A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients
Background: Neutrophil to lymphocyte ratio was initially used as a low cost prognostic marker in a group of solid tumors and subsequently hypothesized to have a role in multiple myeloma. This retrospective analysis aimed to report the prognostic importance of the neutrophil to lymphocyte ratio in mu...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2018-07-01
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| Series: | Middle East Journal of Cancer |
| Subjects: | |
| Online Access: | http://mejc.sums.ac.ir/index.php/mejc/article/view/718 |
| _version_ | 1828267989590343680 |
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| author | Hasan Jalaeikhoo Morteza Sharifzadeh Mohsen Rajaeinejad Manoutchehr Keyhani Mohammad Zokaasadi |
| author_facet | Hasan Jalaeikhoo Morteza Sharifzadeh Mohsen Rajaeinejad Manoutchehr Keyhani Mohammad Zokaasadi |
| author_sort | Hasan Jalaeikhoo |
| collection | DOAJ |
| description | Background: Neutrophil to lymphocyte ratio was initially used as a low cost prognostic marker in a group of solid tumors and subsequently hypothesized to have a role in multiple myeloma. This retrospective analysis aimed to report the prognostic importance of the neutrophil to lymphocyte ratio in multiple myeloma.
Methods: Between November 2003 and February 2016, we included 175 patients from two centers in this study. CBC differentials were primarily checked by a Sysmex analyzer in both centers. In one center, differentials were rechecked by light microscopy. Analysis of survival was performed using a Kaplan-Meier estimate and we assessed the effects of prognostic factors by Cox proportional hazards model.
Results: Patients had a mean age of 63.22±10.89 years. Although mean lymphocyte percent did not differ between the two centers, mean neutrophil percent and mean neutrophil to lymphocyte ratio were higher at the center that manually checked the CBC differentials. After adjustments for age and gender, we noted that the hazard ratio for elevated neutrophil to lymphocyte ratio when stratified for the centers was 1.07 (95% CI: 1.01–1.15, P=0.034).
Conclusion: A precisely checked neutrophil to lymphocyte ratio could act as a potentially inexpensive, accessible prognostic factor for multiple myeloma patients. |
| first_indexed | 2024-04-13T05:13:03Z |
| format | Article |
| id | doaj.art-8c8abc667bb24f548cb17a33515425f9 |
| institution | Directory Open Access Journal |
| issn | 2008-6709 2008-6687 |
| language | English |
| last_indexed | 2024-04-13T05:13:03Z |
| publishDate | 2018-07-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Middle East Journal of Cancer |
| spelling | doaj.art-8c8abc667bb24f548cb17a33515425f92022-12-22T03:00:59ZengShiraz University of Medical SciencesMiddle East Journal of Cancer2008-67092008-66872018-07-0193223227A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma PatientsHasan Jalaeikhoo0Morteza Sharifzadeh1Mohsen Rajaeinejad2Manoutchehr Keyhani3Mohammad Zokaasadi4AJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, IranAJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, IranAJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, IranHematology and Oncology Research Center, Vali Asr Hospital, Tehran University of Medical Sciences, Tehran, IranAJA Cancer Epidemiology Research and Treatment Center (AJA- CERTC), AJA University of Medical Sciences, Tehran, IranBackground: Neutrophil to lymphocyte ratio was initially used as a low cost prognostic marker in a group of solid tumors and subsequently hypothesized to have a role in multiple myeloma. This retrospective analysis aimed to report the prognostic importance of the neutrophil to lymphocyte ratio in multiple myeloma. Methods: Between November 2003 and February 2016, we included 175 patients from two centers in this study. CBC differentials were primarily checked by a Sysmex analyzer in both centers. In one center, differentials were rechecked by light microscopy. Analysis of survival was performed using a Kaplan-Meier estimate and we assessed the effects of prognostic factors by Cox proportional hazards model. Results: Patients had a mean age of 63.22±10.89 years. Although mean lymphocyte percent did not differ between the two centers, mean neutrophil percent and mean neutrophil to lymphocyte ratio were higher at the center that manually checked the CBC differentials. After adjustments for age and gender, we noted that the hazard ratio for elevated neutrophil to lymphocyte ratio when stratified for the centers was 1.07 (95% CI: 1.01–1.15, P=0.034). Conclusion: A precisely checked neutrophil to lymphocyte ratio could act as a potentially inexpensive, accessible prognostic factor for multiple myeloma patients.http://mejc.sums.ac.ir/index.php/mejc/article/view/718Multiple myelomaNeutrophil to lymphocyte ratioSurvival analysisPrognosis |
| spellingShingle | Hasan Jalaeikhoo Morteza Sharifzadeh Mohsen Rajaeinejad Manoutchehr Keyhani Mohammad Zokaasadi A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients Middle East Journal of Cancer Multiple myeloma Neutrophil to lymphocyte ratio Survival analysis Prognosis |
| title | A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients |
| title_full | A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients |
| title_fullStr | A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients |
| title_full_unstemmed | A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients |
| title_short | A Precisely Calculated Neutrophil to Lymphocyte Ratio could Predict Overall Survival in Multiple Myeloma Patients |
| title_sort | precisely calculated neutrophil to lymphocyte ratio could predict overall survival in multiple myeloma patients |
| topic | Multiple myeloma Neutrophil to lymphocyte ratio Survival analysis Prognosis |
| url | http://mejc.sums.ac.ir/index.php/mejc/article/view/718 |
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