Does the serum vitamin D status and its possible effect on serum anti-müllerian hormone levels predict fertility in premenopausal women?
Context: Evidence suggests that serum Vitamin D level influences female reproduction. However, clinical studies have reported conflicting evidence on the effect of serum Vitamin D levels on serum Anti-Müllerian hormone (AMH), with little evidence in African women. Aim: The study aimed to compare the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Human Reproductive Sciences |
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| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=3;spage=244;epage=249;aulast=Lawal |
| _version_ | 1831583805846061056 |
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| author | Oyinkansola Islamiyat Lawal |
| author_facet | Oyinkansola Islamiyat Lawal |
| author_sort | Oyinkansola Islamiyat Lawal |
| collection | DOAJ |
| description | Context: Evidence suggests that serum Vitamin D level influences female reproduction. However, clinical studies have reported conflicting evidence on the effect of serum Vitamin D levels on serum Anti-Müllerian hormone (AMH), with little evidence in African women. Aim: The study aimed to compare the relationship between serum Vitamin D and serum AMH among infertile and fertile women. Settings and Design: This comparative cross-sectional study analyzed data from 170 premenopausal women; 81 infertile, and 89 fertile women attending a Nigerian tertiary hospital between March and June 2019. Materials and Methods: Serum AMH and 25-hydroxyvitamin D (25(OH) Vitamin D) concentrations were analysed using enzyme-linked immunosorbent assay. Statistical Analysis: Statistical analysis was done using SPSS version 25 for windows. Categorical variables were summarized in frequencies and proportions while continuous variables were summarized in means ± standard deviation and median (interquartile range). The association was explored using linear regression. The level of significance was set at 0.05. Results: The prevalence of Vitamin D deficiency (<20 ng/ml) in infertile women and fertile women was 16% and 18%, respectively. There was no difference in serum Vitamin D levels between infertile and fertile women in this study after controlling for age and body mass index (BMI) (P = 0.186). There was no association between serum 25(OH) Vitamin D and serum AMH in infertile (B = 0.002; P = 0.474) and fertile women (B = ‒0.002; P = 0.522) after adjusting for age and BMI. Conclusion: Infertile and fertile women had similar serum Vitamin D levels and there was no relationship between serum Vitamin D and serum AMH in both infertile and fertile women. |
| first_indexed | 2024-12-17T20:48:30Z |
| format | Article |
| id | doaj.art-8c861074f8434883b299c3505d6f1c0f |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-17T20:48:30Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-8c861074f8434883b299c3505d6f1c0f2022-12-21T21:33:05ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662021-01-0114324424910.4103/jhrs.jhrs_234_20Does the serum vitamin D status and its possible effect on serum anti-müllerian hormone levels predict fertility in premenopausal women?Oyinkansola Islamiyat LawalContext: Evidence suggests that serum Vitamin D level influences female reproduction. However, clinical studies have reported conflicting evidence on the effect of serum Vitamin D levels on serum Anti-Müllerian hormone (AMH), with little evidence in African women. Aim: The study aimed to compare the relationship between serum Vitamin D and serum AMH among infertile and fertile women. Settings and Design: This comparative cross-sectional study analyzed data from 170 premenopausal women; 81 infertile, and 89 fertile women attending a Nigerian tertiary hospital between March and June 2019. Materials and Methods: Serum AMH and 25-hydroxyvitamin D (25(OH) Vitamin D) concentrations were analysed using enzyme-linked immunosorbent assay. Statistical Analysis: Statistical analysis was done using SPSS version 25 for windows. Categorical variables were summarized in frequencies and proportions while continuous variables were summarized in means ± standard deviation and median (interquartile range). The association was explored using linear regression. The level of significance was set at 0.05. Results: The prevalence of Vitamin D deficiency (<20 ng/ml) in infertile women and fertile women was 16% and 18%, respectively. There was no difference in serum Vitamin D levels between infertile and fertile women in this study after controlling for age and body mass index (BMI) (P = 0.186). There was no association between serum 25(OH) Vitamin D and serum AMH in infertile (B = 0.002; P = 0.474) and fertile women (B = ‒0.002; P = 0.522) after adjusting for age and BMI. Conclusion: Infertile and fertile women had similar serum Vitamin D levels and there was no relationship between serum Vitamin D and serum AMH in both infertile and fertile women.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=3;spage=244;epage=249;aulast=Lawal25-hydroxyvitamin danti-müllerian hormoneinfertilityovarian reservepremenopausal womenvitamin d |
| spellingShingle | Oyinkansola Islamiyat Lawal Does the serum vitamin D status and its possible effect on serum anti-müllerian hormone levels predict fertility in premenopausal women? Journal of Human Reproductive Sciences 25-hydroxyvitamin d anti-müllerian hormone infertility ovarian reserve premenopausal women vitamin d |
| title | Does the serum vitamin D status and its possible effect on serum anti-müllerian hormone levels predict fertility in premenopausal women? |
| title_full | Does the serum vitamin D status and its possible effect on serum anti-müllerian hormone levels predict fertility in premenopausal women? |
| title_fullStr | Does the serum vitamin D status and its possible effect on serum anti-müllerian hormone levels predict fertility in premenopausal women? |
| title_full_unstemmed | Does the serum vitamin D status and its possible effect on serum anti-müllerian hormone levels predict fertility in premenopausal women? |
| title_short | Does the serum vitamin D status and its possible effect on serum anti-müllerian hormone levels predict fertility in premenopausal women? |
| title_sort | does the serum vitamin d status and its possible effect on serum anti mullerian hormone levels predict fertility in premenopausal women |
| topic | 25-hydroxyvitamin d anti-müllerian hormone infertility ovarian reserve premenopausal women vitamin d |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2021;volume=14;issue=3;spage=244;epage=249;aulast=Lawal |
| work_keys_str_mv | AT oyinkansolaislamiyatlawal doestheserumvitamindstatusanditspossibleeffectonserumantimullerianhormonelevelspredictfertilityinpremenopausalwomen |