Diagnostic assessment and treatment of cherubism as prevention of ocular complications
This is an initiative study. Cherubism as a form of fibrous dysplasia of jaw bones is a congenital hereditary abnormality of osseous tissue maturation. Although the disease requires mostly maxillofacial surgery and orthodontic care, patients also have to be consulted by an ophthalmologist. The purpo...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Ukrainian Society of Ophthalmologists
2022-08-01
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| Series: | Journal of Ophthalmology |
| Subjects: | |
| Online Access: | https://www.ozhurnal.com/en/archive/2022/4/10-fulltext |
| _version_ | 1797401558624763904 |
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| author | R. S. Nazaryan N. N. Mikhailenko Yu. Yu. Yaroslavska A. V. Bondarenko V. V. Gargin M. V. Lytvynenko O. V. Artiomov D. A. Oliynyk T. V. Tregub |
| author_facet | R. S. Nazaryan N. N. Mikhailenko Yu. Yu. Yaroslavska A. V. Bondarenko V. V. Gargin M. V. Lytvynenko O. V. Artiomov D. A. Oliynyk T. V. Tregub |
| author_sort | R. S. Nazaryan |
| collection | DOAJ |
| description | This is an initiative study. Cherubism as a form of fibrous dysplasia of jaw bones is a congenital hereditary abnormality of osseous tissue maturation. Although the disease requires mostly maxillofacial surgery and orthodontic care, patients also have to be consulted by an ophthalmologist. The purpose of this study was to share our experience in the diagnostic assessment and treatment of cherubism, a rare form of fibrous dysplasia that is commonly misdiagnosed, which results in inadequate treatment and may lead to serious ocular complications. We present our experience of diagnostic assessment and treatment of four patients with cherubism for one to twenty years. The diagnosis of cherubism became evident after histological study of the material excised during surgery, because postoperative histology showed that changes were not cancerous (adamantinoma), but dysplastic. In addition, new foci developed or old foci recurred some time after surgery. Consequently, true jaw tumors must be correctly differentiated from dental cysts and from dysplastic bone lesions. Patients were followed up once every 6 months. Over the period of follow-up, ocular involvement was observed in the woman who had been diagnosed in childhood with congenital mixed astigmatism. Given our observations, one may make a conclusion that cherubism, a rare form of fibrous dysplasia, is a hereditary or familial disorder, and regresses after completion of puberty and puberty-related changes in hormonal milieu. Timely orthodontic care (and, if required, maxillofacial surgery care) will facilitate preventing the progression of the disease and its ophthalmological consequences. Special attention of ophthalmologists should be paid to cherubism patients with maxillary lesions. |
| first_indexed | 2024-03-09T02:11:50Z |
| format | Article |
| id | doaj.art-8c7f57a7639244d2aad1c5285e4bb19a |
| institution | Directory Open Access Journal |
| issn | 2412-8740 |
| language | English |
| last_indexed | 2024-03-09T02:11:50Z |
| publishDate | 2022-08-01 |
| publisher | Ukrainian Society of Ophthalmologists |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj.art-8c7f57a7639244d2aad1c5285e4bb19a2023-12-07T09:39:16ZengUkrainian Society of OphthalmologistsJournal of Ophthalmology2412-87402022-08-014626710.31288/oftalmolzh202246267Diagnostic assessment and treatment of cherubism as prevention of ocular complicationsR. S. Nazaryan0N. N. Mikhailenko1Yu. Yu. Yaroslavska2A. V. Bondarenko3V. V. Gargin4M. V. Lytvynenko5O. V. Artiomov6D. A. Oliynyk7T. V. Tregub8Kharkiv National Medical UniversityKharkiv National Medical UniversityKharkiv National Medical UniversityKharkiv National Medical UniversityKharkiv National Medical UniversityOdesa National Medical UniversitySI "The Filatov Institute of Eye Diseases and Tissue Therapy of the NAMS of Ukraine"Odesa National Medical UniversityOdesa National Medical UniversityThis is an initiative study. Cherubism as a form of fibrous dysplasia of jaw bones is a congenital hereditary abnormality of osseous tissue maturation. Although the disease requires mostly maxillofacial surgery and orthodontic care, patients also have to be consulted by an ophthalmologist. The purpose of this study was to share our experience in the diagnostic assessment and treatment of cherubism, a rare form of fibrous dysplasia that is commonly misdiagnosed, which results in inadequate treatment and may lead to serious ocular complications. We present our experience of diagnostic assessment and treatment of four patients with cherubism for one to twenty years. The diagnosis of cherubism became evident after histological study of the material excised during surgery, because postoperative histology showed that changes were not cancerous (adamantinoma), but dysplastic. In addition, new foci developed or old foci recurred some time after surgery. Consequently, true jaw tumors must be correctly differentiated from dental cysts and from dysplastic bone lesions. Patients were followed up once every 6 months. Over the period of follow-up, ocular involvement was observed in the woman who had been diagnosed in childhood with congenital mixed astigmatism. Given our observations, one may make a conclusion that cherubism, a rare form of fibrous dysplasia, is a hereditary or familial disorder, and regresses after completion of puberty and puberty-related changes in hormonal milieu. Timely orthodontic care (and, if required, maxillofacial surgery care) will facilitate preventing the progression of the disease and its ophthalmological consequences. Special attention of ophthalmologists should be paid to cherubism patients with maxillary lesions.https://www.ozhurnal.com/en/archive/2022/4/10-fulltextfibrous dysplasiacherubismcyst-like jaw lesionsorbit |
| spellingShingle | R. S. Nazaryan N. N. Mikhailenko Yu. Yu. Yaroslavska A. V. Bondarenko V. V. Gargin M. V. Lytvynenko O. V. Artiomov D. A. Oliynyk T. V. Tregub Diagnostic assessment and treatment of cherubism as prevention of ocular complications Journal of Ophthalmology fibrous dysplasia cherubism cyst-like jaw lesions orbit |
| title | Diagnostic assessment and treatment of cherubism as prevention of ocular complications |
| title_full | Diagnostic assessment and treatment of cherubism as prevention of ocular complications |
| title_fullStr | Diagnostic assessment and treatment of cherubism as prevention of ocular complications |
| title_full_unstemmed | Diagnostic assessment and treatment of cherubism as prevention of ocular complications |
| title_short | Diagnostic assessment and treatment of cherubism as prevention of ocular complications |
| title_sort | diagnostic assessment and treatment of cherubism as prevention of ocular complications |
| topic | fibrous dysplasia cherubism cyst-like jaw lesions orbit |
| url | https://www.ozhurnal.com/en/archive/2022/4/10-fulltext |
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