Novel Frog Skin-Derived Peptide Dermaseptin-PP for Lung Cancer Treatment: In vitro/vivo Evaluation and Anti-tumor Mechanisms Study

Novel Frog Skin-Derived Peptide Dermaseptin-PP for Lung Cancer Treatment: In vitro/vivo Evaluation and Anti-tumor Mechanisms Study

Lung cancer is the major cause of cancer deaths worldwide, and it has the highest incidence and mortality rate of any cancer among men and women in China. The first-line therapy for lung cancer treatment is platinum-based chemotherapy drugs such as cisplatin. However, the application of present chem...

Full description

Bibliographic Details
Main Authors:	Ziyi Dong, Haiyan Hu, Xianglong Yu, Li Tan, Chengbang Ma, Xinping Xi, Lei Li, Lei Wang, Mei Zhou, Tianbao Chen, Shouying Du, Yang Lu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-06-01
Series:	Frontiers in Chemistry
Subjects:	novel peptide discovery molecular cloning peptide synthesis anti-lung cancer membrane destruction apoptosis
Online Access:	https://www.frontiersin.org/article/10.3389/fchem.2020.00476/full

Similar Items

Evaluating the Bioactivity of a Novel Antimicrobial and Anticancer Peptide, Dermaseptin-PS4(Der-PS4), from the Skin Secretion of <i>Phyllomedusa sauvagii</i>
by: Dong Chen, et al.
Published: (2019-08-01)

Two Novel Dermaseptin-Like Antimicrobial Peptides with Anticancer Activities from the Skin Secretion of Pachymedusa dacnicolor
by: Daning Shi, et al.
Published: (2016-05-01)

Baltikinin: A New Myotropic Tryptophyllin-3 Peptide Isolated from the Skin Secretion of the Purple-Sided Leaf Frog, Phyllomedusa baltea
by: Daning Shi, et al.
Published: (2016-07-01)

A Novel Antimicrobial Peptide, Dermaseptin-SS1, with Anti-Proliferative Activity, Isolated from the Skin Secretion of <i>Phyllomedusa tarsius</i>
by: Xiaonan Ma, et al.
Published: (2023-09-01)

Discovery of two skin-derived dermaseptins and design of a TAT-fusion analogue with broad-spectrum antimicrobial activity and low cytotoxicity on healthy cells
by: Haohao Zhu, et al.
Published: (2018-09-01)

Identification and Rational Design of a Novel Antibacterial Peptide Dermaseptin-AC from the Skin Secretion of the Red-Eyed Tree Frog <i>Agalychnis callidryas</i>
by: Zijian Gong, et al.
Published: (2020-05-01)

Phylloseptin-PBa—A Novel Broad-Spectrum Antimicrobial Peptide from the Skin Secretion of the Peruvian Purple-Sided Leaf Frog (Phyllomedusa Baltea) Which Exhibits Cancer Cell Cytotoxicity
by: Yuantai Wan, et al.
Published: (2015-12-01)

Dermaseptin-PH: A Novel Peptide with Antimicrobial and Anticancer Activities from the Skin Secretion of the South American Orange-Legged Leaf Frog, Pithecopus (Phyllomedusa) hypochondrialis
by: Linyuan Huang, et al.
Published: (2017-10-01)

Bioevaluation and Targeted Modification of Temporin-FL From the Skin Secretion of Dark-Spotted Frog (Pelophylax nigromaculatus)
by: Wenjie Wang, et al.
Published: (2021-10-01)

A Novel Antimicrobial Peptide (Kassinatuerin-3) Isolated from the Skin Secretion of the African Frog, <i>Kassina senegalensis</i>
by: Hui Wang, et al.
Published: (2020-07-01)

LFB: A Novel Antimicrobial Brevinin-Like Peptide from the Skin Secretion of the Fujian Large Headed Frog, <i>Limnonectes fujianensi</i>
by: Bin Li, et al.
Published: (2019-06-01)

Biological Activities of Cationicity-Enhanced and Hydrophobicity-Optimized Analogues of an Antimicrobial Peptide, Dermaseptin-PS3, from the Skin Secretion of Phyllomedusa sauvagii
by: Yining Tan, et al.
Published: (2018-08-01)

Exploration of the Structure–Function Relationships of a Novel Frog Skin Secretion-Derived Bioactive Peptide, t-DPH1, through Use of Rational Design, Cationicity Enhancement and In Vitro Studies
by: Haixin Qin, et al.
Published: (2021-12-01)

Design of N-Terminal Derivatives from a Novel Dermaseptin Exhibiting Broad-Spectrum Antimicrobial Activity against Isolates from Cystic Fibrosis Patients
by: Yuan Ying, et al.
Published: (2019-10-01)

Design of novel analogues of t-DPH1 with reduced cytotoxicity, taking the three conserved characteristics of the dermaseptin family as the feasible starting point
by: Haixin Qin, et al.
Published: (2024-01-01)

Evaluating the Bioactivity of a Novel Broad-Spectrum Antimicrobial Peptide Brevinin-1GHa from the Frog Skin Secretion of Hylarana guentheri and Its Analogues
by: Qi Chen, et al.
Published: (2018-10-01)

Pharmacological Effects of Two Novel Bombesin-Like Peptides from the Skin Secretions of Chinese Piebald Odorous Frog (Odorrana schmackeri) and European Edible Frog (Pelophylax kl. esculentus) on Smooth Muscle
by: Xiaowei Zhou, et al.
Published: (2017-10-01)

