Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites
Myxobacteria are famous for their ability to produce most intriguing secondary metabolites. Till recently, only terrestrial myxobacteria were in the focus of research. In this review, however, we discuss marine-derived myxobacteria, which are particularly interesting due to their relatively recent d...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Beilstein-Institut
2016-05-01
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| Series: | Beilstein Journal of Organic Chemistry |
| Subjects: | |
| Online Access: | https://doi.org/10.3762/bjoc.12.96 |
| _version_ | 1819275175299907584 |
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| author | Antonio Dávila-Céspedes Peter Hufendiek Max Crüsemann Till F. Schäberle Gabriele M. König |
| author_facet | Antonio Dávila-Céspedes Peter Hufendiek Max Crüsemann Till F. Schäberle Gabriele M. König |
| author_sort | Antonio Dávila-Céspedes |
| collection | DOAJ |
| description | Myxobacteria are famous for their ability to produce most intriguing secondary metabolites. Till recently, only terrestrial myxobacteria were in the focus of research. In this review, however, we discuss marine-derived myxobacteria, which are particularly interesting due to their relatively recent discovery and due to the fact that their very existence was called into question. The to-date-explored members of these halophilic or halotolerant myxobacteria are all grouped into the suborder Nannocystineae. Few of them were chemically investigated revealing around 11 structural types belonging to the polyketide, non-ribosomal peptide, hybrids thereof or terpenoid class of secondary metabolites. A most unusual structural type is represented by salimabromide from Enhygromyxa salina. In silico analyses were carried out on the available genome sequences of four bacterial members of the Nannocystineae, revealing the biosynthetic potential of these bacteria. |
| first_indexed | 2024-12-23T23:20:09Z |
| format | Article |
| id | doaj.art-8c89348cc9dc4062928bcb12023996ba |
| institution | Directory Open Access Journal |
| issn | 1860-5397 |
| language | English |
| last_indexed | 2024-12-23T23:20:09Z |
| publishDate | 2016-05-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj.art-8c89348cc9dc4062928bcb12023996ba2022-12-21T17:26:22ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972016-05-0112196998410.3762/bjoc.12.961860-5397-12-96Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolitesAntonio Dávila-Céspedes0Peter Hufendiek1Max Crüsemann2Till F. Schäberle3Gabriele M. König4Institute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, GermanyInstitute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, GermanyInstitute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, GermanyInstitute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, GermanyInstitute for Pharmaceutical Biology, University of Bonn, Nussallee 6, 53115 Bonn, GermanyMyxobacteria are famous for their ability to produce most intriguing secondary metabolites. Till recently, only terrestrial myxobacteria were in the focus of research. In this review, however, we discuss marine-derived myxobacteria, which are particularly interesting due to their relatively recent discovery and due to the fact that their very existence was called into question. The to-date-explored members of these halophilic or halotolerant myxobacteria are all grouped into the suborder Nannocystineae. Few of them were chemically investigated revealing around 11 structural types belonging to the polyketide, non-ribosomal peptide, hybrids thereof or terpenoid class of secondary metabolites. A most unusual structural type is represented by salimabromide from Enhygromyxa salina. In silico analyses were carried out on the available genome sequences of four bacterial members of the Nannocystineae, revealing the biosynthetic potential of these bacteria.https://doi.org/10.3762/bjoc.12.96Enhygromyxagenome miningmyxobacteriaNannocystineaenatural products |
| spellingShingle | Antonio Dávila-Céspedes Peter Hufendiek Max Crüsemann Till F. Schäberle Gabriele M. König Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites Beilstein Journal of Organic Chemistry Enhygromyxa genome mining myxobacteria Nannocystineae natural products |
| title | Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites |
| title_full | Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites |
| title_fullStr | Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites |
| title_full_unstemmed | Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites |
| title_short | Marine-derived myxobacteria of the suborder Nannocystineae: An underexplored source of structurally intriguing and biologically active metabolites |
| title_sort | marine derived myxobacteria of the suborder nannocystineae an underexplored source of structurally intriguing and biologically active metabolites |
| topic | Enhygromyxa genome mining myxobacteria Nannocystineae natural products |
| url | https://doi.org/10.3762/bjoc.12.96 |
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