Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort study: The Isfahan Cohort Study
<div><div><div><p><strong>BACKGROUND:</strong> Numerous studies have been conducted on the predictive effects of high-sensitivity C-reactive protein (hs-CRP) on cardiovascular events. Few studies have been conducted to investigate the effects of adiponectin for th...
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| Format: | Article |
| Language: | English |
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Vesnu Publications
2016-05-01
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| Series: | ARYA Atherosclerosis |
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| Online Access: | http://arya.mui.ac.ir/index.php/arya/article/view/1128 |
| _version_ | 1818560367925657600 |
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| author | Davoud Kazemi-Saleh Pooya Koosha Masoumeh Sadeghi Nizal Sarrafzadegan Reza Karbasi-Afshar Mansoureh Boshtam Shahram Oveis-Gharan |
| author_facet | Davoud Kazemi-Saleh Pooya Koosha Masoumeh Sadeghi Nizal Sarrafzadegan Reza Karbasi-Afshar Mansoureh Boshtam Shahram Oveis-Gharan |
| author_sort | Davoud Kazemi-Saleh |
| collection | DOAJ |
| description | <div><div><div><p><strong>BACKGROUND:</strong> Numerous studies have been conducted on the predictive effects of high-sensitivity C-reactive protein (hs-CRP) on cardiovascular events. Few studies have been conducted to investigate the effects of adiponectin for the prediction of the incident of cardiovascular events in the Middle East area. This study compared the predictive effect of hs-CRP and adiponectin on healthy volunteers for the prediction of cerebrovascular disease (CVD).</p> <p><strong>METHODS:</strong> This nested case-control in original Isfahan Cohort Study (ICS) was conducted from 2001 to 2011. Participants were selected from ICS. The case group included participants with CVD while the control group included participants without CVD. The level of hs-CRP and adiponectin was measured in the blood samples collected in the year 2007. Thereafter, the statistical analyses were performed to determine the predictive value of hs-CRP and adiponectin in CVD prediction.</p> <p><strong>RESULTS:</strong><strong> </strong>The results showed that before the elimination of diabetes effect; there was a significant difference between the two groups, in terms of the mean of adiponectin (P = 0.019) and no significant difference was observed in hs-CRP levels (P = 0.673). However, after eliminating the factor of diabetes, there was no significant difference between the case and control groups in adiponectin and hs-CRP levels (P = 0.184, P = 0.946). The results showed that the odds ratio (OR) of the adiponectin level was 0.879 [95% confidence interval (CI): 0.719-1.075, P = 0.210] while the OR of hs-CRP was 1.045 (95% CI: 0.922-1.185, P = 0.491). Furthermore, it was shown that after adjustment for age, sex, and diabetes; the OR of adiponectine was 0.875 (95% CI: 0.701-1.091, P = 0.235) and that of hs-CRP was 1.068 (95% <br /> CI: 0.935-1.219, P = 0.333).</p> <p><strong>CONCLUSION:</strong> The results show that adiponectin and hs-CRP cannot be predictors for cardiovascular events in a healthy population. Risk factors such as diabetes limit the use of adiponectin as a CVD predictor.</p></div><p> </p></div></div> |
| first_indexed | 2024-12-14T00:37:36Z |
| format | Article |
| id | doaj.art-8c8fb55f7539483999e597b49587fa98 |
| institution | Directory Open Access Journal |
| issn | 1735-3955 2251-6638 |
| language | English |
| last_indexed | 2024-12-14T00:37:36Z |
| publishDate | 2016-05-01 |
| publisher | Vesnu Publications |
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| series | ARYA Atherosclerosis |
| spelling | doaj.art-8c8fb55f7539483999e597b49587fa982022-12-21T23:24:33ZengVesnu PublicationsARYA Atherosclerosis1735-39552251-66382016-05-01123132137590Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort study: The Isfahan Cohort StudyDavoud Kazemi-Saleh0Pooya Koosha1Masoumeh Sadeghi2Nizal Sarrafzadegan3Reza Karbasi-Afshar4Mansoureh Boshtam5Shahram Oveis-Gharan6Professor, Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranResident, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranProfessor, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranProfessor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, IranResearch Assistant, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan AND Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran<div><div><div><p><strong>BACKGROUND:</strong> Numerous studies have been conducted on the predictive effects of high-sensitivity C-reactive protein (hs-CRP) on cardiovascular events. Few studies have been conducted to investigate the effects of adiponectin for the prediction of the incident of cardiovascular events in the Middle East area. This study compared the predictive effect of hs-CRP and adiponectin on healthy volunteers for the prediction of cerebrovascular disease (CVD).</p> <p><strong>METHODS:</strong> This nested case-control in original Isfahan Cohort Study (ICS) was conducted from 2001 to 2011. Participants were selected from ICS. The case group included participants with CVD while the control group included participants without CVD. The level of hs-CRP and adiponectin was measured in the blood samples collected in the year 2007. Thereafter, the statistical analyses were performed to determine the predictive value of hs-CRP and adiponectin in CVD prediction.</p> <p><strong>RESULTS:</strong><strong> </strong>The results showed that before the elimination of diabetes effect; there was a significant difference between the two groups, in terms of the mean of adiponectin (P = 0.019) and no significant difference was observed in hs-CRP levels (P = 0.673). However, after eliminating the factor of diabetes, there was no significant difference between the case and control groups in adiponectin and hs-CRP levels (P = 0.184, P = 0.946). The results showed that the odds ratio (OR) of the adiponectin level was 0.879 [95% confidence interval (CI): 0.719-1.075, P = 0.210] while the OR of hs-CRP was 1.045 (95% CI: 0.922-1.185, P = 0.491). Furthermore, it was shown that after adjustment for age, sex, and diabetes; the OR of adiponectine was 0.875 (95% CI: 0.701-1.091, P = 0.235) and that of hs-CRP was 1.068 (95% <br /> CI: 0.935-1.219, P = 0.333).</p> <p><strong>CONCLUSION:</strong> The results show that adiponectin and hs-CRP cannot be predictors for cardiovascular events in a healthy population. Risk factors such as diabetes limit the use of adiponectin as a CVD predictor.</p></div><p> </p></div></div>http://arya.mui.ac.ir/index.php/arya/article/view/1128AdiponectinHigh-Sensitivity C-Reactive ProteinCardiovascular Disease |
| spellingShingle | Davoud Kazemi-Saleh Pooya Koosha Masoumeh Sadeghi Nizal Sarrafzadegan Reza Karbasi-Afshar Mansoureh Boshtam Shahram Oveis-Gharan Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort study: The Isfahan Cohort Study ARYA Atherosclerosis Adiponectin High-Sensitivity C-Reactive Protein Cardiovascular Disease |
| title | Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort study: The Isfahan Cohort Study |
| title_full | Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort study: The Isfahan Cohort Study |
| title_fullStr | Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort study: The Isfahan Cohort Study |
| title_full_unstemmed | Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort study: The Isfahan Cohort Study |
| title_short | Predictive role of adiponectin and high-sensitivity C-reactive protein for prediction of cardiovascular event in an Iranian cohort study: The Isfahan Cohort Study |
| title_sort | predictive role of adiponectin and high sensitivity c reactive protein for prediction of cardiovascular event in an iranian cohort study the isfahan cohort study |
| topic | Adiponectin High-Sensitivity C-Reactive Protein Cardiovascular Disease |
| url | http://arya.mui.ac.ir/index.php/arya/article/view/1128 |
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