Comprehensive Analysis of Differentially Expressed lncRNAs in the Perivascular Adipose Tissue of Patients with Coronary Heart Disease
Background: Coronary heart disease is a highly prevalent inflammatory disease caused by coronary atherosclerosis. Numerous studies have revealed that perivascular adipose tissue is closely associated with atherosclerosis. Here, we conducted a comprehensive analysis of long non-coding RNAs and mRNAs...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-10-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/23/10/10.31083/j.rcm2310341 |
| _version_ | 1828319413606023168 |
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| author | Xianwei Xie Sunying Wang Jingyi Rao Jing Xue Kaiyang Lin Na Lin Ke Li Shilun Wu Wenjia Liang Yansong Guo |
| author_facet | Xianwei Xie Sunying Wang Jingyi Rao Jing Xue Kaiyang Lin Na Lin Ke Li Shilun Wu Wenjia Liang Yansong Guo |
| author_sort | Xianwei Xie |
| collection | DOAJ |
| description | Background: Coronary heart disease is a highly prevalent inflammatory disease caused by coronary atherosclerosis. Numerous studies have revealed that perivascular adipose tissue is closely associated with atherosclerosis. Here, we conducted a comprehensive analysis of long non-coding RNAs and mRNAs differentially expressed in perivascular adipose tissue in patients with coronary heart disease. Methods: We conducted Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the differentially expressed genes. Furthermore, single sample gene set enrichment analysis, immune infiltration analysis, and co-expression analysis of differentially expressed long non-coding RNAs and immune gene sets were performed. Finally, the starBase and miRTarBase databases were used to construct a competing endogenous RNA network. Results: The results show that aortic perivascular adipose tissue has higher inflammation and immune infiltration levels in patients with coronary heart disease. Dysregulated long non-coding RNAs may be related to immunity, inflammation, and hypoxia. Conclusions: The findings of this study provide new insights into atherosclerosis and coronary heart disease. |
| first_indexed | 2024-04-13T17:56:21Z |
| format | Article |
| id | doaj.art-8c8088f19dce4c989fef50cd06240c25 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-04-13T17:56:21Z |
| publishDate | 2022-10-01 |
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| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-8c8088f19dce4c989fef50cd06240c252022-12-22T02:36:29ZengIMR PressReviews in Cardiovascular Medicine1530-65502022-10-01231034110.31083/j.rcm2310341S1530-6550(22)00617-2Comprehensive Analysis of Differentially Expressed lncRNAs in the Perivascular Adipose Tissue of Patients with Coronary Heart DiseaseXianwei Xie0Sunying Wang1Jingyi Rao2Jing Xue3Kaiyang Lin4Na Lin5Ke Li6Shilun Wu7Wenjia Liang8Yansong Guo9Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 350013 Fuzhou, Fujian, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 350013 Fuzhou, Fujian, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 350013 Fuzhou, Fujian, ChinaBeijing Tiantan Hospital, China National Clinical Research Center of Neurological Diseases, Advanced Innovation Center for Human Brain Protection, The Capital Medical University, 100070 Beijing, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 350013 Fuzhou, Fujian, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 350013 Fuzhou, Fujian, ChinaBeijing Tiantan Hospital, China National Clinical Research Center of Neurological Diseases, Advanced Innovation Center for Human Brain Protection, The Capital Medical University, 100070 Beijing, ChinaDepartment of Hepatobiliary Surgery, Beijing Chaoyang Hospital Affiliated to Capital Medical University, 100043 Beijing, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 350013 Fuzhou, Fujian, ChinaDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, 350013 Fuzhou, Fujian, ChinaBackground: Coronary heart disease is a highly prevalent inflammatory disease caused by coronary atherosclerosis. Numerous studies have revealed that perivascular adipose tissue is closely associated with atherosclerosis. Here, we conducted a comprehensive analysis of long non-coding RNAs and mRNAs differentially expressed in perivascular adipose tissue in patients with coronary heart disease. Methods: We conducted Gene Ontology term and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses of the differentially expressed genes. Furthermore, single sample gene set enrichment analysis, immune infiltration analysis, and co-expression analysis of differentially expressed long non-coding RNAs and immune gene sets were performed. Finally, the starBase and miRTarBase databases were used to construct a competing endogenous RNA network. Results: The results show that aortic perivascular adipose tissue has higher inflammation and immune infiltration levels in patients with coronary heart disease. Dysregulated long non-coding RNAs may be related to immunity, inflammation, and hypoxia. Conclusions: The findings of this study provide new insights into atherosclerosis and coronary heart disease.https://www.imrpress.com/journal/RCM/23/10/10.31083/j.rcm2310341coronary heart diseaseatherosclerosisperivascular adipose tissueimmune systemlong non-coding rnacompeting endogenous rna |
| spellingShingle | Xianwei Xie Sunying Wang Jingyi Rao Jing Xue Kaiyang Lin Na Lin Ke Li Shilun Wu Wenjia Liang Yansong Guo Comprehensive Analysis of Differentially Expressed lncRNAs in the Perivascular Adipose Tissue of Patients with Coronary Heart Disease Reviews in Cardiovascular Medicine coronary heart disease atherosclerosis perivascular adipose tissue immune system long non-coding rna competing endogenous rna |
| title | Comprehensive Analysis of Differentially Expressed lncRNAs in the Perivascular Adipose Tissue of Patients with Coronary Heart Disease |
| title_full | Comprehensive Analysis of Differentially Expressed lncRNAs in the Perivascular Adipose Tissue of Patients with Coronary Heart Disease |
| title_fullStr | Comprehensive Analysis of Differentially Expressed lncRNAs in the Perivascular Adipose Tissue of Patients with Coronary Heart Disease |
| title_full_unstemmed | Comprehensive Analysis of Differentially Expressed lncRNAs in the Perivascular Adipose Tissue of Patients with Coronary Heart Disease |
| title_short | Comprehensive Analysis of Differentially Expressed lncRNAs in the Perivascular Adipose Tissue of Patients with Coronary Heart Disease |
| title_sort | comprehensive analysis of differentially expressed lncrnas in the perivascular adipose tissue of patients with coronary heart disease |
| topic | coronary heart disease atherosclerosis perivascular adipose tissue immune system long non-coding rna competing endogenous rna |
| url | https://www.imrpress.com/journal/RCM/23/10/10.31083/j.rcm2310341 |
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