Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood[S]

Tissue-specific knockouts of ACAT2 reveal that intestinal depletion is sufficient to prevent diet-induced cholesterol accumulation in the liver and blood[S]

Acyl-CoA:cholesterol acyltransferase 2 (ACAT2) generates cholesterol esters (CE) for packaging into newly synthesized lipoproteins and thus is a major determinant of blood cholesterol levels. ACAT2 is expressed exclusively in the small intestine and liver, but the relative contributions of ACAT2 exp...

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Bibliographic Details
Main Authors: Jun Zhang, Kathryn L. Kelley, Stephanie M. Marshall, Matthew A. Davis, Martha D. Wilson, Janet K. Sawyer, Robert V. Farese, Jr, J.Mark Brown, Lawrence L. Rudel
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Journal of Lipid Research
Subjects:
Acyl-CoA:cholesterol acyltransferase
cholesteryl ester
lipids and lipoproteins
atherosclerosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520317077

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