Associations Between 25-Hydroxyvitamin D and Total and γ' Fibrinogen and Plasma Clot Properties and Gene Interactions in a Group of Healthy Black South African Women
The role of 25-hydroxyvitamin D [25(OH)D] in reducing the risk of cardiovascular disease (CVD) has been recognized, but the mechanisms involved are unclear. Researchers have discovered a link between vitamin D and fibrinogen. Until now, data on the relationship between vitamin D and the γ' spli...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-07-01
|
| Series: | Frontiers in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2022.868542/full |
| _version_ | 1811297201742151680 |
|---|---|
| author | Petro H. Rautenbach Cornelie Nienaber-Rousseau Cornelie Nienaber-Rousseau Zelda de Lange-Loots Zelda de Lange-Loots Iolanthé M. Kruger Marlien Pieters Marlien Pieters |
| author_facet | Petro H. Rautenbach Cornelie Nienaber-Rousseau Cornelie Nienaber-Rousseau Zelda de Lange-Loots Zelda de Lange-Loots Iolanthé M. Kruger Marlien Pieters Marlien Pieters |
| author_sort | Petro H. Rautenbach |
| collection | DOAJ |
| description | The role of 25-hydroxyvitamin D [25(OH)D] in reducing the risk of cardiovascular disease (CVD) has been recognized, but the mechanisms involved are unclear. Researchers have discovered a link between vitamin D and fibrinogen. Until now, data on the relationship between vitamin D and the γ' splice variant of fibrinogen and fibrin clot characteristics remain unexplored. In this study, 25(OH)D, total and γ' fibrinogen, as well as turbidimetrically determined plasma clot properties, were quantified, and fibrinogen and FXIII SNPs were genotyped in 660 Black, apparently healthy South African women. Alarmingly, 16 and 45% of the women presented with deficient and insufficient 25(OH)D, respectively. Total fibrinogen and maximum absorbance (as a measure of clot density) correlated inversely, whereas γ' fibrinogen correlated positively with 25(OH)D. γ' fibrinogen increased whereas maximum absorbance decreased over the deficient, insufficient, and sufficient 25(OH)D categories before and after adjustment for confounders. 25(OH)D modulated the association of the SNPs regarding fibrinogen concentration and clot structure/properties, but did not stand after correction for false discovery rate. Because only weak relationships were detected, the clinical significance of the findings are questionable and remain to be determined. However, we recommend vitamin D fortification and supplementation to reduce the high prevalence of this micronutrient deficiency and possibly to improve fibrinogen and plasma clot structure if the relationships are indeed clinically significant. There is a need for large cohort studies to demonstrate the relationship between vitamin D and cardiovascular and inflammatory risk factors as well as to uncover the molecular mechanisms responsible. |
| first_indexed | 2024-04-13T06:00:40Z |
| format | Article |
| id | doaj.art-8c8e0f99eb6b49c9a3b1608f36ea6f95 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-04-13T06:00:40Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-8c8e0f99eb6b49c9a3b1608f36ea6f952022-12-22T02:59:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2022-07-01910.3389/fcvm.2022.868542868542Associations Between 25-Hydroxyvitamin D and Total and γ' Fibrinogen and Plasma Clot Properties and Gene Interactions in a Group of Healthy Black South African WomenPetro H. Rautenbach0Cornelie Nienaber-Rousseau1Cornelie Nienaber-Rousseau2Zelda de Lange-Loots3Zelda de Lange-Loots4Iolanthé M. Kruger5Marlien Pieters6Marlien Pieters7Centre of Excellence for Nutrition, North-West University, Potchefstroom, South AfricaCentre of Excellence for Nutrition, North-West University, Potchefstroom, South AfricaMedical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South AfricaCentre of Excellence for Nutrition, North-West University, Potchefstroom, South AfricaMedical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South AfricaAfrica Unit for Transdisciplinary Health Research (AUTHeR), North-West University, Potchefstroom, South AfricaCentre of Excellence for Nutrition, North-West University, Potchefstroom, South AfricaMedical Research Council Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South AfricaThe role of 25-hydroxyvitamin D [25(OH)D] in reducing the risk of cardiovascular disease (CVD) has been recognized, but the mechanisms involved are unclear. Researchers have discovered a link between vitamin D and fibrinogen. Until now, data on the relationship between vitamin D and the γ' splice variant of fibrinogen and fibrin clot characteristics remain unexplored. In this study, 25(OH)D, total and γ' fibrinogen, as well as turbidimetrically determined plasma clot properties, were quantified, and fibrinogen and FXIII SNPs were genotyped in 660 Black, apparently healthy South African women. Alarmingly, 16 and 45% of the women presented with deficient and insufficient 25(OH)D, respectively. Total fibrinogen and maximum absorbance (as a measure of clot density) correlated inversely, whereas γ' fibrinogen correlated positively with 25(OH)D. γ' fibrinogen increased whereas maximum absorbance decreased over the deficient, insufficient, and sufficient 25(OH)D categories before and after adjustment for confounders. 