ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Studys⃞
The genetic variability of apolipoprotein E (apoE) influences plasma lipoprotein levels, and allele frequencies differ between African Americans and Caucasians. As African Americans have higher lipoprotein [a] (Lp[a]) levels than Caucasians, we investigated the effects of the apoE gene on allele-spe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2007-03-01
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| Series: | Journal of Lipid Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520432444 |
| _version_ | 1818601195660378112 |
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| author | Erdembileg Anuurad Guijing Lu Jill Rubin Thomas A. Pearson Lars Berglund |
| author_facet | Erdembileg Anuurad Guijing Lu Jill Rubin Thomas A. Pearson Lars Berglund |
| author_sort | Erdembileg Anuurad |
| collection | DOAJ |
| description | The genetic variability of apolipoprotein E (apoE) influences plasma lipoprotein levels, and allele frequencies differ between African Americans and Caucasians. As African Americans have higher lipoprotein [a] (Lp[a]) levels than Caucasians, we investigated the effects of the apoE gene on allele-specific apolipoprotein [a] (apo[a]) levels across ethnicity. We determined apo[a] sizes, allele-specific apo[a] levels (i.e., levels associated with alleles defined by size), and the apoE gene polymorphism in 231 African Americans and 336 Caucasians. African Americans, but not Caucasians, with the apo E2 genotype had lower levels of Lp[a] compared with those with the apo E4 genotype (9.6 vs. 11.2 nmol/l; P = 0.034, expressed as square root levels). Distribution of apo[a] alleles across apoE genotypes were similar between African Americans and Caucasians. Among African Americans with large apo[a], the allele-specific apo[a] level was significantly lower among ε2 carriers compared with ε3 or ε4 carriers (5.4 vs. 6.6 and 7.4 nmol/l, respectively; P < 0.005, expressed as square root levels). In contrast, there was no significant difference in allele-specific apo[a] levels across apoE genotypes among Caucasians. For large apo[a] sizes, apoE genotype contributed to the observed African American-Caucasian differences in allele-specific apo[a] levels. |
| first_indexed | 2024-12-16T12:47:32Z |
| format | Article |
| id | doaj.art-8c95325c46354f7fbc93f4dd11ccbc38 |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T12:47:32Z |
| publishDate | 2007-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-8c95325c46354f7fbc93f4dd11ccbc382022-12-21T22:31:15ZengElsevierJournal of Lipid Research0022-22752007-03-01483693698ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Studys⃞Erdembileg Anuurad0Guijing Lu1Jill Rubin2Thomas A. Pearson3Lars Berglund4Department of Medicine, University of California, Davis, CADepartment of Medicine, University of California, Davis, CADepartment of Medicine, Columbia University, New York, NYDepartment of Family and Community Medicine, University of Rochester, Rochester, NYDepartment of Medicine, University of California, Davis, CA; Department of Veterans Affairs Northern California Health Care System, Sacramento, CAThe genetic variability of apolipoprotein E (apoE) influences plasma lipoprotein levels, and allele frequencies differ between African Americans and Caucasians. As African Americans have higher lipoprotein [a] (Lp[a]) levels than Caucasians, we investigated the effects of the apoE gene on allele-specific apolipoprotein [a] (apo[a]) levels across ethnicity. We determined apo[a] sizes, allele-specific apo[a] levels (i.e., levels associated with alleles defined by size), and the apoE gene polymorphism in 231 African Americans and 336 Caucasians. African Americans, but not Caucasians, with the apo E2 genotype had lower levels of Lp[a] compared with those with the apo E4 genotype (9.6 vs. 11.2 nmol/l; P = 0.034, expressed as square root levels). Distribution of apo[a] alleles across apoE genotypes were similar between African Americans and Caucasians. Among African Americans with large apo[a], the allele-specific apo[a] level was significantly lower among ε2 carriers compared with ε3 or ε4 carriers (5.4 vs. 6.6 and 7.4 nmol/l, respectively; P < 0.005, expressed as square root levels). In contrast, there was no significant difference in allele-specific apo[a] levels across apoE genotypes among Caucasians. For large apo[a] sizes, apoE genotype contributed to the observed African American-Caucasian differences in allele-specific apo[a] levels.http://www.sciencedirect.com/science/article/pii/S0022227520432444lipoprotein [a]polymorphismsapolipoprotein Egeneticsethnicityapolipoprotein [a] |
| spellingShingle | Erdembileg Anuurad Guijing Lu Jill Rubin Thomas A. Pearson Lars Berglund ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Studys⃞ Journal of Lipid Research lipoprotein [a] polymorphisms apolipoprotein E genetics ethnicity apolipoprotein [a] |
| title | ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Studys⃞ |
| title_full | ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Studys⃞ |
| title_fullStr | ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Studys⃞ |
| title_full_unstemmed | ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Studys⃞ |
| title_short | ApoE genotype affects allele-specific apo[a] levels for large apo[a] sizes in African Americans: the Harlem-Basset Studys⃞ |
| title_sort | apoe genotype affects allele specific apo a levels for large apo a sizes in african americans the harlem basset studys⃞ |
| topic | lipoprotein [a] polymorphisms apolipoprotein E genetics ethnicity apolipoprotein [a] |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520432444 |
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