The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria
Imaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The assessment of iodine concentration within a live...
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| Format: | Article |
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MDPI AG
2023-01-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/12/3/879 |
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| author | Alfonso Reginelli Mariateresa Del Canto Alfredo Clemente Eduardo Gragnano Fabrizio Cioce Fabrizio Urraro Erika Martinelli Salvatore Cappabianca |
| author_facet | Alfonso Reginelli Mariateresa Del Canto Alfredo Clemente Eduardo Gragnano Fabrizio Cioce Fabrizio Urraro Erika Martinelli Salvatore Cappabianca |
| author_sort | Alfonso Reginelli |
| collection | DOAJ |
| description | Imaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The assessment of iodine concentration within a liver lesion reflects the biological properties of the tumor and provides additional information to radiologists that is normally invisible to the human eye. The possibility to predict tumor aggressiveness and therapeutic response based on quantitative and reproducible parameters obtainable from DECT images could improve clinical decisions and drive oncologists to choose the best therapy according to metastasis biological features. Moreover, in comparison with standard dimensional criteria, DECT provides further data on the cancer microenvironment, especially for patients treated with antiangiogenic-based drugs, in which tumor shrinkage is a late parameter of response. We investigated the predictive role of DECT in the early assessment of liver metastasis response to treatment in comparison with standard dimensional criteria during antiangiogenetic-based therapy. |
| first_indexed | 2024-03-11T09:39:04Z |
| format | Article |
| id | doaj.art-8c81a7826da549f29063c05281ca7149 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-11T09:39:04Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-8c81a7826da549f29063c05281ca71492023-11-16T17:08:31ZengMDPI AGJournal of Clinical Medicine2077-03832023-01-0112387910.3390/jcm12030879The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 CriteriaAlfonso Reginelli0Mariateresa Del Canto1Alfredo Clemente2Eduardo Gragnano3Fabrizio Cioce4Fabrizio Urraro5Erika Martinelli6Salvatore Cappabianca7Radiology and Radiotherapy Unit, Department of Precision Medicine, University of Campania “L. Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyRadiology and Radiotherapy Unit, Department of Precision Medicine, University of Campania “L. Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyRadiology and Radiotherapy Unit, Department of Precision Medicine, University of Campania “L. Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyRadiology and Radiotherapy Unit, Department of Precision Medicine, University of Campania “L. Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyRadiology and Radiotherapy Unit, Department of Precision Medicine, University of Campania “L. Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyRadiology and Radiotherapy Unit, Department of Precision Medicine, University of Campania “L. Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyMedical Oncology, Department of Precision Medicine, University of Campania “L. Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyRadiology and Radiotherapy Unit, Department of Precision Medicine, University of Campania “L. Vanvitelli”, Piazza Miraglia 2, 80138 Naples, ItalyImaging assessment of liver lesions is fundamental to predict therapeutic response and improve patient survival rates. Dual-Energy Computed Tomography (DECT) is an increasingly used technique in the oncologic field with many emerging applications. The assessment of iodine concentration within a liver lesion reflects the biological properties of the tumor and provides additional information to radiologists that is normally invisible to the human eye. The possibility to predict tumor aggressiveness and therapeutic response based on quantitative and reproducible parameters obtainable from DECT images could improve clinical decisions and drive oncologists to choose the best therapy according to metastasis biological features. Moreover, in comparison with standard dimensional criteria, DECT provides further data on the cancer microenvironment, especially for patients treated with antiangiogenic-based drugs, in which tumor shrinkage is a late parameter of response. We investigated the predictive role of DECT in the early assessment of liver metastasis response to treatment in comparison with standard dimensional criteria during antiangiogenetic-based therapy.https://www.mdpi.com/2077-0383/12/3/879liver metastasiscomputed tomographydual-energyRECIST criteriatargeted therapy |
| spellingShingle | Alfonso Reginelli Mariateresa Del Canto Alfredo Clemente Eduardo Gragnano Fabrizio Cioce Fabrizio Urraro Erika Martinelli Salvatore Cappabianca The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria Journal of Clinical Medicine liver metastasis computed tomography dual-energy RECIST criteria targeted therapy |
| title | The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria |
| title_full | The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria |
| title_fullStr | The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria |
| title_full_unstemmed | The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria |
| title_short | The Role of Dual-Energy CT for the Assessment of Liver Metastasis Response to Treatment: Above the RECIST 1.1 Criteria |
| title_sort | role of dual energy ct for the assessment of liver metastasis response to treatment above the recist 1 1 criteria |
| topic | liver metastasis computed tomography dual-energy RECIST criteria targeted therapy |
| url | https://www.mdpi.com/2077-0383/12/3/879 |
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