25(OH)D modulated the association of the SNPs regarding fibrinogen concentration and clot structure/properties, but did not stand after correction for false discovery rate. Because only weak relationships were detected, the clinical significance of the findings are questionable and remain to be determined. However, we recommend vitamin D fortification and supplementation to reduce the high prevalence of this micronutrient deficiency and possibly to improve fibrinogen and plasma clot structure if the relationships are indeed clinically significant. There is a need for large cohort studies to demonstrate the relationship between vitamin D and cardiovascular and inflammatory risk factors as well as to uncover the molecular mechanisms responsible.https://www.frontiersin.org/articles/10.3389/fcvm.2022.868542/fullcholecalciferolergocalciferolfiber densityfibrinolysislag timelateral aggregation |
| spellingShingle | Petro H. Rautenbach Cornelie Nienaber-Rousseau Cornelie Nienaber-Rousseau Zelda de Lange-Loots Zelda de Lange-Loots Iolanthé M. Kruger Marlien Pieters Marlien Pieters Associations Between 25-Hydroxyvitamin D and Total and γ' Fibrinogen and Plasma Clot Properties and Gene Interactions in a Group of Healthy Black South African Women Frontiers in Cardiovascular Medicine cholecalciferol ergocalciferol fiber density fibrinolysis lag time lateral aggregation |
| title | Associations Between 25-Hydroxyvitamin D and Total and γ' Fibrinogen and Plasma Clot Properties and Gene Interactions in a Group of Healthy Black South African Women |
| title_full | Associations Between 25-Hydroxyvitamin D and Total and γ' Fibrinogen and Plasma Clot Properties and Gene Interactions in a Group of Healthy Black South African Women |
| title_fullStr | Associations Between 25-Hydroxyvitamin D and Total and γ' Fibrinogen and Plasma Clot Properties and Gene Interactions in a Group of Healthy Black South African Women |
| title_full_unstemmed | Associations Between 25-Hydroxyvitamin D and Total and γ' Fibrinogen and Plasma Clot Properties and Gene Interactions in a Group of Healthy Black South African Women |
| title_short | Associations Between 25-Hydroxyvitamin D and Total and γ' Fibrinogen and Plasma Clot Properties and Gene Interactions in a Group of Healthy Black South African Women |
| title_sort | associations between 25 hydroxyvitamin d and total and γ fibrinogen and plasma clot properties and gene interactions in a group of healthy black south african women |
| topic | cholecalciferol ergocalciferol fiber density fibrinolysis lag time lateral aggregation |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2022.868542/full |
| work_keys_str_mv | AT petrohrautenbach associationsbetween25hydroxyvitamindandtotalandgfibrinogenandplasmaclotpropertiesandgeneinteractionsinagroupofhealthyblacksouthafricanwomen AT cornelienienaberrousseau associationsbetween25hydroxyvitamindandtotalandgfibrinogenandplasmaclotpropertiesandgeneinteractionsinagroupofhealthyblacksouthafricanwomen AT cornelienienaberrousseau associationsbetween25hydroxyvitamindandtotalandgfibrinogenandplasmaclotpropertiesandgeneinteractionsinagroupofhealthyblacksouthafricanwomen AT zeldadelangeloots associationsbetween25hydroxyvitamindandtotalandgfibrinogenandplasmaclotpropertiesandgeneinteractionsinagroupofhealthyblacksouthafricanwomen AT zeldadelangeloots associationsbetween25hydroxyvitamindandtotalandgfibrinogenandplasmaclotpropertiesandgeneinteractionsinagroupofhealthyblacksouthafricanwomen AT iolanthemkruger associationsbetween25hydroxyvitamindandtotalandgfibrinogenandplasmaclotpropertiesandgeneinteractionsinagroupofhealthyblacksouthafricanwomen AT marlienpieters associationsbetween25hydroxyvitamindandtotalandgfibrinogenandplasmaclotpropertiesandgeneinteractionsinagroupofhealthyblacksouthafricanwomen AT marlienpieters associationsbetween25hydroxyvitamindandtotalandgfibrinogenandplasmaclotpropertiesandgeneinteractionsinagroupofhealthyblacksouthafricanwomen |