Engineering Polymeric Nanosystems against Oral Diseases
Nanotechnology and nanoparticles (NPs) are at the forefront of modern research, particularly in the case of healthcare therapeutic applications. Polymeric NPs, specifically, hold high promise for these purposes, including towards oral diseases. Careful optimisation of the production of polymeric NPs...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/26/8/2229 |
| _version_ | 1797537935866724352 |
|---|---|
| author | Valeria Mercadante Edoardo Scarpa Valeria De Matteis Loris Rizzello Alessandro Poma |
| author_facet | Valeria Mercadante Edoardo Scarpa Valeria De Matteis Loris Rizzello Alessandro Poma |
| author_sort | Valeria Mercadante |
| collection | DOAJ |
| description | Nanotechnology and nanoparticles (NPs) are at the forefront of modern research, particularly in the case of healthcare therapeutic applications. Polymeric NPs, specifically, hold high promise for these purposes, including towards oral diseases. Careful optimisation of the production of polymeric NPs, however, is required to generate a product which can be easily translated from a laboratory environment to the actual clinical usage. Indeed, considerations such as biocompatibility, biodistribution, and biodegradability are paramount. Moreover, a pre-clinical assessment in adequate in vitro, ex vivo or in vivo model is also required. Last but not least, considerations for the scale-up are also important, together with an appropriate clinical testing pathway. This review aims to eviscerate the above topics, sourcing at examples from the recent literature to put in context the current most burdening oral diseases and the most promising polymeric NPs which would be suitable against them. |
| first_indexed | 2024-03-10T12:23:20Z |
| format | Article |
| id | doaj.art-8c8f8cdab19a4380934394c42a3b91e7 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:23:20Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8c8f8cdab19a4380934394c42a3b91e72023-11-21T15:17:06ZengMDPI AGMolecules1420-30492021-04-01268222910.3390/molecules26082229Engineering Polymeric Nanosystems against Oral DiseasesValeria Mercadante0Edoardo Scarpa1Valeria De Matteis2Loris Rizzello3Alessandro Poma4Division of Oral Medicine, UCL Eastman Dental Institute, Bloomsbury Campus, Rockefeller Building, 21 University Street, London WC1E 6DE, UKDepartment of Pharmaceutical Sciences (DISFARM), National Institute of Molecular Genetics (INGM), Via G. Balzaretti 9, 20133 Milan, ItalyDepartment of Mathematics and Physics “Ennio De Giorgi”, Via Monteroni, c/o Campus Ecotekne, 73100 Lecce, ItalyDepartment of Pharmaceutical Sciences (DISFARM), National Institute of Molecular Genetics (INGM), Via G. Balzaretti 9, 20133 Milan, ItalyDivision of Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, Royal Free Hospital, UCL Medical School, Rowland Hill Street, London NW3 2PF, UKNanotechnology and nanoparticles (NPs) are at the forefront of modern research, particularly in the case of healthcare therapeutic applications. Polymeric NPs, specifically, hold high promise for these purposes, including towards oral diseases. Careful optimisation of the production of polymeric NPs, however, is required to generate a product which can be easily translated from a laboratory environment to the actual clinical usage. Indeed, considerations such as biocompatibility, biodistribution, and biodegradability are paramount. Moreover, a pre-clinical assessment in adequate in vitro, ex vivo or in vivo model is also required. Last but not least, considerations for the scale-up are also important, together with an appropriate clinical testing pathway. This review aims to eviscerate the above topics, sourcing at examples from the recent literature to put in context the current most burdening oral diseases and the most promising polymeric NPs which would be suitable against them.https://www.mdpi.com/1420-3049/26/8/2229nanotechnologypolymeric nanoparticlesoral diseasesoral medicinecariesrestorative dentistry |
| spellingShingle | Valeria Mercadante Edoardo Scarpa Valeria De Matteis Loris Rizzello Alessandro Poma Engineering Polymeric Nanosystems against Oral Diseases Molecules nanotechnology polymeric nanoparticles oral diseases oral medicine caries restorative dentistry |
| title | Engineering Polymeric Nanosystems against Oral Diseases |
| title_full | Engineering Polymeric Nanosystems against Oral Diseases |
| title_fullStr | Engineering Polymeric Nanosystems against Oral Diseases |
| title_full_unstemmed | Engineering Polymeric Nanosystems against Oral Diseases |
| title_short | Engineering Polymeric Nanosystems against Oral Diseases |
| title_sort | engineering polymeric nanosystems against oral diseases |
| topic | nanotechnology polymeric nanoparticles oral diseases oral medicine caries restorative dentistry |
| url | https://www.mdpi.com/1420-3049/26/8/2229 |
| work_keys_str_mv | AT valeriamercadante engineeringpolymericnanosystemsagainstoraldiseases AT edoardoscarpa engineeringpolymericnanosystemsagainstoraldiseases AT valeriadematteis engineeringpolymericnanosystemsagainstoraldiseases AT lorisrizzello engineeringpolymericnanosystemsagainstoraldiseases AT alessandropoma engineeringpolymericnanosystemsagainstoraldiseases |