Lactiplantibacillus plantarum L67 reduces diet-induced obesity by stimulating gene programming for adipose lipolysis and energy expenditure
Obesity and its associated metabolic diseases, including diabetes and fatty liver diseases, represent a significant global health concern. While substantial evidence highlights the role of probiotic bacteria in alleviating diet-induced obesity, the effect of probiotics on lipolysis in relation to di...
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| Formatua: | Artikulua |
| Hizkuntza: | English |
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Elsevier
2024-02-01
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| Saila: | Journal of Functional Foods |
| Gaiak: | |
| Sarrera elektronikoa: | http://www.sciencedirect.com/science/article/pii/S1756464624000306 |
| _version_ | 1827351348130086912 |
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| author | Eunjeong Hong Garam Yang Sejong Oh Eungseok Kim |
| author_facet | Eunjeong Hong Garam Yang Sejong Oh Eungseok Kim |
| author_sort | Eunjeong Hong |
| collection | DOAJ |
| description | Obesity and its associated metabolic diseases, including diabetes and fatty liver diseases, represent a significant global health concern. While substantial evidence highlights the role of probiotic bacteria in alleviating diet-induced obesity, the effect of probiotics on lipolysis in relation to diet-induced obesity remains unexplored. This study demonstrated that administration of Lactiplantibacillus plantarum L67 (L67) ameliorated diet-induced obesity, lipid accumulation in adipose and liver tissues, and insulin resistance and improved cold tolerance in high-fat diet (HFD)-fed mice by regulating the expression of lipolysis- and energy dissipation-related genes. Notably, L67 administration increased PPARγ deacetylation by increasing Sirt1 expression, which, in turn, regulated the expression of genes related to lipolysis (ATGL and G0S2) and thermogenesis (UCP1 and PGC-1α), facilitating lipolysis, and enhancing mitochondrial levels and oxygen consumption rates in adipocytes. Overall, these findings suggest that L67 protects against diet-induced obesity and associated metabolic abnormalities by stimulating lipolysis and energy expenditure. |
| first_indexed | 2024-03-08T02:02:13Z |
| format | Article |
| id | doaj.art-8c8f9a349d3047c8b51c4845fdea58a4 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-03-08T02:02:13Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8c8f9a349d3047c8b51c4845fdea58a42024-02-14T05:14:32ZengElsevierJournal of Functional Foods1756-46462024-02-01113106028Lactiplantibacillus plantarum L67 reduces diet-induced obesity by stimulating gene programming for adipose lipolysis and energy expenditureEunjeong Hong0Garam Yang1Sejong Oh2Eungseok Kim3Department of Biological Sciences, College of Natural Sciences, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of KoreaDepartment of Biological Sciences, College of Natural Sciences, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of KoreaDivision of Animal Science, College of Agriculture & Life Sciences, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea; Corresponding authors.Department of Biological Sciences, College of Natural Sciences, Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 61186, Republic of Korea; Corresponding authors.Obesity and its associated metabolic diseases, including diabetes and fatty liver diseases, represent a significant global health concern. While substantial evidence highlights the role of probiotic bacteria in alleviating diet-induced obesity, the effect of probiotics on lipolysis in relation to diet-induced obesity remains unexplored. This study demonstrated that administration of Lactiplantibacillus plantarum L67 (L67) ameliorated diet-induced obesity, lipid accumulation in adipose and liver tissues, and insulin resistance and improved cold tolerance in high-fat diet (HFD)-fed mice by regulating the expression of lipolysis- and energy dissipation-related genes. Notably, L67 administration increased PPARγ deacetylation by increasing Sirt1 expression, which, in turn, regulated the expression of genes related to lipolysis (ATGL and G0S2) and thermogenesis (UCP1 and PGC-1α), facilitating lipolysis, and enhancing mitochondrial levels and oxygen consumption rates in adipocytes. Overall, these findings suggest that L67 protects against diet-induced obesity and associated metabolic abnormalities by stimulating lipolysis and energy expenditure.http://www.sciencedirect.com/science/article/pii/S1756464624000306Lactiplantibacillus plantarum L67ObesityAdipose lipolysisEnergy homeostasisInsulin resistanceInsulin sensitivity |
| spellingShingle | Eunjeong Hong Garam Yang Sejong Oh Eungseok Kim Lactiplantibacillus plantarum L67 reduces diet-induced obesity by stimulating gene programming for adipose lipolysis and energy expenditure Journal of Functional Foods Lactiplantibacillus plantarum L67 Obesity Adipose lipolysis Energy homeostasis Insulin resistance Insulin sensitivity |
| title | Lactiplantibacillus plantarum L67 reduces diet-induced obesity by stimulating gene programming for adipose lipolysis and energy expenditure |
| title_full | Lactiplantibacillus plantarum L67 reduces diet-induced obesity by stimulating gene programming for adipose lipolysis and energy expenditure |
| title_fullStr | Lactiplantibacillus plantarum L67 reduces diet-induced obesity by stimulating gene programming for adipose lipolysis and energy expenditure |
| title_full_unstemmed | Lactiplantibacillus plantarum L67 reduces diet-induced obesity by stimulating gene programming for adipose lipolysis and energy expenditure |
| title_short | Lactiplantibacillus plantarum L67 reduces diet-induced obesity by stimulating gene programming for adipose lipolysis and energy expenditure |
| title_sort | lactiplantibacillus plantarum l67 reduces diet induced obesity by stimulating gene programming for adipose lipolysis and energy expenditure |
| topic | Lactiplantibacillus plantarum L67 Obesity Adipose lipolysis Energy homeostasis Insulin resistance Insulin sensitivity |
| url | http://www.sciencedirect.com/science/article/pii/S1756464624000306 |
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