Identification and molecular cloning of novel antimicrobial peptides from skin secretions of the Chinese bamboo leaf odorous frog (Odorrana versabilis) and the North American pickerel frog (Rana palustris)
by: Yali Wu, et al.
Published: (2017-07-01)

Discovery of Distinctin-Like-Peptide-PH (DLP-PH) From the Skin Secretion of Phyllomedusa hypochondrialis, a Prototype of a Novel Family of Antimicrobial Peptide
by: Di Wu, et al.
Published: (2018-03-01)

Identification of a Novel Vasodilatory Octapeptide from the Skin Secretion of the African Hyperoliid Frog, Kassina senegalensis
by: Qiang Du, et al.
Published: (2017-07-01)

AaeAP1 and AaeAP2: Novel Antimicrobial Peptides from the Venom of the Scorpion, Androctonus aeneas: Structural Characterisation, Molecular Cloning of Biosynthetic Precursor-Encoding cDNAs and Engineering of Analogues with Enhanced Antimicrobial and Anticancer Activities
by: Qiang Du, et al.
Published: (2015-01-01)

A <i>Hylarana latouchii</i> Skin Secretion-Derived Novel Bombesin-Related Pentadecapeptide (Ranatensin-HLa) Evoke Myotropic Effects on the in vitro Rat Smooth Muscles
by: Yan Lin, et al.
Published: (2019-04-01)

Broad-Spectrum Antimicrobial Activity and Improved Stability of a D-Amino Acid Enantiomer of DMPC-10A, the Designed Derivative of Dermaseptin Truncates
by: Yu Zai, et al.
Published: (2020-09-01)

Pharmacological Effects of a Novel Bradykinin-Related Peptide (RR-18) from the Skin Secretion of the Hejiang Frog (<i>Ordorrana hejiangensis</i>) on Smooth Muscle
by: Xiaowei Zhou, et al.
Published: (2020-07-01)

Recent Advances in Multifunctional Antimicrobial Peptides as Immunomodulatory and Anticancer Therapy: Chromogranin A-Derived Peptides and Dermaseptins as Endogenous versus Exogenous Actors
by: Francesco Scavello, et al.
Published: (2022-09-01)

Exploring the active core of a novel antimicrobial peptide, palustrin-2LTb, from the Kuatun frog, Hylarana latouchii, using a bioinformatics-directed approach
by: Wanchen Zou, et al.
Published: (2022-01-01)

Bioevaluation of Ranatuerin-2Pb from the Frog Skin Secretion of <i>Rana pipiens</i> and Its Truncated Analogues
by: Xiaowei Zhou, et al.
Published: (2019-06-01)

De novo sequencing of two novel peptides homologous to calcitonin-like peptides, from skin secretion of the Chinese Frog, Odorrana schmackeri
by: Geisa P.C. Evaristo, et al.
Published: (2015-09-01)

Discovery and analysis of a novel antimicrobial peptide B1AW from the skin secretion of Amolops wuyiensis and improving the membrane-binding affinity through the construction of the lysine-introduced analogue
by: Haixin Qin, et al.
Published: (2023-01-01)

Discovery of Novel Bacterial Cell-Penetrating Phylloseptins in Defensive Skin Secretions of the South American Hylid Frogs, Phyllomedusa duellmani and Phyllomedusa coelestis
by: Nan Yang, et al.
Published: (2016-08-01)

Engineering and Structural Insights of a Novel BBI-like Protease Inhibitor Livisin from the Frog Skin Secretion
by: Jie Yang, et al.
Published: (2022-04-01)

Temporins: Multifunctional Peptides from Frog Skin
by: Luca Domenico D'Andrea, et al.
Published: (2023-03-01)

Identification and Characterisation of the Antimicrobial Peptide, Phylloseptin-PT, from the Skin Secretion of Phyllomedusa tarsius, and Comparison of Activity with Designed, Cationicity-Enhanced Analogues and Diastereomers
by: Yitian Gao, et al.
Published: (2016-12-01)

PSN-PC: A Novel Antimicrobial and Anti-Biofilm Peptide from the Skin Secretion of Phyllomedusa-camba with Cytotoxicity on Human Lung Cancer Cell
by: Xianhui Wu, et al.
Published: (2017-11-01)

The Potential of Frog Skin-Derived Peptides for Development into Therapeutically-Valuable Immunomodulatory Agents
by: Jelena M. Pantic, et al.
Published: (2017-12-01)

Discovery and Rational Design of a Novel Bowman-Birk Related Protease Inhibitor
by: Yuxi Miao, et al.
Published: (2019-07-01)

Study on the Structure-Activity Relationship of an Antimicrobial Peptide, Brevinin-2GUb, from the Skin Secretion of <i>Hylarana guentheri</i>
by: Yaxian Lin, et al.
Published: (2021-07-01)

Antitumor Activity and Mechanism of Action of Hormonotoxin, an LHRH Analog Conjugated to Dermaseptin-B2, a Multifunctional Antimicrobial Peptide
by: Mickael Couty, et al.
Published: (2021-10-01)

Virtual Screening of Peptide Libraries: The Search for Peptide-Based Therapeutics Using Computational Tools
by: Marian Vincenzi, et al.
Published: (2024-02-01)

Generation of truncated derivatives through in silico enzymatic digest of peptide GV30 target MRSA both in vitro and in vivo
by: Yingxue Ma, et al.
Published: (2021-01-01)