Technical Advancements for Studying Immune Regulation of Disseminated Dormant Cancer Cells
Metastases are a major cause of cancer-related death and despite the fact that they have been focus of intense research over the last two decades, effective therapies for patients with distant secondary lesions are still very limited. In addition, in some tumor types metastases can grow years after...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2020-11-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2020.594514/full |
| _version_ | 1819112738316615680 |
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| author | Luigi Ombrato Marco Montagner |
| author_facet | Luigi Ombrato Marco Montagner |
| author_sort | Luigi Ombrato |
| collection | DOAJ |
| description | Metastases are a major cause of cancer-related death and despite the fact that they have been focus of intense research over the last two decades, effective therapies for patients with distant secondary lesions are still very limited. In addition, in some tumor types metastases can grow years after the patients have been declared clinically cured, indicating that disseminated cancer cells (DCCs) persist undetected for years, even decades in a quiescent state. Clinical and experimental data highlight the importance of the immune system in shaping the fitness and behaviour of DCCs. Here, we review mechanisms of survival, quiescence and outgrowth of DCCs with a special focus on immune-regulation and we highlight the latest cutting-edge techniques for modelling the biology of DCCs in vitro and for studying the metastatic niche in vivo. We believe that a wide dissemination of those techniques will boost scientific findings towards new therapies to defeat metastatic relapses in cancer patients. |
| first_indexed | 2024-12-22T04:18:17Z |
| format | Article |
| id | doaj.art-8c82bba1b2534a3c915562be0e7ad78f |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-22T04:18:17Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-8c82bba1b2534a3c915562be0e7ad78f2022-12-21T18:39:21ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-11-011010.3389/fonc.2020.594514594514Technical Advancements for Studying Immune Regulation of Disseminated Dormant Cancer CellsLuigi Ombrato0Marco Montagner1Barts Cancer Institute, Queen Mary University of London, London, United KingdomDepartment of Molecular Medicine, School of Medicine and Surgery, University of Padua, Padua, ItalyMetastases are a major cause of cancer-related death and despite the fact that they have been focus of intense research over the last two decades, effective therapies for patients with distant secondary lesions are still very limited. In addition, in some tumor types metastases can grow years after the patients have been declared clinically cured, indicating that disseminated cancer cells (DCCs) persist undetected for years, even decades in a quiescent state. Clinical and experimental data highlight the importance of the immune system in shaping the fitness and behaviour of DCCs. Here, we review mechanisms of survival, quiescence and outgrowth of DCCs with a special focus on immune-regulation and we highlight the latest cutting-edge techniques for modelling the biology of DCCs in vitro and for studying the metastatic niche in vivo. We believe that a wide dissemination of those techniques will boost scientific findings towards new therapies to defeat metastatic relapses in cancer patients.https://www.frontiersin.org/articles/10.3389/fonc.2020.594514/fulldormancymetastasistumor microenviroment (TME)immune cellslabeling techniques |
| spellingShingle | Luigi Ombrato Marco Montagner Technical Advancements for Studying Immune Regulation of Disseminated Dormant Cancer Cells Frontiers in Oncology dormancy metastasis tumor microenviroment (TME) immune cells labeling techniques |
| title | Technical Advancements for Studying Immune Regulation of Disseminated Dormant Cancer Cells |
| title_full | Technical Advancements for Studying Immune Regulation of Disseminated Dormant Cancer Cells |
| title_fullStr | Technical Advancements for Studying Immune Regulation of Disseminated Dormant Cancer Cells |
| title_full_unstemmed | Technical Advancements for Studying Immune Regulation of Disseminated Dormant Cancer Cells |
| title_short | Technical Advancements for Studying Immune Regulation of Disseminated Dormant Cancer Cells |
| title_sort | technical advancements for studying immune regulation of disseminated dormant cancer cells |
| topic | dormancy metastasis tumor microenviroment (TME) immune cells labeling techniques |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2020.594514/full |
| work_keys_str_mv | AT luigiombrato technicaladvancementsforstudyingimmuneregulationofdisseminateddormantcancercells AT marcomontagner technicaladvancementsforstudyingimmuneregulationofdisseminateddormantcancercells |