A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity

A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Spontaneous Metastasis, Without Retaining Antibiotic Activity

Here, we describe the chemical synthesis and biological activity of a new Doxycycline derivative, designed specifically to more effectively target cancer stem cells (CSCs). In this analog, a myristic acid (14 carbon) moiety is covalently attached to the free amino group of 9-amino-Doxycycline. First...

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Bibliographic Details
Main Authors: Béla Ózsvári, Luma G. Magalhães, Joe Latimer, Jussi Kangasmetsa, Federica Sotgia, Michael P. Lisanti
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Oncology
Subjects:
cancer stem-like cells (CSCs)
Doxycycline
myristic acid
fatty acylation
cancer cell metastasis
prophylaxis of metastasis
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.01528/full

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