uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements

uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements

Activation of transposable elements (TEs) can cause cellular damage. Cytoplasmic nucleic acid sensing pathways evolved to detect pathogens, but can also serve to cull cells with inappropriate TE activation as TEs can be viral mimetics. Epigenetic silencing of TEs is mediated in part by DNA methylati...

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Bibliographic Details
Main Authors: Elena Magnani, Filippo Macchi, Bhavani P. Madakashira, Chi Zhang, Fatima Alaydaroos, Kirsten C. Sadler
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-03-01
Series:Frontiers in Immunology
Subjects:
uhrf1
dnmt1
transposable element
interferon
TNFa
zebrafish
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.627926/full

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