Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations
Memory includes the processes of acquisition, consolidation and retrieval. In the study of aversive olfactory memory in Drosophila melanogaster, flies are first exposed to an odor (conditioned stimulus, CS+) that is associated with an electric shock (unconditioned stimulus, US), then to another odor...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-04-01
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| Series: | FEBS Open Bio |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/2211-5463.12203 |
| _version_ | 1828130210538586112 |
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| author | Yutaro Ueoka Makoto Hiroi Takashi Abe Tetsuya Tabata |
| author_facet | Yutaro Ueoka Makoto Hiroi Takashi Abe Tetsuya Tabata |
| author_sort | Yutaro Ueoka |
| collection | DOAJ |
| description | Memory includes the processes of acquisition, consolidation and retrieval. In the study of aversive olfactory memory in Drosophila melanogaster, flies are first exposed to an odor (conditioned stimulus, CS+) that is associated with an electric shock (unconditioned stimulus, US), then to another odor (CS−) without the US, before allowing the flies to choose to avoid one of the two odors. The center for memory formation is the mushroom body which consists of Kenyon cells (KCs), dopaminergic neurons (DANs) and mushroom body output neurons (MBONs). However, the roles of individual neurons are not fully understood. We focused on the role of a single pair of GABAergic neurons (MBON‐γ1pedc) and found that it could inhibit the effects of DANs, resulting in the suppression of aversive memory acquisition during the CS− odor presentation, but not during the CS+ odor presentation. We propose that MBON‐γ1pedc suppresses the DAN‐dependent effect that can convey the aversive US during the CS− odor presentation, and thereby prevents an insignificant stimulus from becoming an aversive US. |
| first_indexed | 2024-04-11T16:29:26Z |
| format | Article |
| id | doaj.art-8c7da25ebea4442b8e7ea1376b586aac |
| institution | Directory Open Access Journal |
| issn | 2211-5463 |
| language | English |
| last_indexed | 2024-04-11T16:29:26Z |
| publishDate | 2017-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | FEBS Open Bio |
| spelling | doaj.art-8c7da25ebea4442b8e7ea1376b586aac2022-12-22T04:14:04ZengWileyFEBS Open Bio2211-54632017-04-017456257610.1002/2211-5463.12203Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associationsYutaro Ueoka0Makoto Hiroi1Takashi Abe2Tetsuya Tabata3Department of Biological Sciences Graduate School of Science The University of Tokyo Bunkyo‐ku JapanInstitute of Molecular and Cellular Biosciences The University of Tokyo Bunkyo‐ku JapanInstitute of Molecular and Cellular Biosciences The University of Tokyo Bunkyo‐ku JapanDepartment of Biological Sciences Graduate School of Science The University of Tokyo Bunkyo‐ku JapanMemory includes the processes of acquisition, consolidation and retrieval. In the study of aversive olfactory memory in Drosophila melanogaster, flies are first exposed to an odor (conditioned stimulus, CS+) that is associated with an electric shock (unconditioned stimulus, US), then to another odor (CS−) without the US, before allowing the flies to choose to avoid one of the two odors. The center for memory formation is the mushroom body which consists of Kenyon cells (KCs), dopaminergic neurons (DANs) and mushroom body output neurons (MBONs). However, the roles of individual neurons are not fully understood. We focused on the role of a single pair of GABAergic neurons (MBON‐γ1pedc) and found that it could inhibit the effects of DANs, resulting in the suppression of aversive memory acquisition during the CS− odor presentation, but not during the CS+ odor presentation. We propose that MBON‐γ1pedc suppresses the DAN‐dependent effect that can convey the aversive US during the CS− odor presentation, and thereby prevents an insignificant stimulus from becoming an aversive US.https://doi.org/10.1002/2211-5463.12203dopaminergicDrosophilaMBONmemory acquisitionmemory suppressionolfactory aversive memory |
| spellingShingle | Yutaro Ueoka Makoto Hiroi Takashi Abe Tetsuya Tabata Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations FEBS Open Bio dopaminergic Drosophila MBON memory acquisition memory suppression olfactory aversive memory |
| title | Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations |
| title_full | Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations |
| title_fullStr | Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations |
| title_full_unstemmed | Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations |
| title_short | Suppression of a single pair of mushroom body output neurons in Drosophila triggers aversive associations |
| title_sort | suppression of a single pair of mushroom body output neurons in drosophila triggers aversive associations |
| topic | dopaminergic Drosophila MBON memory acquisition memory suppression olfactory aversive memory |
| url | https://doi.org/10.1002/2211-5463.12203 |
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