Langerhans cell histiocytosis in an adult patient
Aim: to present a clinical case of a rare dermatosis — Langerhans cell histiocytosis (LCH) in an adult patient.Materials and methods. A clinical and laboratory examination of a 64-year-old woman who had complained of rashes on the skin of the scalp, neck, trunk and lower extremities accompanied by i...
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| Format: | Article |
| Language: | English |
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State Scientific Center of Dermatovenereology and Cosmetology
2019-10-01
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| Series: | Vestnik Dermatologii i Venerologii |
| Subjects: | |
| Online Access: | https://www.vestnikdv.ru/jour/article/view/505 |
| _version_ | 1797763222985506816 |
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| author | A. E. Karamova V. V. Chikin L. F. Znamenskaya M. A. Nefedova V. A. Mikhina N. S. Battalova |
| author_facet | A. E. Karamova V. V. Chikin L. F. Znamenskaya M. A. Nefedova V. A. Mikhina N. S. Battalova |
| author_sort | A. E. Karamova |
| collection | DOAJ |
| description | Aim: to present a clinical case of a rare dermatosis — Langerhans cell histiocytosis (LCH) in an adult patient.Materials and methods. A clinical and laboratory examination of a 64-year-old woman who had complained of rashes on the skin of the scalp, neck, trunk and lower extremities accompanied by itching was carried out. A histological study of skin biopsy samples from the lesion area, as well as an immunohistochemical study of Langerhans cell markers — langerin and S-100 protein — were performed.Results. Clinical manifestations of the disease, the presence of histiocytic infiltrate in the epidermis and dermis during the histological study and immunohistochemical detection of langerin infiltrate cells and S-100 protein were all consistent with the diagnosis of LCH. The therapy with methotrexate subcutaneously significantly improved the patient’s condition.Conclusion. Verification of the LCH diagnosis requires a histological study of skin biopsy samples and an immunohistochemical study of Langerhans cell markers. The efficacy of methotrexate in the treatment of this disease has been confirmed. |
| first_indexed | 2024-03-12T19:38:30Z |
| format | Article |
| id | doaj.art-8c78417ba2214eb1bac8429c65cac9b6 |
| institution | Directory Open Access Journal |
| issn | 0042-4609 2313-6294 |
| language | English |
| last_indexed | 2024-03-12T19:38:30Z |
| publishDate | 2019-10-01 |
| publisher | State Scientific Center of Dermatovenereology and Cosmetology |
| record_format | Article |
| series | Vestnik Dermatologii i Venerologii |
| spelling | doaj.art-8c78417ba2214eb1bac8429c65cac9b62023-08-02T03:59:56ZengState Scientific Center of Dermatovenereology and CosmetologyVestnik Dermatologii i Venerologii0042-46092313-62942019-10-01954576610.25208/0042-4609-2019-95-4-57-66444Langerhans cell histiocytosis in an adult patientA. E. Karamova0V. V. Chikin1L. F. Znamenskaya2M. A. Nefedova3V. A. Mikhina4N. S. Battalova5State Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian FederationState Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian FederationState Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian FederationState Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian FederationState Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian FederationState Research Center of Dermatovenereology and Cosmetology, Ministry of Health of the Russian FederationAim: to present a clinical case of a rare dermatosis — Langerhans cell histiocytosis (LCH) in an adult patient.Materials and methods. A clinical and laboratory examination of a 64-year-old woman who had complained of rashes on the skin of the scalp, neck, trunk and lower extremities accompanied by itching was carried out. A histological study of skin biopsy samples from the lesion area, as well as an immunohistochemical study of Langerhans cell markers — langerin and S-100 protein — were performed.Results. Clinical manifestations of the disease, the presence of histiocytic infiltrate in the epidermis and dermis during the histological study and immunohistochemical detection of langerin infiltrate cells and S-100 protein were all consistent with the diagnosis of LCH. The therapy with methotrexate subcutaneously significantly improved the patient’s condition.Conclusion. Verification of the LCH diagnosis requires a histological study of skin biopsy samples and an immunohistochemical study of Langerhans cell markers. The efficacy of methotrexate in the treatment of this disease has been confirmed.https://www.vestnikdv.ru/jour/article/view/505langerhans cell histiocytosishistiocytesmethotrexate |
| spellingShingle | A. E. Karamova V. V. Chikin L. F. Znamenskaya M. A. Nefedova V. A. Mikhina N. S. Battalova Langerhans cell histiocytosis in an adult patient Vestnik Dermatologii i Venerologii langerhans cell histiocytosis histiocytes methotrexate |
| title | Langerhans cell histiocytosis in an adult patient |
| title_full | Langerhans cell histiocytosis in an adult patient |
| title_fullStr | Langerhans cell histiocytosis in an adult patient |
| title_full_unstemmed | Langerhans cell histiocytosis in an adult patient |
| title_short | Langerhans cell histiocytosis in an adult patient |
| title_sort | langerhans cell histiocytosis in an adult patient |
| topic | langerhans cell histiocytosis histiocytes methotrexate |
| url | https://www.vestnikdv.ru/jour/article/view/505 |
| work_keys_str_mv | AT aekaramova langerhanscellhistiocytosisinanadultpatient AT vvchikin langerhanscellhistiocytosisinanadultpatient AT lfznamenskaya langerhanscellhistiocytosisinanadultpatient AT manefedova langerhanscellhistiocytosisinanadultpatient AT vamikhina langerhanscellhistiocytosisinanadultpatient AT nsbattalova langerhanscellhistiocytosisinanadultpatient |