Transmission, Strain Diversity, and Zoonotic Potential of Chronic Wasting Disease
Chronic wasting disease (CWD) is a prion disease affecting several species of captive and free-ranging cervids. In the past few decades, CWD has been spreading uncontrollably, mostly in North America, resulting in a high increase of CWD incidence but also a substantially higher number of geographica...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/14/7/1390 |
| _version_ | 1797443165270048768 |
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| author | Sandra Pritzkow |
| author_facet | Sandra Pritzkow |
| author_sort | Sandra Pritzkow |
| collection | DOAJ |
| description | Chronic wasting disease (CWD) is a prion disease affecting several species of captive and free-ranging cervids. In the past few decades, CWD has been spreading uncontrollably, mostly in North America, resulting in a high increase of CWD incidence but also a substantially higher number of geographical regions affected. The massive increase in CWD poses risks at several levels, including contamination of the environment, transmission to animals cohabiting with cervids, and more importantly, a putative transmission to humans. In this review, I will describe the mechanisms and routes responsible for the efficient transmission of CWD, the strain diversity of natural CWD, its spillover and zoonotic potential and strategies to minimize the CWD threat. |
| first_indexed | 2024-03-09T12:52:06Z |
| format | Article |
| id | doaj.art-8c88de348b6d421993ca672d89a04720 |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-09T12:52:06Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-8c88de348b6d421993ca672d89a047202023-11-30T22:04:27ZengMDPI AGViruses1999-49152022-06-01147139010.3390/v14071390Transmission, Strain Diversity, and Zoonotic Potential of Chronic Wasting DiseaseSandra Pritzkow0Mitchell Center for Alzheimer’s Disease and Related Brain Disorders, Department of Neurology, University of Texas McGovern Medical School, Houston, TX 77030, USAChronic wasting disease (CWD) is a prion disease affecting several species of captive and free-ranging cervids. In the past few decades, CWD has been spreading uncontrollably, mostly in North America, resulting in a high increase of CWD incidence but also a substantially higher number of geographical regions affected. The massive increase in CWD poses risks at several levels, including contamination of the environment, transmission to animals cohabiting with cervids, and more importantly, a putative transmission to humans. In this review, I will describe the mechanisms and routes responsible for the efficient transmission of CWD, the strain diversity of natural CWD, its spillover and zoonotic potential and strategies to minimize the CWD threat.https://www.mdpi.com/1999-4915/14/7/1390prionsprion diseaseschronic wasting diseaseprion strainsPMCAspillover potential |
| spellingShingle | Sandra Pritzkow Transmission, Strain Diversity, and Zoonotic Potential of Chronic Wasting Disease Viruses prions prion diseases chronic wasting disease prion strains PMCA spillover potential |
| title | Transmission, Strain Diversity, and Zoonotic Potential of Chronic Wasting Disease |
| title_full | Transmission, Strain Diversity, and Zoonotic Potential of Chronic Wasting Disease |
| title_fullStr | Transmission, Strain Diversity, and Zoonotic Potential of Chronic Wasting Disease |
| title_full_unstemmed | Transmission, Strain Diversity, and Zoonotic Potential of Chronic Wasting Disease |
| title_short | Transmission, Strain Diversity, and Zoonotic Potential of Chronic Wasting Disease |
| title_sort | transmission strain diversity and zoonotic potential of chronic wasting disease |
| topic | prions prion diseases chronic wasting disease prion strains PMCA spillover potential |
| url | https://www.mdpi.com/1999-4915/14/7/1390 |
| work_keys_str_mv | AT sandrapritzkow transmissionstraindiversityandzoonoticpotentialofchronicwastingdisease |