patient received one dose of Cytopoint (minimum 2 mg/kg SQ) and an isoxazoline product for parasite control. Treatment success for this study was defined as a ≥20 mm reduction in PVAS from Day 0. On Day 7, 94% of the dogs had achieved treatment success. On Day 28, 98% had achieved treatment success and cumulatively by day 56, 100% of the dogs achieved treatment success. This prospective study provides evidence that Cytopoint effectively treats dogs with allergic dermatitis of different types and the associated pruritus. |
| first_indexed | 2024-04-12T07:12:54Z |
| format | Article |
| id | doaj.art-8c77dd1b6d2041b78152b4f97d4b525d |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-04-12T07:12:54Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-8c77dd1b6d2041b78152b4f97d4b525d2022-12-22T03:42:34ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692022-07-01910.3389/fvets.2022.909776909776Use of Cytopoint in the Allergic DogMargaret Gober0Andrew Hillier1Manuel A. Vasquez-Hidalgo2Manuel A. Vasquez-Hidalgo3Deborah Amodie4Martha A. Mellencamp5Zoetis, Inc., Parsippany, NJ, United StatesZoetis, Inc., Parsippany, NJ, United StatesZoetis, Inc., Parsippany, NJ, United StatesDepartment of Animal Sciences, North Dakota State University, Fargo, ND, United StatesZoetis, Inc., Parsippany, NJ, United StatesZoetis, Inc., Parsippany, NJ, United StatesAllergic dermatitis is the most common type of skin disease in dogs. Of all dogs, 20 to 30% present with some type of allergic dermatitis. Pruritus is one of the most important signs of allergic dermatitis and is often the most challenging to control. Interleukin-31 (IL-31) has been found to be one of the main initiators of pruritus in dogs with allergic dermatitis. Cytopoint®, a caninized monoclonal anti-IL-31 antibody, has been shown to be effective for the treatment of dogs against allergic dermatitis and atopic dermatitis. US label indication. A recent retrospective study reported that Cytopoint achieved treatment success in 87.8% of the cases with allergic dermatitis. No prospective cohort studies have been performed investigating the effects of Cytopoint in dogs with allergic dermatitis using the dosing protocol prescribed on the product label in the United States. In this study, our objectives were to assess the efficacy of Cytopoint for treatment of canine allergic dermatitis of variable etiologies and management of the associated pruritus, and add to the body of evidence available to the veterinarian as they make treatment recommendations. Dogs included in this study had moderate to severe pruritus according to the Pruritus Visual Analog Scale (PVAS; ≥ 50 mm) and a history of likely continuation of pruritus at the time of presentation. On day 0, investigators recorded the initial body weight and every patient received one dose of Cytopoint (minimum 2 mg/kg SQ) and an isoxazoline product for parasite control. Treatment success for this study was defined as a ≥20 mm reduction in PVAS from Day 0. On Day 7, 94% of the dogs had achieved treatment success. On Day 28, 98% had achieved treatment success and cumulatively by day 56, 100% of the dogs achieved treatment success. This prospective study provides evidence that Cytopoint effectively treats dogs with allergic dermatitis of different types and the associated pruritus.https://www.frontiersin.org/articles/10.3389/fvets.2022.909776/fulllokivetmaballergic dermatitisdogspruritusanti-IL-31 |
| spellingShingle | Margaret Gober Andrew Hillier Manuel A. Vasquez-Hidalgo Manuel A. Vasquez-Hidalgo Deborah Amodie Martha A. Mellencamp Use of Cytopoint in the Allergic Dog Frontiers in Veterinary Science lokivetmab allergic dermatitis dogs pruritus anti-IL-31 |
| title | Use of Cytopoint in the Allergic Dog |
| title_full | Use of Cytopoint in the Allergic Dog |
| title_fullStr | Use of Cytopoint in the Allergic Dog |
| title_full_unstemmed | Use of Cytopoint in the Allergic Dog |
| title_short | Use of Cytopoint in the Allergic Dog |
| title_sort | use of cytopoint in the allergic dog |
| topic | lokivetmab allergic dermatitis dogs pruritus anti-IL-31 |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2022.909776/full |
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