The prevalence of primary angle closure glaucoma in adult Asians: a systematic review and meta-analysis.
Primary angle closure glaucoma (PACG) is higher in Asians than Europeans and Africans, with over 80% of PACG worldwide in Asia. Previous estimates of PACG were based largely on early studies, mostly using inappropriate case definitions. Therefore, we did a systematic review and meta-analysis to esti...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4110010?pdf=render |
| _version_ | 1819068966022152192 |
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| author | Jin-Wei Cheng Ying Zong You-Yan Zeng Rui-Li Wei |
| author_facet | Jin-Wei Cheng Ying Zong You-Yan Zeng Rui-Li Wei |
| author_sort | Jin-Wei Cheng |
| collection | DOAJ |
| description | Primary angle closure glaucoma (PACG) is higher in Asians than Europeans and Africans, with over 80% of PACG worldwide in Asia. Previous estimates of PACG were based largely on early studies, mostly using inappropriate case definitions. Therefore, we did a systematic review and meta-analysis to estimate the prevalence of PACG in adult Asian populations and to quantify its association with age, gender, and region.All primary reports of population-based studies that reported the prevalence of PACG in adult Asian populations were identified. PACG case definition was compatible with the ISGEO definition. Twenty-nine population-based studies were included. The overall pooled prevalence estimates were calculated using a random effect model, and ethnicity-, age- and gender-specific pooled prevalence estimates were also calculated.The overall pooled prevalence of PACG in those of adult Asians was 0.75% (95% CI, 0.58, 0.96). Ethnicity-specific pooled prevalence estimates were 0.97% (0.22, 4.27) in Middle East group, 0.66% (0.23, 1.86) in South East Asia group, 0.46% (0.32, 0.64) in India group, 1.10% (0.85, 1.44) in China group, and 1.19% (0.35, 3.98) in Japan group, respectively. Age-specific prevalence was 0.21% (0.12, 0.37) for those 40-49 years, 0.54% (0.34, 0.85) for those 50-59 years, 1.26% (0.93, 1.71) for those 60-69 years, and 2.32% (1.74, 3.08) for those 70 years or above. The overall female to male ratio of the PACG prevalence was 1.51∶1 (95% CI 1.01, 2.28).PACG affects approximately 0.75% adult Asians, increasing double per decade, and 60% of cases being female. The prevalence rates vary greatly by ethnic region. |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T16:42:32Z |
| publishDate | 2014-01-01 |
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| series | PLoS ONE |
| spelling | doaj.art-8c7a4443d23046298470700d9aeec9a02022-12-21T18:57:05ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0197e10322210.1371/journal.pone.0103222The prevalence of primary angle closure glaucoma in adult Asians: a systematic review and meta-analysis.Jin-Wei ChengYing ZongYou-Yan ZengRui-Li WeiPrimary angle closure glaucoma (PACG) is higher in Asians than Europeans and Africans, with over 80% of PACG worldwide in Asia. Previous estimates of PACG were based largely on early studies, mostly using inappropriate case definitions. Therefore, we did a systematic review and meta-analysis to estimate the prevalence of PACG in adult Asian populations and to quantify its association with age, gender, and region.All primary reports of population-based studies that reported the prevalence of PACG in adult Asian populations were identified. PACG case definition was compatible with the ISGEO definition. Twenty-nine population-based studies were included. The overall pooled prevalence estimates were calculated using a random effect model, and ethnicity-, age- and gender-specific pooled prevalence estimates were also calculated.The overall pooled prevalence of PACG in those of adult Asians was 0.75% (95% CI, 0.58, 0.96). Ethnicity-specific pooled prevalence estimates were 0.97% (0.22, 4.27) in Middle East group, 0.66% (0.23, 1.86) in South East Asia group, 0.46% (0.32, 0.64) in India group, 1.10% (0.85, 1.44) in China group, and 1.19% (0.35, 3.98) in Japan group, respectively. Age-specific prevalence was 0.21% (0.12, 0.37) for those 40-49 years, 0.54% (0.34, 0.85) for those 50-59 years, 1.26% (0.93, 1.71) for those 60-69 years, and 2.32% (1.74, 3.08) for those 70 years or above. The overall female to male ratio of the PACG prevalence was 1.51∶1 (95% CI 1.01, 2.28).PACG affects approximately 0.75% adult Asians, increasing double per decade, and 60% of cases being female. The prevalence rates vary greatly by ethnic region.http://europepmc.org/articles/PMC4110010?pdf=render |
| spellingShingle | Jin-Wei Cheng Ying Zong You-Yan Zeng Rui-Li Wei The prevalence of primary angle closure glaucoma in adult Asians: a systematic review and meta-analysis. PLoS ONE |
| title | The prevalence of primary angle closure glaucoma in adult Asians: a systematic review and meta-analysis. |
| title_full | The prevalence of primary angle closure glaucoma in adult Asians: a systematic review and meta-analysis. |
| title_fullStr | The prevalence of primary angle closure glaucoma in adult Asians: a systematic review and meta-analysis. |
| title_full_unstemmed | The prevalence of primary angle closure glaucoma in adult Asians: a systematic review and meta-analysis. |
| title_short | The prevalence of primary angle closure glaucoma in adult Asians: a systematic review and meta-analysis. |
| title_sort | prevalence of primary angle closure glaucoma in adult asians a systematic review and meta analysis |
| url | http://europepmc.org/articles/PMC4110010?pdf=render |
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