Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization
The objective of the present study was to alter the crystal habit of itraconazole (ITZ) by cooling and anti-solvent crystallization and characterize its properties. ITZ was recrystallized in different solvents and the effects of each solvent on morphology of crystals, dissolution behavior and solid...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-06-01
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| Series: | Asian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1818087615000148 |
| _version_ | 1828498523028455424 |
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| author | Pornsak Sriamornsak Kanokporn Burapapadh |
| author_facet | Pornsak Sriamornsak Kanokporn Burapapadh |
| author_sort | Pornsak Sriamornsak |
| collection | DOAJ |
| description | The objective of the present study was to alter the crystal habit of itraconazole (ITZ) by cooling and anti-solvent crystallization and characterize its properties. ITZ was recrystallized in different solvents and the effects of each solvent on morphology of crystals, dissolution behavior and solid state of recrystallized drug particles were investigated. The results revealed that ITZ crystals recrystallized by cooling and anti-solvent crystallization showed the different crystal habits from the untreated ITZ. Using cooling crystallization tended to provide needle-shaped crystals while the crystals obtained from anti-solvent crystallization showed more flaky, plate shape. This indicated the importance of preparation method on nucleation and crystal growth. No change in drug polymorphism was observed, according to determination of thermal property and crystalline state by differential scanning calorimetry and powder X-ray diffractometry, respectively. The recrystallized ITZ showed higher drug dissolution than untreated ITZ and the highest drug dissolution was observed from the samples recrystallized in the presence of PEG 200, which provided the small plate-shaped crystals with tremendously increased in surface area. However, the increasing of drug dissolution is relatively small, therefore, further development may be required. |
| first_indexed | 2024-12-11T13:07:33Z |
| format | Article |
| id | doaj.art-8c86ae25bb7342f3b55f4e235e6b18be |
| institution | Directory Open Access Journal |
| issn | 1818-0876 |
| language | English |
| last_indexed | 2024-12-11T13:07:33Z |
| publishDate | 2015-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Asian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-8c86ae25bb7342f3b55f4e235e6b18be2022-12-22T01:06:16ZengElsevierAsian Journal of Pharmaceutical Sciences1818-08762015-06-0110323023810.1016/j.ajps.2015.01.003Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallizationPornsak Sriamornsak0Kanokporn Burapapadh1Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, ThailandThe objective of the present study was to alter the crystal habit of itraconazole (ITZ) by cooling and anti-solvent crystallization and characterize its properties. ITZ was recrystallized in different solvents and the effects of each solvent on morphology of crystals, dissolution behavior and solid state of recrystallized drug particles were investigated. The results revealed that ITZ crystals recrystallized by cooling and anti-solvent crystallization showed the different crystal habits from the untreated ITZ. Using cooling crystallization tended to provide needle-shaped crystals while the crystals obtained from anti-solvent crystallization showed more flaky, plate shape. This indicated the importance of preparation method on nucleation and crystal growth. No change in drug polymorphism was observed, according to determination of thermal property and crystalline state by differential scanning calorimetry and powder X-ray diffractometry, respectively. The recrystallized ITZ showed higher drug dissolution than untreated ITZ and the highest drug dissolution was observed from the samples recrystallized in the presence of PEG 200, which provided the small plate-shaped crystals with tremendously increased in surface area. However, the increasing of drug dissolution is relatively small, therefore, further development may be required.http://www.sciencedirect.com/science/article/pii/S1818087615000148ItraconazolePoorly water-soluble drugCooling crystallizationAnti-solvent crystallization |
| spellingShingle | Pornsak Sriamornsak Kanokporn Burapapadh Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization Asian Journal of Pharmaceutical Sciences Itraconazole Poorly water-soluble drug Cooling crystallization Anti-solvent crystallization |
| title | Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization |
| title_full | Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization |
| title_fullStr | Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization |
| title_full_unstemmed | Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization |
| title_short | Characterization of recrystallized itraconazole prepared by cooling and anti-solvent crystallization |
| title_sort | characterization of recrystallized itraconazole prepared by cooling and anti solvent crystallization |
| topic | Itraconazole Poorly water-soluble drug Cooling crystallization Anti-solvent crystallization |
| url | http://www.sciencedirect.com/science/article/pii/S1818087615000148 |
| work_keys_str_mv | AT pornsaksriamornsak characterizationofrecrystallizeditraconazolepreparedbycoolingandantisolventcrystallization AT kanokpornburapapadh characterizationofrecrystallizeditraconazolepreparedbycoolingandantisolventcrystallization |