Melanogenesis and Melasma Treatment
Melanocytes are highly specialised dendritic cells that transfer melanin to keratinocytes in subcellular lysosome-like organelles called melanosomes, where melanin is synthesised and stored. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair, and eyes of mammals....
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
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| Series: | Cosmetics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-9284/8/3/82 |
| _version_ | 1797519773215490048 |
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| author | Adriana Solange Maddaleno Judit Camargo Montserrat Mitjans Maria Pilar Vinardell |
| author_facet | Adriana Solange Maddaleno Judit Camargo Montserrat Mitjans Maria Pilar Vinardell |
| author_sort | Adriana Solange Maddaleno |
| collection | DOAJ |
| description | Melanocytes are highly specialised dendritic cells that transfer melanin to keratinocytes in subcellular lysosome-like organelles called melanosomes, where melanin is synthesised and stored. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair, and eyes of mammals. The regulation of melanogenesis includes various mechanisms and factors including genetic, environmental, and endocrine factors. Knowledge of the pigmentation process is important not only to understand hyperpigmentation but also to design treatments and therapies to treat them. Whitening cosmetics with anti-melanogenesis activity are very popular. In the present manuscript, we review the mechanisms and the signalling pathways involved in skin pigmentation and we specifically focus on the alteration of melanogenesis that leads to melasma and results in hyperpigmentation. Finally, current therapies and treatments including topical, oral, and phototherapies are discussed and described, with a special emphasis on the cosmetics’ action. |
| first_indexed | 2024-03-10T07:47:32Z |
| format | Article |
| id | doaj.art-8c7cc9d45bd648d5b06ccf5c94869092 |
| institution | Directory Open Access Journal |
| issn | 2079-9284 |
| language | English |
| last_indexed | 2024-03-10T07:47:32Z |
| publishDate | 2021-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cosmetics |
| spelling | doaj.art-8c7cc9d45bd648d5b06ccf5c948690922023-11-22T12:34:11ZengMDPI AGCosmetics2079-92842021-09-01838210.3390/cosmetics8030082Melanogenesis and Melasma TreatmentAdriana Solange Maddaleno0Judit Camargo1Montserrat Mitjans2Maria Pilar Vinardell3Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, 08028 Barcelona, SpainRoka Furadada S. L., Llacuna 162-164, 08018 Barcelona, SpainDepartment of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, 08028 Barcelona, SpainDepartment of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, Universitat de Barcelona, 08028 Barcelona, SpainMelanocytes are highly specialised dendritic cells that transfer melanin to keratinocytes in subcellular lysosome-like organelles called melanosomes, where melanin is synthesised and stored. Melanin is a complex pigment that provides colour and photoprotection to the skin, hair, and eyes of mammals. The regulation of melanogenesis includes various mechanisms and factors including genetic, environmental, and endocrine factors. Knowledge of the pigmentation process is important not only to understand hyperpigmentation but also to design treatments and therapies to treat them. Whitening cosmetics with anti-melanogenesis activity are very popular. In the present manuscript, we review the mechanisms and the signalling pathways involved in skin pigmentation and we specifically focus on the alteration of melanogenesis that leads to melasma and results in hyperpigmentation. Finally, current therapies and treatments including topical, oral, and phototherapies are discussed and described, with a special emphasis on the cosmetics’ action.https://www.mdpi.com/2079-9284/8/3/82melanin synthesispigmentationmelasmaMITF |
| spellingShingle | Adriana Solange Maddaleno Judit Camargo Montserrat Mitjans Maria Pilar Vinardell Melanogenesis and Melasma Treatment Cosmetics melanin synthesis pigmentation melasma MITF |
| title | Melanogenesis and Melasma Treatment |
| title_full | Melanogenesis and Melasma Treatment |
| title_fullStr | Melanogenesis and Melasma Treatment |
| title_full_unstemmed | Melanogenesis and Melasma Treatment |
| title_short | Melanogenesis and Melasma Treatment |
| title_sort | melanogenesis and melasma treatment |
| topic | melanin synthesis pigmentation melasma MITF |
| url | https://www.mdpi.com/2079-9284/8/3/82 |
| work_keys_str_mv | AT adrianasolangemaddaleno melanogenesisandmelasmatreatment AT juditcamargo melanogenesisandmelasmatreatment AT montserratmitjans melanogenesisandmelasmatreatment AT mariapilarvinardell melanogenesisandmelasmatreatment |