Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids
The liver plays a central role in the regulation of fatty acid metabolism, which is highly sensitive to transcriptional responses to nutrients and hormones. Transcription factors involved in this process include nuclear hormone receptors. One such receptor, PPARα, which is highly expressed in the li...
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MDPI AG
2016-09-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/17/10/1624 |
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| author | Arnaud Polizzi Edwin Fouché Simon Ducheix Frédéric Lasserre Alice P. Marmugi Laila Mselli-Lakhal Nicolas Loiseau Walter Wahli Hervé Guillou Alexandra Montagner |
| author_facet | Arnaud Polizzi Edwin Fouché Simon Ducheix Frédéric Lasserre Alice P. Marmugi Laila Mselli-Lakhal Nicolas Loiseau Walter Wahli Hervé Guillou Alexandra Montagner |
| author_sort | Arnaud Polizzi |
| collection | DOAJ |
| description | The liver plays a central role in the regulation of fatty acid metabolism, which is highly sensitive to transcriptional responses to nutrients and hormones. Transcription factors involved in this process include nuclear hormone receptors. One such receptor, PPARα, which is highly expressed in the liver and activated by a variety of fatty acids, is a critical regulator of hepatic fatty acid catabolism during fasting. The present study compared the influence of dietary fatty acids and fasting on hepatic PPARα-dependent responses. Pparα−/− male mice and their wild-type controls were fed diets containing different fatty acids for 10 weeks prior to being subjected to fasting or normal feeding. In line with the role of PPARα in sensing dietary fatty acids, changes in chronic dietary fat consumption influenced liver damage during fasting. The changes were particularly marked in mice fed diets lacking essential fatty acids. However, fasting, rather than specific dietary fatty acids, induced acute PPARα activity in the liver. Taken together, the data imply that the potent signalling involved in triggering PPARα activity during fasting does not rely on essential fatty acid-derived ligand. |
| first_indexed | 2024-04-12T04:31:23Z |
| format | Article |
| id | doaj.art-8c7e6836daeb45e7824ba4406c9e8233 |
| institution | Directory Open Access Journal |
| issn | 1422-0067 |
| language | English |
| last_indexed | 2024-04-12T04:31:23Z |
| publishDate | 2016-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8c7e6836daeb45e7824ba4406c9e82332022-12-22T03:47:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672016-09-011710162410.3390/ijms17101624ijms17101624Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty AcidsArnaud Polizzi0Edwin Fouché1Simon Ducheix2Frédéric Lasserre3Alice P. Marmugi4Laila Mselli-Lakhal5Nicolas Loiseau6Walter Wahli7Hervé Guillou8Alexandra Montagner9INRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, FranceINRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, FranceINRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, FranceINRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, FranceINRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, FranceINRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, FranceINRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, FranceINRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, FranceINRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, FranceINRA ToxAlim, 180, Chemin de Tournefeuille, 31027 Toulouse Cedex 3, FranceThe liver plays a central role in the regulation of fatty acid metabolism, which is highly sensitive to transcriptional responses to nutrients and hormones. Transcription factors involved in this process include nuclear hormone receptors. One such receptor, PPARα, which is highly expressed in the liver and activated by a variety of fatty acids, is a critical regulator of hepatic fatty acid catabolism during fasting. The present study compared the influence of dietary fatty acids and fasting on hepatic PPARα-dependent responses. Pparα−/− male mice and their wild-type controls were fed diets containing different fatty acids for 10 weeks prior to being subjected to fasting or normal feeding. In line with the role of PPARα in sensing dietary fatty acids, changes in chronic dietary fat consumption influenced liver damage during fasting. The changes were particularly marked in mice fed diets lacking essential fatty acids. However, fasting, rather than specific dietary fatty acids, induced acute PPARα activity in the liver. Taken together, the data imply that the potent signalling involved in triggering PPARα activity during fasting does not rely on essential fatty acid-derived ligand.http://www.mdpi.com/1422-0067/17/10/1624nuclear receptorsPPARαdietary fatty acidsfastingsteatosispolyunsaturated fatty acids |
| spellingShingle | Arnaud Polizzi Edwin Fouché Simon Ducheix Frédéric Lasserre Alice P. Marmugi Laila Mselli-Lakhal Nicolas Loiseau Walter Wahli Hervé Guillou Alexandra Montagner Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids International Journal of Molecular Sciences nuclear receptors PPARα dietary fatty acids fasting steatosis polyunsaturated fatty acids |
| title | Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids |
| title_full | Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids |
| title_fullStr | Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids |
| title_full_unstemmed | Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids |
| title_short | Hepatic Fasting-Induced PPARα Activity Does Not Depend on Essential Fatty Acids |
| title_sort | hepatic fasting induced pparα activity does not depend on essential fatty acids |
| topic | nuclear receptors PPARα dietary fatty acids fasting steatosis polyunsaturated fatty acids |
| url | http://www.mdpi.com/1422-0067/17/10/1624 |
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