Divergent immune landscapes of primary and syngeneic Kras-driven mouse tumor models

Abstract Immune cells play critical functions in cancer, and mice with intact immune systems are vital to understanding tumor immunology. Both genetically engineered mouse models (GEMMs) and syngeneic cell transplant approaches use immunocompetent mice to define immune-dependent events in tumor deve...

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Hlavní autoři: Wade R. Gutierrez, Amanda Scherer, Gavin R. McGivney, Qierra R. Brockman, Vickie Knepper-Adrian, Emily A. Laverty, Grace A. Roughton, Rebecca D. Dodd
Médium: Článek
Jazyk:English
Vydáno: Nature Portfolio 2021-01-01
Edice:Scientific Reports
On-line přístup:https://doi.org/10.1038/s41598-020-80216-1