Computational Analyses for Identification Novel MicroRNAs from Cattle and Sheep
MicroRNAs (miRNA) are a class of noncoding and regulatory RNA molecules about 22 nucleotides in length. MicroRNAs regulate gene expression by an RNA interfering pathway through cleavage or inhibition of the translation of target mRNA. Many miRNAs have been reported for their important roles in devel...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Ferdowsi University of Mashhad
2012-06-01
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| Series: | Journal of Cell and Molecular Research |
| Subjects: | |
| Online Access: | https://jcmr.um.ac.ir/article_26635_d57706de7b0170a0d98f410b69aa7eec.pdf |
| _version_ | 1818976084620738560 |
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| author | Balal Sadeghi Mohammadreza Nassiri Ali Masoudi-Nejad Mojtaba Tahmoorespour Hesam Dehghani Hamed Ahmadi |
| author_facet | Balal Sadeghi Mohammadreza Nassiri Ali Masoudi-Nejad Mojtaba Tahmoorespour Hesam Dehghani Hamed Ahmadi |
| author_sort | Balal Sadeghi |
| collection | DOAJ |
| description | MicroRNAs (miRNA) are a class of noncoding and regulatory RNA molecules about 22 nucleotides in
length. MicroRNAs regulate gene expression by an RNA interfering pathway through cleavage or inhibition of
the translation of target mRNA. Many miRNAs have been reported for their important roles in developmental
processes in various animals, but there is limited information about cattle and sheep miRNAs. The comparative
genomics approach due to their conserved nature is a good source for the miRNAs discovery. Cattle and sheep
are ideal model organisms for biological and comparative genomics studies. In our study, a computational
method based on expressed sequence tag (EST) analysis was used for detection of cattle and sheep miRNAs. In
cattle, 25 miRNA candidates found by homology searching frequently clustered at certain chromosomes and
28 miRNAs in sheep had been detected. Our results show that the cattle and sheep miRNA database can be
providing useful information for investigating biological functions of miRNAs in cattle and sheep.
Furthermore, the bioinformatics approach is a good manner for studying these functions. |
| first_indexed | 2024-12-20T16:06:14Z |
| format | Article |
| id | doaj.art-8c8d59068fba4ff2a395dd3773d5faf5 |
| institution | Directory Open Access Journal |
| issn | 2008-9147 2717-3364 |
| language | English |
| last_indexed | 2024-12-20T16:06:14Z |
| publishDate | 2012-06-01 |
| publisher | Ferdowsi University of Mashhad |
| record_format | Article |
| series | Journal of Cell and Molecular Research |
| spelling | doaj.art-8c8d59068fba4ff2a395dd3773d5faf52022-12-21T19:34:08ZengFerdowsi University of MashhadJournal of Cell and Molecular Research2008-91472717-33642012-06-0142626710.22067/jcmr.v4i2.1619326635Computational Analyses for Identification Novel MicroRNAs from Cattle and SheepBalal SadeghiMohammadreza NassiriAli Masoudi-NejadMojtaba TahmoorespourHesam DehghaniHamed AhmadiMicroRNAs (miRNA) are a class of noncoding and regulatory RNA molecules about 22 nucleotides in length. MicroRNAs regulate gene expression by an RNA interfering pathway through cleavage or inhibition of the translation of target mRNA. Many miRNAs have been reported for their important roles in developmental processes in various animals, but there is limited information about cattle and sheep miRNAs. The comparative genomics approach due to their conserved nature is a good source for the miRNAs discovery. Cattle and sheep are ideal model organisms for biological and comparative genomics studies. In our study, a computational method based on expressed sequence tag (EST) analysis was used for detection of cattle and sheep miRNAs. In cattle, 25 miRNA candidates found by homology searching frequently clustered at certain chromosomes and 28 miRNAs in sheep had been detected. Our results show that the cattle and sheep miRNA database can be providing useful information for investigating biological functions of miRNAs in cattle and sheep. Furthermore, the bioinformatics approach is a good manner for studying these functions.https://jcmr.um.ac.ir/article_26635_d57706de7b0170a0d98f410b69aa7eec.pdfmicrornascomparative genomicshomology searchingsheepcattle |
| spellingShingle | Balal Sadeghi Mohammadreza Nassiri Ali Masoudi-Nejad Mojtaba Tahmoorespour Hesam Dehghani Hamed Ahmadi Computational Analyses for Identification Novel MicroRNAs from Cattle and Sheep Journal of Cell and Molecular Research micrornas comparative genomics homology searching sheep cattle |
| title | Computational Analyses for Identification Novel MicroRNAs from Cattle and Sheep |
| title_full | Computational Analyses for Identification Novel MicroRNAs from Cattle and Sheep |
| title_fullStr | Computational Analyses for Identification Novel MicroRNAs from Cattle and Sheep |
| title_full_unstemmed | Computational Analyses for Identification Novel MicroRNAs from Cattle and Sheep |
| title_short | Computational Analyses for Identification Novel MicroRNAs from Cattle and Sheep |
| title_sort | computational analyses for identification novel micrornas from cattle and sheep |
| topic | micrornas comparative genomics homology searching sheep cattle |
| url | https://jcmr.um.ac.ir/article_26635_d57706de7b0170a0d98f410b69aa7eec.pdf |
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